A4VTE8 (LUXS_STRSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-ribosylhomocysteine lyase
EC=4.4.1.21

Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS

Gene names

Name:	luxS
Ordered Locus Names:	SSU05_0420

Organism

Streptococcus suis (strain 05ZYH33) [Complete proteome] [HAMAP]

Taxonomic identifier

391295 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus suis

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP-Rule MF_00091
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP-Rule MF_00091
Cofactor	Binds 1 iron ion per subunit By similarity. HAMAP-Rule MF_00091
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00091
Sequence similarities	Belongs to the LuxS family.
Sequence caution	The sequence ABP89387.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Autoinducer synthesis Quorum sensing
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC quorum sensing Inferred from electronic annotation. Source: HAMAP
Molecular_function	S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	S-ribosylhomocysteine lyase HAMAP-Rule MF_00091		PRO_0000298049
Sites
	Metal binding	57	1	Iron By similarity
	Metal binding	61	1	Iron By similarity
	Metal binding	127	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4VTE8 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 5BC4A2C81DB4B846	FASTA	160	17,991
	10 20 30 40 50 60 MKKEVTVESF ELDHTIVKAP YIRLISEEVG PKGDIITNFD IRLIQPNENA MDTAGLHTIE 70 80 90 100 110 120 HLLAKLIRQR IDGLIDCSPF GCRTGFHMIM WGKQDSEKIA QVIKSSLEEI AEGITWEDVP 130 140 150 160 GTTIESCGNY KDHSLHSAKE WAKLILSQGI STDAFERKPI

References

[1]

"A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates." Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X., Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J., Dong Y. , Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F., Yang R., Wang J., Yu J. PLoS ONE 2:E315-E315(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 05ZYH33.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000407 Genomic DNA. Translation: ABP89387.1. Different initiation.
RefSeq	YP_001197787.1. NC_009442.1.
3D structure databases
ProteinModelPortal	A4VTE8.
ModBase	Search...
Protein-protein interaction databases
STRING	391295.SSU05_0420.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP89387; ABP89387; SSU05_0420.
GeneID	5099929.
KEGG	ssu:SSU05_0420.
PATRIC	19772553. VBIStrSui128929_0396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1854.
HOGENOM	HOG000040372.
KO	K07173.
ProtClustDB	PRK02260.
Enzyme and pathway databases
BioCyc	SSUI391295:GHI8-481-MONOMER.
Family and domain databases
Gene3D	3.30.1360.80. 1 hit.
HAMAP	MF_00091. LuxS.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LUXS_STRSY

Accession

Primary (citable) accession number: A4VTE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	May 29, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program