Skip Header

Contribute Send feedback
Read comments (?) or add your own

A4VQP7 (A4VQP7_PSEU5) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH-2 EMBL ABP81298.1
Synonyms:ftsH HAMAP-Rule MF_01458
Ordered Locus Names:PST_3675 EMBL ABP81298.1
OrganismPseudomonas stutzeri (strain A1501) [Complete proteome] [HAMAP] EMBL ABP81298.1
Taxonomic identifier379731 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Topological domain1 – 9292Cytoplasmic By similarity HAMAP-Rule MF_01458
Transmembrane93 – 11321Helical; By similarity HAMAP-Rule MF_01458
Topological domain114 – 601488Periplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding185 – 1928ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4091 By similarity HAMAP-Rule MF_01458
Metal binding4081Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4121Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4851Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
A4VQP7 [UniParc].

Last modified May 29, 2007. Version 1.
Checksum: 88B289F5608773EE

FASTA60165,863
        10         20         30         40         50         60 
MIAILVFLGL QYLLSAQQEV ATIPYSEFEQ HLKEGRIEEL AITDRRIEGR LKEPLAGGQR 

        70         80         90        100        110        120 
RFITNRVEPQ LAEHLQQYPV RYTGKVESTL VRDLLSWIVP AMLFFGIWLF LLKRIGSGLG 

       130        140        150        160        170        180 
GGGMMQIGKS KARVYVETDM KVSFADVAGV DEAKDELKEI IEFLRDPQTY GRLGGRMPKG 

       190        200        210        220        230        240 
VLLVGPPGTG KTLLARAVAG EAKVPFFSIS GSEFVELFVG VGAARVRDLF EQARAQAPAI 

       250        260        270        280        290        300 
IFIDELDALG RARGAGPLSG GHDEKEQTLN QLLVEMDGFD TSSGLVLLAA TNRPEILDPA 

       310        320        330        340        350        360 
LLRAGRFDRQ VLVDRPDKVG RVQILNVHLK KSRLGTDVDP QAIAALTPGF TGADLANLVN 

       370        380        390        400        410        420 
EATLLATRRN AEAVAMQDFT AAIERIIAGL EKRNRLLNPR EREIVAYHEM GHALVAMALP 

       430        440        450        460        470        480 
GVDPVHKVSI IPRGMGALGY TIQRPTEDRF LMTREELENK MAVLLGGRAA EWLVFAHLST 

       490        500        510        520        530        540 
GAADDLAKVT DIARAMVTRY GMSTRLGHLA LEREPNAFLG NEALLGLKPQ HDYAESTATA 

       550        560        570        580        590        600 
IDEEVQELVQ AAFQRSLSLL EARRELLERC ARQLLQQETL DAEELRQLSA AAPDAAALPA 


P

« Hide

References

[1]"Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y. expand/collapse author list , Elmerich C., Lin M., Jin Q.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A1501.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000304 Genomic DNA. Translation: ABP81298.1.
RefSeqYP_001174140.1. NC_009434.1.

3D structure databases

ProteinModelPortalA4VQP7.
ModBaseSearch...

Protein-protein interaction databases

STRING379731.PST_3675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP81298; ABP81298; PST_3675.
GeneID5096636.
KEGGpsa:PST_3675.
PATRIC19967844. VBIPseStu31643_3651.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0465.
HOGENOMHOG000217276.
KOK03798.
OMARARASMP.
ProtClustDBCLSK854161.

Enzyme and pathway databases

BioCycPSTU379731:GJER-3670-MONOMER.

Family and domain databases

HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4VQP7_PSEU5
AccessionPrimary (citable) accession number: A4VQP7
Entry history
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 29, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info