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A4VRT4

- GCSP_PSEU5

UniProt

A4VRT4 - GCSP_PSEU5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (29 May 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPSTU379731:GJER-4057-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PST_4062
    OrganismiPseudomonas stutzeri (strain A1501)
    Taxonomic identifieri379731 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000233: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000045595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei707 – 7071N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi379731.PST_4062.

    Structurei

    3D structure databases

    ProteinModelPortaliA4VRT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4VRT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYMPSLSQL QQTDAFLRRH LGPDQGEQQA MLDALGLASR EQLIEQTVPP    50
    AIRLQGELNL PPALDEQAAL AKLKGYAEQN QLWTSLIGMG YHGTITPPVI 100
    LRNVLENPGW YTAYTPYQPE IAQGRLEALL NYQQMIIDLT GLDLANASLL 150
    DEATAAAEAM TLARRMAKSK SNRFFVDENC HPQTLSVVQT RAEAFGFELV 200
    VGTLDDLAGH EVFGALLQYP DTHGEIRDLR PAIEQLHAQQ ALACVAADLL 250
    SLLLLTPPGE LGADVVLGST QRFGVPMGYG GPHAAYFASR DEFKRGMPGR 300
    IIGVSKDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV 350
    YHGPQGLKRI AQRVHRLTAI LAAGLEQKGI VRLNRHFFDT LTLEVGGAQT 400
    AIIESAEAAQ INLRILGRGR LGVSLDETCD ERTVEQLLAI FLGADHGLDV 450
    AALDAGELAA GIPAGLQRDS GYLEHPVFNS HHSETEMLRY LKQLENKDLA 500
    LNQAMIPLGS CTMKLNATSE MIPITWAEFA NLHPFVPRGQ AQGYRLMIEE 550
    LEAWLCAITG FDAISMQPNS GAQGEYAGLV AIRKYHESRG EGQRDICLIP 600
    SSAHGTNPAS AQMVSMRVVI VECDKGGNVD LEDLKRKAAE AGDRLSCLMI 650
    TYPSTHGVYE ENVREICAAI HAQGGQVYMD GANLNAQVGL ARPADIGADV 700
    SHMNLHKTFC IPHGGGGPGM GPIGVKAHLA PFVANHPVVE LEGPQPGNGA 750
    VSAAPWGSAS ILPISWMYIA MMGPQLRDAT EVAILGANYL ANRLGGAFPV 800
    LYSGRNGRVA HECILDLRPL KAASGISEED VAKRLMDYGF HAPTMSFPVP 850
    GTLMIEPTES ESKAELDRFV EAMLSIRAEI AKVQDGEWPA DNNPLVRAPH 900
    TLADVIGEWD RPYSIAEAVT PSAHARAHKY WPAVNRVDNV YGDRNLFCAC 950
    VPVDAYRD 958
    Length:958
    Mass (Da):103,895
    Last modified:May 29, 2007 - v1
    Checksum:i18A0427530F27288
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000304 Genomic DNA. Translation: ABP81685.1.
    RefSeqiWP_011915065.1. NC_009434.1.
    YP_001174527.1. NC_009434.1.

    Genome annotation databases

    EnsemblBacteriaiABP81685; ABP81685; PST_4062.
    GeneIDi5097021.
    KEGGipsa:PST_4062.
    PATRICi19968634. VBIPseStu31643_4046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000304 Genomic DNA. Translation: ABP81685.1 .
    RefSeqi WP_011915065.1. NC_009434.1.
    YP_001174527.1. NC_009434.1.

    3D structure databases

    ProteinModelPortali A4VRT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 379731.PST_4062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP81685 ; ABP81685 ; PST_4062 .
    GeneIDi 5097021.
    KEGGi psa:PST_4062.
    PATRICi 19968634. VBIPseStu31643_4046.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PSTU379731:GJER-4057-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
      Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
      , Elmerich C., Lin M., Jin Q.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A1501.

    Entry informationi

    Entry nameiGCSP_PSEU5
    AccessioniPrimary (citable) accession number: A4VRT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3