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A4VQZ0

- SYL_PSEU5

UniProt

A4VQZ0 - SYL_PSEU5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSTU379731:GJER-3763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PST_3768
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000233: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Leucine--tRNA ligasePRO_0000334796Add
BLAST

Proteomic databases

PRIDEiA4VQZ0.

Interactioni

Protein-protein interaction databases

STRINGi379731.PST_3768.

Structurei

3D structure databases

ProteinModelPortaliA4VQZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi627 – 6315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4VQZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHEQYQPREI EAAAQSHWDS QKSFEVSEQP GKDTFYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VIARYQRMQG KNVLQPMGWD AFGMPAENAA MKNQVAPAKW
110 120 130 140 150
TYENIAYMKA QLKSLGLAID WSREVTTCKP DYYRWEQWLF TRLFEKGVIY
160 170 180 190 200
RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITAYAD
210 220 230 240 250
ELLESLDELD GWPEQVKTMQ RNWIGKSRGM EISFPYDVAS IGNEGVMKVF
260 270 280 290 300
TTRPDTLMGA TYVAVAAEHP LATLAAQHNP ELQAFIDECK RGGVAEADIA
310 320 330 340 350
TQEKKGLATS LRVQHPLTGE LLPVWVANYV LMNYGEGAVM AVPAHDERDF
360 370 380 390 400
EFASKYGLPI KPVVRTSAGD ETPAPWQDAY GEHGQLINSG IYDGLDFEGA
410 420 430 440 450
FDAIEVALQK KGLGQARTQF RLRDWGISRQ RYWGCPIPII HCDSCGDVPV
460 470 480 490 500
PEDQLPVVLP EDVVPDGAGS PLARMPEFYE CTCPKCGAPA KRETDTMDTF
510 520 530 540 550
VESSWYFARY ASPNYDKGMV DPQAANHWLP VDQYIGGIEH AILHLLYARF
560 570 580 590 600
FHKLMRDEGL VSSNEPFKNL LTQGMVVAET YYRTLENGGK DWFNPADVEV
610 620 630 640 650
ERDAKAKVIG ARLKTDGLPV EIGGTEKMSK SKNNGVDPQA MIDAYGADTC
660 670 680 690 700
RLFMMFASPP DMSLEWSDSG VEGASRFLRR VWRLAHAHVS AGLPGALDVA
710 720 730 740 750
ALNDEQKAVR RAIHLAIKQA STDVGQHHKF NTAIAQVMTL MNVLEKAPTA
760 770 780 790 800
GEQDRALLQE GLETVALLLA PITPHICHEL WQQLGKPGAI IDAQWPKVDE
810 820 830 840 850
AALVQDSLTL VVQVNGKLRG QIEVPASASR EEVETAARGN ENVLRFTEGL
860
TIRKVIVVPG KLVNIVAN
Length:868
Mass (Da):96,723
Last modified:May 20, 2008 - v2
Checksum:i536449476BCBD0FE
GO

Sequence cautioni

The sequence ABP81391.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000304 Genomic DNA. Translation: ABP81391.1. Different initiation.
RefSeqiYP_001174233.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP81391; ABP81391; PST_3768.
GeneIDi5096729.
KEGGipsa:PST_3768.
PATRICi19968036. VBIPseStu31643_3747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000304 Genomic DNA. Translation: ABP81391.1 . Different initiation.
RefSeqi YP_001174233.1. NC_009434.1.

3D structure databases

ProteinModelPortali A4VQZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 379731.PST_3768.

Proteomic databases

PRIDEi A4VQZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP81391 ; ABP81391 ; PST_3768 .
GeneIDi 5096729.
KEGGi psa:PST_3768.
PATRICi 19968036. VBIPseStu31643_3747.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PSTU379731:GJER-3763-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
    Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
    , Elmerich C., Lin M., Jin Q.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1501.

Entry informationi

Entry nameiSYL_PSEU5
AccessioniPrimary (citable) accession number: A4VQZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3