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A4VRT4

- GCSP_PSEU5

UniProt

A4VRT4 - GCSP_PSEU5

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PST_4062
Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPSTU379731:GJER-4057-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PST_4062
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000233: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei707 – 7071N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi379731.PST_4062.

Structurei

3D structure databases

ProteinModelPortaliA4VRT4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VRT4-1 [UniParc]FASTAAdd to Basket

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MPYMPSLSQL QQTDAFLRRH LGPDQGEQQA MLDALGLASR EQLIEQTVPP    50
AIRLQGELNL PPALDEQAAL AKLKGYAEQN QLWTSLIGMG YHGTITPPVI 100
LRNVLENPGW YTAYTPYQPE IAQGRLEALL NYQQMIIDLT GLDLANASLL 150
DEATAAAEAM TLARRMAKSK SNRFFVDENC HPQTLSVVQT RAEAFGFELV 200
VGTLDDLAGH EVFGALLQYP DTHGEIRDLR PAIEQLHAQQ ALACVAADLL 250
SLLLLTPPGE LGADVVLGST QRFGVPMGYG GPHAAYFASR DEFKRGMPGR 300
IIGVSKDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV 350
YHGPQGLKRI AQRVHRLTAI LAAGLEQKGI VRLNRHFFDT LTLEVGGAQT 400
AIIESAEAAQ INLRILGRGR LGVSLDETCD ERTVEQLLAI FLGADHGLDV 450
AALDAGELAA GIPAGLQRDS GYLEHPVFNS HHSETEMLRY LKQLENKDLA 500
LNQAMIPLGS CTMKLNATSE MIPITWAEFA NLHPFVPRGQ AQGYRLMIEE 550
LEAWLCAITG FDAISMQPNS GAQGEYAGLV AIRKYHESRG EGQRDICLIP 600
SSAHGTNPAS AQMVSMRVVI VECDKGGNVD LEDLKRKAAE AGDRLSCLMI 650
TYPSTHGVYE ENVREICAAI HAQGGQVYMD GANLNAQVGL ARPADIGADV 700
SHMNLHKTFC IPHGGGGPGM GPIGVKAHLA PFVANHPVVE LEGPQPGNGA 750
VSAAPWGSAS ILPISWMYIA MMGPQLRDAT EVAILGANYL ANRLGGAFPV 800
LYSGRNGRVA HECILDLRPL KAASGISEED VAKRLMDYGF HAPTMSFPVP 850
GTLMIEPTES ESKAELDRFV EAMLSIRAEI AKVQDGEWPA DNNPLVRAPH 900
TLADVIGEWD RPYSIAEAVT PSAHARAHKY WPAVNRVDNV YGDRNLFCAC 950
VPVDAYRD 958
Length:958
Mass (Da):103,895
Last modified:May 29, 2007 - v1
Checksum:i18A0427530F27288
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000304 Genomic DNA. Translation: ABP81685.1.
RefSeqiWP_011915065.1. NC_009434.1.
YP_001174527.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP81685; ABP81685; PST_4062.
GeneIDi5097021.
KEGGipsa:PST_4062.
PATRICi19968634. VBIPseStu31643_4046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000304 Genomic DNA. Translation: ABP81685.1 .
RefSeqi WP_011915065.1. NC_009434.1.
YP_001174527.1. NC_009434.1.

3D structure databases

ProteinModelPortali A4VRT4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 379731.PST_4062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP81685 ; ABP81685 ; PST_4062 .
GeneIDi 5097021.
KEGGi psa:PST_4062.
PATRICi 19968634. VBIPseStu31643_4046.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PSTU379731:GJER-4057-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
    Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
    , Elmerich C., Lin M., Jin Q.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1501.

Entry informationi

Entry nameiGCSP_PSEU5
AccessioniPrimary (citable) accession number: A4VRT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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