A4VHV6 (TYPH_PSEU5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

PST_0860

Organism

Pseudomonas stutzeri (strain A1501) [Complete proteome] [HAMAP]

Taxonomic identifier

379731 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas stutzeri group › Pseudomonas stutzeri subgroup › Pseudomonas stutzeri

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence caution	The sequence ABP78557.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314707

Sequences

	Sequence		Length	Mass (Da)
	A4VHV6 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 8919244A6B4B3662	FASTA	526	56,665
	10 20 30 40 50 60 MTSISSDTPL NGKAPVHLAL RRVAIDTYRE NVAYLHRDCA ACRAEGFQAL AKVEIRVNGR 70 80 90 100 110 120 RILASLNLVD DPSIVGCDEL GLSEDAFAQL GAEAGVPAAI AQAEPAASIP ALHRKIAGER 130 140 150 160 170 180 LNRDDFLAIM RDIAEHRYSK IELTAFVVAC NQGELDREEV FFLTDAMIRV GRRLDWREHP 190 200 210 220 230 240 VVDKHCIGGI PGNRTSMLVV PIVAAHGMLC PKTSSRAITS PAGTADTMEV LANVELPFER 250 260 270 280 290 300 LCEMVREERG CLAWGGSSDL SPADDVLIAV ERPLSIDSPG QMVASILSKK IAAGSTHLLL 310 320 330 340 350 360 DIPIGPTAKV RSMAEAQRLR KLFEFVATRL GLTLDVVITD GRQPIGNGIG PVLEARDVIQ 370 380 390 400 410 420 VLQNDPAAPI DLRQKALRLA GRMLEFDPDV RGGDGYAIAR DILDSGRALK KMRSIIAAQG 430 440 450 460 470 480 GKPFDHNHPP LARLSFDVLA DCDAVVTGID NLQLARIARL AGAPKVQGAG VDILRKLGEP 490 500 510 520 VRAGDCLYRV YADFPADLAF ARQATERASG VSLGSPEQVP TVFVEF

References

[1]

"Complete genome sequence of the metabolically versatile and root-associated nitrogen-fixing bacterium Pseudomonas stutzeri A1501." Yan Y., Yang J., Dou Y., Ping S., Chen M., Yao Z., Li H., Lu W., Zhang W., Peng J., Liu W., He S., Geng L., Zhang X., Yang F., Li D., Lin Z., Wang Y. , Elmerich C., Lin M., Jin Q. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A1501.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000304 Genomic DNA. Translation: ABP78557.1. Different initiation.
RefSeq	YP_001171399.1. NC_009434.1.
3D structure databases
ProteinModelPortal	A4VHV6.
ModBase	Search...
Protein-protein interaction databases
STRING	379731.PST_0860.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP78557; ABP78557; PST_0860.
GeneID	5098530.
KEGG	psa:PST_0860.
PATRIC	19962135. VBIPseStu31643_0854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	PSTU379731:GJER-861-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_PSEU5

Accession

Primary (citable) accession number: A4VHV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program