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A4VQZ0

- SYL_PSEU5

UniProt

A4VQZ0 - SYL_PSEU5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei630 – 6301ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPSTU379731:GJER-3763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PST_3768
    OrganismiPseudomonas stutzeri (strain A1501)
    Taxonomic identifieri379731 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000233: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 868868Leucine--tRNA ligasePRO_0000334796Add
    BLAST

    Proteomic databases

    PRIDEiA4VQZ0.

    Interactioni

    Protein-protein interaction databases

    STRINGi379731.PST_3768.

    Structurei

    3D structure databases

    ProteinModelPortaliA4VQZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi627 – 6315"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4VQZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHEQYQPREI EAAAQSHWDS QKSFEVSEQP GKDTFYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VIARYQRMQG KNVLQPMGWD AFGMPAENAA MKNQVAPAKW 100
    TYENIAYMKA QLKSLGLAID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY 150
    RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITAYAD 200
    ELLESLDELD GWPEQVKTMQ RNWIGKSRGM EISFPYDVAS IGNEGVMKVF 250
    TTRPDTLMGA TYVAVAAEHP LATLAAQHNP ELQAFIDECK RGGVAEADIA 300
    TQEKKGLATS LRVQHPLTGE LLPVWVANYV LMNYGEGAVM AVPAHDERDF 350
    EFASKYGLPI KPVVRTSAGD ETPAPWQDAY GEHGQLINSG IYDGLDFEGA 400
    FDAIEVALQK KGLGQARTQF RLRDWGISRQ RYWGCPIPII HCDSCGDVPV 450
    PEDQLPVVLP EDVVPDGAGS PLARMPEFYE CTCPKCGAPA KRETDTMDTF 500
    VESSWYFARY ASPNYDKGMV DPQAANHWLP VDQYIGGIEH AILHLLYARF 550
    FHKLMRDEGL VSSNEPFKNL LTQGMVVAET YYRTLENGGK DWFNPADVEV 600
    ERDAKAKVIG ARLKTDGLPV EIGGTEKMSK SKNNGVDPQA MIDAYGADTC 650
    RLFMMFASPP DMSLEWSDSG VEGASRFLRR VWRLAHAHVS AGLPGALDVA 700
    ALNDEQKAVR RAIHLAIKQA STDVGQHHKF NTAIAQVMTL MNVLEKAPTA 750
    GEQDRALLQE GLETVALLLA PITPHICHEL WQQLGKPGAI IDAQWPKVDE 800
    AALVQDSLTL VVQVNGKLRG QIEVPASASR EEVETAARGN ENVLRFTEGL 850
    TIRKVIVVPG KLVNIVAN 868
    Length:868
    Mass (Da):96,723
    Last modified:May 20, 2008 - v2
    Checksum:i536449476BCBD0FE
    GO

    Sequence cautioni

    The sequence ABP81391.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000304 Genomic DNA. Translation: ABP81391.1. Different initiation.
    RefSeqiYP_001174233.1. NC_009434.1.

    Genome annotation databases

    EnsemblBacteriaiABP81391; ABP81391; PST_3768.
    GeneIDi5096729.
    KEGGipsa:PST_3768.
    PATRICi19968036. VBIPseStu31643_3747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000304 Genomic DNA. Translation: ABP81391.1 . Different initiation.
    RefSeqi YP_001174233.1. NC_009434.1.

    3D structure databases

    ProteinModelPortali A4VQZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 379731.PST_3768.

    Proteomic databases

    PRIDEi A4VQZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP81391 ; ABP81391 ; PST_3768 .
    GeneIDi 5096729.
    KEGGi psa:PST_3768.
    PATRICi 19968036. VBIPseStu31643_3747.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PSTU379731:GJER-3763-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
      Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
      , Elmerich C., Lin M., Jin Q.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A1501.

    Entry informationi

    Entry nameiSYL_PSEU5
    AccessioniPrimary (citable) accession number: A4VQZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3