A4VUG7 (PYRB_STRSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SSU05_0790

Organism

Streptococcus suis (strain 05ZYH33) [Complete proteome] [HAMAP]

Taxonomic identifier

391295 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301629

Sequences

	Sequence		Length	Mass (Da)
	A4VUG7 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 0821ED8B22DEB420	FASTA	307	34,594
	10 20 30 40 50 60 MTITNGKVSL KHLVTMETLS NEEVLGLIQR GIAFKRGEKV ELDRKYYASN LFFEDSTRTH 70 80 90 100 110 120 KSFEMAELRL DMGMIDFDAR TSSVNKGETL CDTILTMSAL GVDICVIRHS EVDYYKQLID 130 140 150 160 170 180 SPTIQTSIVN GGDGSGQHPS QSLLDLMTIY EEFGTFDGLK IAIAGDITHS RVAKSNMQIL 190 200 210 220 230 240 KRLGAEIFFA GPEEWYAEEF DVYGQHLNID DIVETVDVLM LLRVQHERHD GDGGFSKETY 250 260 270 280 290 300 NRLHGLTEER YKRLKDTAIV MHPAPVNRDV EIDDSLVEAP KSRIVRQMQN GVFVRMAILE AIVNGKA

References

[1]

"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates." Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J. PLoS ONE 2:E315-E315(2007) [PubMed: 17375201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 05ZYH33.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000407 Genomic DNA. Translation: ABP89756.1.
RefSeq	YP_001198156.1. NC_009442.1.
3D structure databases
ProteinModelPortal	A4VUG7.
ModBase	Search...
Protein-protein interaction databases
STRING	A4VUG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000053246; EBSTRP00000049433; EBSTRG00000053236.
GeneID	5099585.
GenomeReviews	Gene locus SSU05_0790 in contig CP000407_GR.
KEGG	ssu:SSU05_0790.
PATRIC	19773341. VBIStrSui128929_0769.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000027081.
HOGENOM	HBG579429.
OMA	DLYTIRQ.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SSUI391295:SSU05_0790-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRSY

Accession

Primary (citable) accession number: A4VUG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 29, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program