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A4VDD9

- A4VDD9_TETTS

UniProt

A4VDD9 - A4VDD9_TETTS

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Protein

Histone deacetylase

Gene

TTHERM_00663829

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:TTHERM_00663829Imported
OrganismiTetrahymena thermophila (strain SB210)Imported
Taxonomic identifieri312017 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
ProteomesiUP000009168: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5911.XP_001470889.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiA4VDD9.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A4VDD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METKKKVAYF YNNEIGNYNY GKLHLMNPKR ISMTHSLIVG YGVYKDLDVY
60 70 80 90 100
TTREATKEEI MQFHDQDYVE YLSNYVSSSK IDFLKKNGCS IPLIDEDAKN
110 120 130 140 150
DSDKKKQYGI DVQADCPGFD GLYTFSQLST GGSIDAAHLI INNAADIAIN
160 170 180 190 200
WGGGLHHAKK GEAYGFCYVN DIVICILELL KVFPRVLYID IDVHHGDGVE
210 220 230 240 250
EAFYTTNRVM TVSFHEFGED FFPGTGGLNS NGEGLGKNYA VNVPLRPGMD
260 270 280 290 300
DESYVQLFKN VMNKVMEVYR PDVVVFQTGA DSLANDKIGH FNLSIKGHGQ
310 320 330 340 350
CLTYMMGFNV PLVVLGGGGY TIQNVSRCWA FETGLLVKKS LNGPIPVDDP
360 370 380 390 400
FFHLYEKQNV LHVPIQQVEN KNSKEDLNKI QEEIFKQLKD VEAAPGVPFH
410 420 430 440 450
TVPRTFLYDD EEYFDEHEMD KNHDYDGNNY DQDKLNDYIN GYHQMDIEQN
460 470
DQNEIIRKSP LLIEKRNKFN HI
Length:472
Mass (Da):53,744
Last modified:April 16, 2014 - v2
Checksum:i4A2564264CA7B0DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662634 Genomic DNA. Translation: EDK31538.2.

Genome annotation databases

EnsemblProtistsiEDK31538; EDK31538; TTHERM_00663829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG662634 Genomic DNA. Translation: EDK31538.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.XP_001470889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi EDK31538 ; EDK31538 ; TTHERM_00663829 .

Phylogenomic databases

InParanoidi A4VDD9.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote."
    Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M.
    , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E.
    PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB210Imported.

Entry informationi

Entry nameiA4VDD9_TETTS
AccessioniPrimary (citable) accession number: A4VDD9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 29, 2007
Last sequence update: April 16, 2014
Last modified: October 29, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3