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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei97 – 971Transition state stabilizerUniRule annotation
Active sitei101 – 1011Proton acceptorUniRule annotation
Metal bindingi263 – 2631Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPSTU379731:GJER-1628-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PST_1629
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000233 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Catalase-peroxidasePRO_0000354870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki100 ↔ 222Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-248)UniRule annotation
Cross-linki222 ↔ 248Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-100)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA4VK13.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi379731.PST_1629.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4VK13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAESGENAG GGCPLGHGAG APRKRPSNRD WWPEALSLTS LNQHSPRSNP
60 70 80 90 100
YGGDFDYAAE FNSLDLDAVI ADLHKVMTDS QDWWPADFGH YGGLFIRMAW
110 120 130 140 150
HSAGTYRITD GRGGAGGGQQ RFAPLNSWPD NASLDKARRL LWPIKQKYGR
160 170 180 190 200
KLSWADLFVL TGNVALESMG FKTFGFGGGR ADTWEPEELF WGPEGTWLGD
210 220 230 240 250
ERYSGERQLH PGLGAVQMGL IYVNPEGPNG NPDPKAAAVD IRETFARMAM
260 270 280 290 300
NDYETVALIA GGHTFGKTHG AGDPSFIGPE PEGALIEDQG LGWRSKFQTG
310 320 330 340 350
IGPDAITSGL EVIWSQTPVK WSNYFFENLF NFEWELTKSP AGAHQWVAKD
360 370 380 390 400
APEIIPDPFD PNKKRKPTML TTDLSLRFDP IYEPISRHFL ENPDEFADAF
410 420 430 440 450
ARAWFKLTHR DMGPIARYLG PLVPKEQLIW QDPIPERDHP VIDDADIASL
460 470 480 490 500
KQKILGLGFS VSDLVSVAWA SAATYRGSDK RGGANGARIR FAPQKDWEIN
510 520 530 540 550
NPPLLAQVLQ KLGEIQSDFN GSATGGKKVS MADLIVLAGC AAIEKAAQDG
560 570 580 590 600
GVNVAVPFTP GRMDALEEWT DAQSFEALRP VADGFRNYYH ESHFMAPEEA
610 620 630 640 650
LVDKAHLLRL SAPEMTVLVG GMRVLGANAG GSQDGVFTHR VGVLSNDFFV
660 670 680 690 700
NLLDMKNEWT ATEHKNRFQG LDRKTRQPTW TATRVDLIFG SQSELRAQAE
710 720 730 740
VYGMADGNEK FVRDFAKAWD KVMNADRMDI GKPADQFSQK LSA
Length:743
Mass (Da):81,903
Last modified:May 29, 2007 - v1
Checksum:i907DF5667F2A4B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP79314.1.
RefSeqiWP_011912791.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP79314; ABP79314; PST_1629.
GeneIDi25043118.
KEGGipsa:PST_1629.
PATRICi19963721. VBIPseStu31643_1640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP79314.1.
RefSeqiWP_011912791.1. NC_009434.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi379731.PST_1629.

Proteomic databases

PRIDEiA4VK13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP79314; ABP79314; PST_1629.
GeneIDi25043118.
KEGGipsa:PST_1629.
PATRICi19963721. VBIPseStu31643_1640.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciPSTU379731:GJER-1628-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501."
    Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y.
    , Elmerich C., Lin M., Jin Q.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1501.

Entry informationi

Entry nameiKATG_PSEU5
AccessioniPrimary (citable) accession number: A4VK13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 29, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.