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Protein
Submitted name:

tRNA and rRNA cytosine-C5-methylase

Gene

SSU05_0426

Organism
Streptococcus suis (strain 05ZYH33)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei277S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei305S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei324S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei377NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-462-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
tRNA and rRNA cytosine-C5-methylaseImported
Gene namesi
Ordered Locus Names:SSU05_0426Imported
OrganismiStreptococcus suis (strain 05ZYH33)Imported
Taxonomic identifieri391295 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000243 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi391295.SSU05_0426.

Structurei

3D structure databases

ProteinModelPortaliA4VTF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 436SAM_MT_RSMB_NOPInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.
OrthoDBiPOG091H02E2.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VTF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVINKHETAR SLALSVLEQV FDQGAYSNIA LNKALESSRL SAQDKGLATE
60 70 80 90 100
LVYGTVSRKI TLEWYLAHFI EDREKLDTWV YYLLMLSLYQ LVYLDKLPTH
110 120 130 140 150
AVVNEAVNIA KRKPGTDKFV NAILRKLSQD SLPKPADIKR KNKRLSVQYS
160 170 180 190 200
VPVWLVQTLI AEYGDERAEK IFQSLHDRNK ASVRVTDGQQ VERLAEELGA
210 220 230 240 250
QHSQLSPVGL VKPHGHFAGT DYFKEGLITI QDETSQLVAP TLDIQGDEII
260 270 280 290 300
LDACAAPGGK TCHMASYLTD GKVYALDLYD HKLNLIEENA RRLGLADKIE
310 320 330 340 350
TKGLDASRVH EEFGPDTFDK ILVDAPCSGI GLIRRKPDIR YNKASMDFDS
360 370 380 390 400
LKTIQLQILD SVCQSLKIGG IITYSTCTII AKENQEVIQE FLQNHPNFEQ
410 420 430
VTLEHPQTDI MVDGCLLITP EQYKTDGFFI GQLRRKS
Length:437
Mass (Da):49,148
Last modified:May 29, 2007 - v1
Checksum:i1D3CA6661E6C3C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP89393.1.

Genome annotation databases

EnsemblBacteriaiABP89393; ABP89393; SSU05_0426.
KEGGissu:SSU05_0426.
PATRICi19772565. VBIStrSui128929_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000407 Genomic DNA. Translation: ABP89393.1.

3D structure databases

ProteinModelPortaliA4VTF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391295.SSU05_0426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP89393; ABP89393; SSU05_0426.
KEGGissu:SSU05_0426.
PATRICi19772565. VBIStrSui128929_0402.

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.
OrthoDBiPOG091H02E2.

Enzyme and pathway databases

BioCyciSSUI391295:GHI8-462-MONOMER.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4VTF4_STRSY
AccessioniPrimary (citable) accession number: A4VTF4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: February 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.