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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Pseudomonas stutzeri (strain A1501)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:PST_0409
OrganismiPseudomonas stutzeri (strain A1501)
Taxonomic identifieri379731 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000233 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000219751 – 159RNA pyrophosphohydrolaseAdd BLAST159

Interactioni

Protein-protein interaction databases

STRINGi379731.PST_0409.

Structurei

3D structure databases

ProteinModelPortaliA4VGL4.
SMRiA4VGL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 149Nudix hydrolaseUniRule annotationAdd BLAST144

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066723.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiPOG091H0392.

Family and domain databases

CDDicd03671. Ap4A_hydrolase_plant_like. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

A4VGL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSDGFRPN VGIILTNDVG QVLWARRINQ DAWQFPQGGI NARETPEEAL
60 70 80 90 100
FRELNEEVGL EEQDVKILAC TRGWLRYRLP QRLVRTHSQP LCIGQKQKWF
110 120 130 140 150
LLRLTGAEDR VRMDLTGKPE FDGWRWVSYW YPLGQVVTFK REVYRRALKE

LAPRLPVRD
Length:159
Mass (Da):18,752
Last modified:May 29, 2007 - v1
Checksum:iFB07EE60298C6F92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000304 Genomic DNA. Translation: ABP78115.1.
RefSeqiWP_011911645.1. NC_009434.1.

Genome annotation databases

EnsemblBacteriaiABP78115; ABP78115; PST_0409.
GeneIDi28545073.
KEGGipsa:PST_0409.

Similar proteinsi

Entry informationi

Entry nameiRPPH_PSEU5
AccessioniPrimary (citable) accession number: A4VGL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 29, 2007
Last modified: September 27, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families