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A4VRT4 (GCSP_PSEU5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PST_4062
OrganismPseudomonas stutzeri (strain A1501) [Complete proteome] [HAMAP]
Taxonomic identifier379731 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045595

Amino acid modifications

Modified residue7071N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4VRT4 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 18A0427530F27288

FASTA958103,895
        10         20         30         40         50         60 
MPYMPSLSQL QQTDAFLRRH LGPDQGEQQA MLDALGLASR EQLIEQTVPP AIRLQGELNL 

        70         80         90        100        110        120 
PPALDEQAAL AKLKGYAEQN QLWTSLIGMG YHGTITPPVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEALL NYQQMIIDLT GLDLANASLL DEATAAAEAM TLARRMAKSK SNRFFVDENC 

       190        200        210        220        230        240 
HPQTLSVVQT RAEAFGFELV VGTLDDLAGH EVFGALLQYP DTHGEIRDLR PAIEQLHAQQ 

       250        260        270        280        290        300 
ALACVAADLL SLLLLTPPGE LGADVVLGST QRFGVPMGYG GPHAAYFASR DEFKRGMPGR 

       310        320        330        340        350        360 
IIGVSKDARG NTALRMALQT REQHIRREKA NSNICTAQVL LANIAGFYAV YHGPQGLKRI 

       370        380        390        400        410        420 
AQRVHRLTAI LAAGLEQKGI VRLNRHFFDT LTLEVGGAQT AIIESAEAAQ INLRILGRGR 

       430        440        450        460        470        480 
LGVSLDETCD ERTVEQLLAI FLGADHGLDV AALDAGELAA GIPAGLQRDS GYLEHPVFNS 

       490        500        510        520        530        540 
HHSETEMLRY LKQLENKDLA LNQAMIPLGS CTMKLNATSE MIPITWAEFA NLHPFVPRGQ 

       550        560        570        580        590        600 
AQGYRLMIEE LEAWLCAITG FDAISMQPNS GAQGEYAGLV AIRKYHESRG EGQRDICLIP 

       610        620        630        640        650        660 
SSAHGTNPAS AQMVSMRVVI VECDKGGNVD LEDLKRKAAE AGDRLSCLMI TYPSTHGVYE 

       670        680        690        700        710        720 
ENVREICAAI HAQGGQVYMD GANLNAQVGL ARPADIGADV SHMNLHKTFC IPHGGGGPGM 

       730        740        750        760        770        780 
GPIGVKAHLA PFVANHPVVE LEGPQPGNGA VSAAPWGSAS ILPISWMYIA MMGPQLRDAT 

       790        800        810        820        830        840 
EVAILGANYL ANRLGGAFPV LYSGRNGRVA HECILDLRPL KAASGISEED VAKRLMDYGF 

       850        860        870        880        890        900 
HAPTMSFPVP GTLMIEPTES ESKAELDRFV EAMLSIRAEI AKVQDGEWPA DNNPLVRAPH 

       910        920        930        940        950 
TLADVIGEWD RPYSIAEAVT PSAHARAHKY WPAVNRVDNV YGDRNLFCAC VPVDAYRD 

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References

[1]"Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y. expand/collapse author list , Elmerich C., Lin M., Jin Q.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A1501.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000304 Genomic DNA. Translation: ABP81685.1.
RefSeqYP_001174527.1. NC_009434.1.

3D structure databases

ProteinModelPortalA4VRT4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING379731.PST_4062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP81685; ABP81685; PST_4062.
GeneID5097021.
KEGGpsa:PST_4062.
PATRIC19968634. VBIPseStu31643_4046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPSTU379731:GJER-4057-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PSEU5
AccessionPrimary (citable) accession number: A4VRT4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families