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Protein

Histone deacetylase

Gene

TTHERM_00663829

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115SubstrateUniRule annotation1
Active sitei157Proton acceptorUniRule annotation1
Binding sitei165Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi192Divalent metal cationUniRule annotation1
Metal bindingi194Divalent metal cationUniRule annotation1
Metal bindingi281Divalent metal cationUniRule annotation1
Binding sitei320SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:TTHERM_00663829Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
Proteomesi
  • UP000009168 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi5911.EDK31538.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 332Hist_deacetylInterPro annotationAdd BLAST309

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiA4VDD9.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A4VDD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKKKVAYF YNNEIGNYNY GKLHLMNPKR ISMTHSLIVG YGVYKDLDVY
60 70 80 90 100
TTREATKEEI MQFHDQDYVE YLSNYVSSSK IDFLKKNGCS IPLIDEDAKN
110 120 130 140 150
DSDKKKQYGI DVQADCPGFD GLYTFSQLST GGSIDAAHLI INNAADIAIN
160 170 180 190 200
WGGGLHHAKK GEAYGFCYVN DIVICILELL KVFPRVLYID IDVHHGDGVE
210 220 230 240 250
EAFYTTNRVM TVSFHEFGED FFPGTGGLNS NGEGLGKNYA VNVPLRPGMD
260 270 280 290 300
DESYVQLFKN VMNKVMEVYR PDVVVFQTGA DSLANDKIGH FNLSIKGHGQ
310 320 330 340 350
CLTYMMGFNV PLVVLGGGGY TIQNVSRCWA FETGLLVKKS LNGPIPVDDP
360 370 380 390 400
FFHLYEKQNV LHVPIQQVEN KNSKEDLNKI QEEIFKQLKD VEAAPGVPFH
410 420 430 440 450
TVPRTFLYDD EEYFDEHEMD KNHDYDGNNY DQDKLNDYIN GYHQMDIEQN
460 470
DQNEIIRKSP LLIEKRNKFN HI
Length:472
Mass (Da):53,744
Last modified:April 16, 2014 - v2
Checksum:i4A2564264CA7B0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662634 Genomic DNA. Translation: EDK31538.2.
RefSeqiXP_001470889.2. XM_001470839.2.

Genome annotation databases

EnsemblProtistsiEDK31538; EDK31538; TTHERM_00663829.
GeneIDi7835895.
KEGGitet:TTHERM_00663829.

Similar proteinsi

Entry informationi

Entry nameiA4VDD9_TETTS
AccessioniPrimary (citable) accession number: A4VDD9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: April 16, 2014
Last modified: August 30, 2017
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported