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A4VUB1 (THIM_STRSY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:SSU05_0734
OrganismStreptococcus suis (strain 05ZYH33) [Complete proteome] [HAMAP]
Taxonomic identifier391295 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336572

Sites

Binding site381Substrate; via amide nitrogen By similarity
Binding site1141ATP By similarity
Binding site1591ATP By similarity
Binding site1861Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A4VUB1 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: B4C95F25A937E506

FASTA26128,149
        10         20         30         40         50         60 
MYLEKLRSQN PLTICITNDV VKNFTANGLL ALGASPAMSE YPEDLEDLLP YTKGLLINTG 

        70         80         90        100        110        120 
TLTNETWELY KSALDIAEKY GVPTVLDPVA AGAGAYRKKV TLDLLHHHTI SLVRGNAGEI 

       130        140        150        160        170        180 
AALIGESIET KGVDSAQIDN VGELALRANQ QLGIPVVITG KKDAVAVNHQ VRILENGSEL 

       190        200        210        220        230        240 
MPLVTGTGCL LGAVLAAFIH LADEDSLLDC LEEVLSAYSI AGEMAEQKTS LPGTFQIEFI 

       250        260 
NSLYAIQSEE VEENKKVIHY E 

« Hide

References

[1]"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. expand/collapse author list , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 05ZYH33.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000407 Genomic DNA. Translation: ABP89700.1.
RefSeqYP_001198100.1. NC_009442.1.

3D structure databases

ProteinModelPortalA4VUB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391295.SSU05_0734.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP89700; ABP89700; SSU05_0734.
GeneID5098868.
KEGGssu:SSU05_0734.
PATRIC19773225. VBIStrSui128929_0715.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycSSUI391295:GHI8-794-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_STRSY
AccessionPrimary (citable) accession number: A4VUB1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 29, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways