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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PST_4062
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000233 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000455951 – 958Glycine dehydrogenase (decarboxylating)Add BLAST958

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei707N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA4VRT4

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi379731.PST_4062

Structurei

3D structure databases

ProteinModelPortaliA4VRT4
SMRiA4VRT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A4VRT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYMPSLSQL QQTDAFLRRH LGPDQGEQQA MLDALGLASR EQLIEQTVPP
60 70 80 90 100
AIRLQGELNL PPALDEQAAL AKLKGYAEQN QLWTSLIGMG YHGTITPPVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NYQQMIIDLT GLDLANASLL
160 170 180 190 200
DEATAAAEAM TLARRMAKSK SNRFFVDENC HPQTLSVVQT RAEAFGFELV
210 220 230 240 250
VGTLDDLAGH EVFGALLQYP DTHGEIRDLR PAIEQLHAQQ ALACVAADLL
260 270 280 290 300
SLLLLTPPGE LGADVVLGST QRFGVPMGYG GPHAAYFASR DEFKRGMPGR
310 320 330 340 350
IIGVSKDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV
360 370 380 390 400
YHGPQGLKRI AQRVHRLTAI LAAGLEQKGI VRLNRHFFDT LTLEVGGAQT
410 420 430 440 450
AIIESAEAAQ INLRILGRGR LGVSLDETCD ERTVEQLLAI FLGADHGLDV
460 470 480 490 500
AALDAGELAA GIPAGLQRDS GYLEHPVFNS HHSETEMLRY LKQLENKDLA
510 520 530 540 550
LNQAMIPLGS CTMKLNATSE MIPITWAEFA NLHPFVPRGQ AQGYRLMIEE
560 570 580 590 600
LEAWLCAITG FDAISMQPNS GAQGEYAGLV AIRKYHESRG EGQRDICLIP
610 620 630 640 650
SSAHGTNPAS AQMVSMRVVI VECDKGGNVD LEDLKRKAAE AGDRLSCLMI
660 670 680 690 700
TYPSTHGVYE ENVREICAAI HAQGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGVKAHLA PFVANHPVVE LEGPQPGNGA
760 770 780 790 800
VSAAPWGSAS ILPISWMYIA MMGPQLRDAT EVAILGANYL ANRLGGAFPV
810 820 830 840 850
LYSGRNGRVA HECILDLRPL KAASGISEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMIEPTES ESKAELDRFV EAMLSIRAEI AKVQDGEWPA DNNPLVRAPH
910 920 930 940 950
TLADVIGEWD RPYSIAEAVT PSAHARAHKY WPAVNRVDNV YGDRNLFCAC

VPVDAYRD
Length:958
Mass (Da):103,895
Last modified:May 29, 2007 - v1
Checksum:i18A0427530F27288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA Translation: ABP81685.1
RefSeqiWP_011915065.1, NC_009434.1

Genome annotation databases

EnsemblBacteriaiABP81685; ABP81685; PST_4062
KEGGipsa:PST_4062

Similar proteinsi

Entry informationi

Entry nameiGCSP_PSEU5
AccessioniPrimary (citable) accession number: A4VRT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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