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A4VU67

- FTHS_STRSY

UniProt

A4VU67 - FTHS_STRSY

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus suis (strain 05ZYH33)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-750-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SSU05_0690
OrganismiStreptococcus suis (strain 05ZYH33)
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000243: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300548Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391295.SSU05_0690.

Structurei

3D structure databases

ProteinModelPortaliA4VU67.
SMRiA4VU67. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4VU67 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIDIAQS ITLKPITEIV EKVGISFDDI ELYGKYKAKL SFDKINAVKD
60 70 80 90 100
NAPGKLILVT AINPTPAGEG KSTITIGLAD ALSKIGKKTM IALREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHIHQ
160 170 180 190 200
GNVIGIDQRR IIWKRVVDLN DRALRKVTVG LGGPLNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DINDLKERLA NIVIGYRFDC SPVYVRDLAV EGALTLILKD
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKVPNLPK APDAVVIVAT LRALKMHGGV AKTELSAENV
360 370 380 390 400
EAVKAGFSNL KRHVENIRKY GIPAVVAINE FVSDTAAEIA VLKELCAAIG
410 420 430 440 450
VPVELASVWA NGADGGVELA ETVVATIDNQ AASYQRLYKS EDSLEEKVTK
460 470 480 490 500
IVTQIYGGTG VVFEKKARNQ LTEFAKNGWD KLPVCMAKTQ YSFSDDQFAL
510 520 530 540 550
GAPTDFDITV REFVPKLGAG FIVALTGDVM TMPGLPKAPV ALNMDVAADG

TAIGLF
Length:556
Mass (Da):59,108
Last modified:May 29, 2007 - v1
Checksum:i6CC2ED05FD864616
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000407 Genomic DNA. Translation: ABP89656.1.
RefSeqiYP_001198056.1. NC_009442.1.

Genome annotation databases

EnsemblBacteriaiABP89656; ABP89656; SSU05_0690.
GeneIDi5100253.
KEGGissu:SSU05_0690.
PATRICi19773138. VBIStrSui128929_0673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000407 Genomic DNA. Translation: ABP89656.1 .
RefSeqi YP_001198056.1. NC_009442.1.

3D structure databases

ProteinModelPortali A4VU67.
SMRi A4VU67. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391295.SSU05_0690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP89656 ; ABP89656 ; SSU05_0690 .
GeneIDi 5100253.
KEGGi ssu:SSU05_0690.
PATRICi 19773138. VBIStrSui128929_0673.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSUI391295:GHI8-750-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates."
    Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y.
    , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J.
    PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 05ZYH33.

Entry informationi

Entry nameiFTHS_STRSY
AccessioniPrimary (citable) accession number: A4VU67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3