A4VDD9 (A4VDD9_TETTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone deacetylase PIRNR PIRNR037913
EC=3.5.1.98 PIRNR PIRNR037913

Gene names

ORF Names:

TTHERM_00663829 EMBL EDK31538.1

Organism

Tetrahymena thermophila (strain SB210) [Reference proteome] EMBL EDK31538.1

Taxonomic identifier

312017 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena › Tetrahymena thermophila

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913
Subcellular location	Nucleus By similarity PIRNR PIRNR037913.
Sequence similarities	Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR037913
Cellular component	Nucleus PIRNR PIRNR037913
Molecular function	Chromatin regulator PIRNR PIRNR037913 Hydrolase PIRNR PIRNR037913 SAAS SAAS000286
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4VDD9 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: 833B9E60B14FDCC8	FASTA	473	53,801
	10 20 30 40 50 60 METKKKVAYF YNNEIGNYNY GKLHLMNPKR ISMTHSLIVG YGVYKDLDVY TTREATKEEI 70 80 90 100 110 120 MQFHDQDYVE YLSNYVSSSK IDFLKKNGCS IPLIDEDAKN DSDKKKQYGI DVQADCPGFD 130 140 150 160 170 180 GLYTFSQLST GGGSIDAAHL IINNAADIAI NWGGGLHHAK KGEAYGFCYV NDIVICILEL 190 200 210 220 230 240 LKVFPRVLYI DIDVHHGDGV EEAFYTTNRV MTVSFHEFGE DFFPGTGGLN SNGEGLGKNY 250 260 270 280 290 300 AVNVPLRPGM DDESYVQLFK NVMNKVMEVY RPDVVVFQTG ADSLANDKIG HFNLSIKGHG 310 320 330 340 350 360 QCLTYMMGFN VPLVVLGGGG YTIQNVSRCW AFETGLLVKK SLNGPIPVDD PFFHLYEKQN 370 380 390 400 410 420 VLHVPIQQVE NKNSKEDLNK IQEEIFKQLK DVEAAPGVPF HTVPRTFLYD DEEYFDEHEM 430 440 450 460 470 DKNHDYDGNN YDQDKLNDYI NGYHQMDIEQ NDQNEIIRKS PLLIEKRNKF NHI

References

[1]

"Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote." Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M. , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E. PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG662634 Genomic DNA. Translation: EDK31538.1.
RefSeq	XP_001470889.1. XM_001470839.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	EDK31538; EDK31538; TTHERM_00663829.
GeneID	7835895.
KEGG	tet:TTHERM_00663829.
Phylogenomic databases
KO	K06067.
ProtClustDB	CLSZ2449804.
Family and domain databases
Gene3D	3.40.800.20. 1 hit.
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

A4VDD9_TETTS

Accession

Primary (citable) accession number: A4VDD9

Entry history

Integrated into UniProtKB/TrEMBL:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	March 6, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)