Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSTU379731:GJER-4057-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PST_4062
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000233 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi379731.PST_4062.

Structurei

3D structure databases

ProteinModelPortaliA4VRT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VRT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYMPSLSQL QQTDAFLRRH LGPDQGEQQA MLDALGLASR EQLIEQTVPP
60 70 80 90 100
AIRLQGELNL PPALDEQAAL AKLKGYAEQN QLWTSLIGMG YHGTITPPVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NYQQMIIDLT GLDLANASLL
160 170 180 190 200
DEATAAAEAM TLARRMAKSK SNRFFVDENC HPQTLSVVQT RAEAFGFELV
210 220 230 240 250
VGTLDDLAGH EVFGALLQYP DTHGEIRDLR PAIEQLHAQQ ALACVAADLL
260 270 280 290 300
SLLLLTPPGE LGADVVLGST QRFGVPMGYG GPHAAYFASR DEFKRGMPGR
310 320 330 340 350
IIGVSKDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV
360 370 380 390 400
YHGPQGLKRI AQRVHRLTAI LAAGLEQKGI VRLNRHFFDT LTLEVGGAQT
410 420 430 440 450
AIIESAEAAQ INLRILGRGR LGVSLDETCD ERTVEQLLAI FLGADHGLDV
460 470 480 490 500
AALDAGELAA GIPAGLQRDS GYLEHPVFNS HHSETEMLRY LKQLENKDLA
510 520 530 540 550
LNQAMIPLGS CTMKLNATSE MIPITWAEFA NLHPFVPRGQ AQGYRLMIEE
560 570 580 590 600
LEAWLCAITG FDAISMQPNS GAQGEYAGLV AIRKYHESRG EGQRDICLIP
610 620 630 640 650
SSAHGTNPAS AQMVSMRVVI VECDKGGNVD LEDLKRKAAE AGDRLSCLMI
660 670 680 690 700
TYPSTHGVYE ENVREICAAI HAQGGQVYMD GANLNAQVGL ARPADIGADV
710 720 730 740 750
SHMNLHKTFC IPHGGGGPGM GPIGVKAHLA PFVANHPVVE LEGPQPGNGA
760 770 780 790 800
VSAAPWGSAS ILPISWMYIA MMGPQLRDAT EVAILGANYL ANRLGGAFPV
810 820 830 840 850
LYSGRNGRVA HECILDLRPL KAASGISEED VAKRLMDYGF HAPTMSFPVP
860 870 880 890 900
GTLMIEPTES ESKAELDRFV EAMLSIRAEI AKVQDGEWPA DNNPLVRAPH
910 920 930 940 950
TLADVIGEWD RPYSIAEAVT PSAHARAHKY WPAVNRVDNV YGDRNLFCAC

VPVDAYRD
Length:958
Mass (Da):103,895
Last modified:May 29, 2007 - v1
Checksum:i18A0427530F27288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP81685.1.
RefSeqiWP_011915065.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP81685; ABP81685; PST_4062.
KEGGipsa:PST_4062.
PATRICi19968634. VBIPseStu31643_4046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP81685.1.
RefSeqiWP_011915065.1. NC_009434.1.

3D structure databases

ProteinModelPortaliA4VRT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi379731.PST_4062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP81685; ABP81685; PST_4062.
KEGGipsa:PST_4062.
PATRICi19968634. VBIPseStu31643_4046.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPSTU379731:GJER-4057-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
    Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
    , Elmerich C., Lin M., Jin Q.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1501.

Entry informationi

Entry nameiGCSP_PSEU5
AccessioniPrimary (citable) accession number: A4VRT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.