Reviewed, UniProtKB/Swiss-Prot A4VKC2 (BETB_PSEU5)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	PST_1745

Organism

Pseudomonas stutzeri (strain A1501) [Complete proteome] [HAMAP]

Taxonomic identifier

379731 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_1000047051
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4VKC2-1 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: FD5970D8BC7E75E1	FASTA	490	52,389
	10 20 30 40 50 60 MARFPRQQLY IHGAYVDASS NQTFESINPA NGEVLAEVAE AGAADLERAV ESAEQGQRIW 70 80 90 100 110 120 AALTGIERAR IMRRAVDLLR ERNDELALLE TLDTGKPLSE TRSVDIITGA DVLEYYAGLA 130 140 150 160 170 180 PAIEGEQIPL RDSSFVYTRR EPLGVVAGIG AWNYPIQIAL WKAAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TPLSALRLAE IFSEAGLPDG VFNVLTGSGA GVGALITEHP RIAKVSFTGG VATGKKVMAS 250 260 270 280 290 300 AAGSSLKDVT MELGGKSPLI VCEDADLDRA ADIAVMANFF SSGQVCTNGT RVFIPAGLKA 310 320 330 340 350 360 SFEAKLLERV QRVRLGDPQQ EATNFGPLVS FAHMDKVLDY IAQGKAAGAR ILCGGERVTE 370 380 390 400 410 420 GEYARGAFVA PTIFSDCSDD MSIVREEIFG PVLSLLEYQG EDEAIRRAND TEYGLAAGVV 430 440 450 460 470 480 TPDLARAHRI IHRLEAGICW INTWGESPAQ MPVGGYKQSG IGRENGIASL AHYTRVKSVQ 490 VELGEFASVF

References

[1]

"Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501." Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y. , Elmerich C., Lin M., Jin Q. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000304 Genomic DNA. Translation: ABP79423.1.
RefSeq	YP_001172265.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5097829.
GenomeReviews	Gene locus PST_1745 in contig CP000304_GR.
KEGG	psa:PST_1745.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A4VKC2. IERARIM.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_PSEU5

Accession

Primary (citable) accession number: A4VKC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 29, 2007
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)