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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Pseudomonas stutzeri (strain A1501)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPSTU379731:GJER-2296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:PST_2301Imported
OrganismiPseudomonas stutzeri (strain A1501)Imported
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000233 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi379731.PST_2301.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4VLV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYQKIQVPA SGDKITVNAD NTLNVPDNPI IPYIEGDGIG VDISPVMIKV
60 70 80 90 100
VDAAVQKAYG GKRKIAWMEI YAGEKATQVY DQDTWLPKET LEAVRDYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQELDLYVCQ RPVRWFTGVP SPVKNPGDVD
160 170 180 190 200
MVIFRENSED IYAGVEWKAG SPEAEKVIKF LTEEMGVKKI RFTENCGIGI
210 220 230 240 250
KPVSLEGTKR LVRKALQYAV DNDRDSVTFV HKGNIMKFTE GAFKEWGYEV
260 270 280 290 300
ARDEFGAELL DGGPWMQFKN PNTGKNIVVK DAIADAMLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY LSDALAAEVG GIGIAPGANL SDTVAMFEAT HGTAPKYAGQ
360 370 380 390 400
DKVNPGSLIL SAEMMLRHMG WVEAADLIIK GTEGAIAAKT VTYDFERLME
410
GAQLMSCSQF GDAMISHM
Length:418
Mass (Da):45,647
Last modified:May 29, 2007 - v1
Checksum:i96272348C893E3AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP79960.1.
RefSeqiWP_011913426.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP79960; ABP79960; PST_2301.
KEGGipsa:PST_2301.
PATRICi19965094. VBIPseStu31643_2310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP79960.1.
RefSeqiWP_011913426.1. NC_009434.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi379731.PST_2301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP79960; ABP79960; PST_2301.
KEGGipsa:PST_2301.
PATRICi19965094. VBIPseStu31643_2310.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciPSTU379731:GJER-2296-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
    Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
    , Elmerich C., Lin M., Jin Q.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1501Imported.

Entry informationi

Entry nameiA4VLV9_PSEU5
AccessioniPrimary (citable) accession number: A4VLV9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.