A4UZ51 (A4UZ51_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ecdysone receptor, isoform E EMBL AAM68346.1

Gene names

Name:	EcR FlyBase FBgn0000546
ORF Names:	Dmel_CG1765 EMBL AAM68346.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	849 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS008946
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS008946
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS008946
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS008946 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL AAM68346.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ecdysteroid hormone receptor activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4UZ51 [UniParc]. Last modified May 29, 2007. Version 1. Checksum: E93D93A38236AD58	FASTA	849	91,182
	10 20 30 40 50 60 MLTTSGQQQS KQKLSTLPSH ILLQQQLAAS AGPSSSVSLS PSSSAALTLH VASANGGARE 70 80 90 100 110 120 TTSAAAVKDK LRPTPTAIKI EPMPDVISVG TVAGGSSVAT VVAPAATTTS NKPNSTAAPS 130 140 150 160 170 180 TSAAAANGHL VLVPNKRPRL DVTEDWMSTP SPGSVPSSAP PLSPSPGSQN HSYNMSNGYA 190 200 210 220 230 240 SPMSAGSYDP YSPTGKTGRD DLSPSSSLNG YSANESCDAK KSKKGPAPRV QEELCLVCGD 250 260 270 280 290 300 RASGYHYNAL TCEGCKGFFR RSVTKSAVYC CKFGRACEMD MYMRRKCQEC RLKKCLAVGM 310 320 330 340 350 360 RPECVVPENQ CAMKRREKKA QKEKDKMTTS PSSQHGGNGS LASGGGQDFV KKEILDLMTC 370 380 390 400 410 420 EPPQHATIPL LPDEILAKCQ ARNIPSLTYN QLAVIYKLIW YQDGYEQPSE EDLRRIMSQP 430 440 450 460 470 480 DENESQTDVS FRHITEITIL TVQLIVEFAK GLPAFTKIPQ EDQITLLKAC SSEVMMLRMA 490 500 510 520 530 540 RRYDHSSDSI FFANNRSYTR DSYKMAGMAD NIEDLLHFCR QMFSMKVDNV EYALLTAIVI 550 560 570 580 590 600 FSDRPGLEKA QLVEAIQSYY IDTLRIYILN RHCGDSMSLV FYAKLLSILT ELRTLGNQNA 610 620 630 640 650 660 EMCFSLKLKN RKLPKFLEEI WDVHAIPPSV QSHLQITQEE NERLERAERM RASVGGAITA 670 680 690 700 710 720 GIDCDSASTS AAAAAAQHQP QPQPQPQPSS LTQNDSQHQT QPQLQPQLPP QLQGQLQPQL 730 740 750 760 770 780 QPQLQTQLQP QIQPQPQLLP VSAPVPASVT APGSLSAVST SSEYMGGSAA IGPITPATTS 790 800 810 820 830 840 SITAAVTASS TTSAVPMGNG VGVGVGVGGN VSMYANAQTA MALMGVALHS HQEQLIGGVA VKSEHSTTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAM68346.1.
RefSeq	NP_724456.1. NM_165461.2. NP_724457.1. NM_165462.2. NP_724458.1. NM_165463.2.
UniGene	Dm.4159.
3D structure databases
ProteinModelPortal	A4UZ51.
SMR	A4UZ51. Positions 229-623.
ModBase	Search...
Protein-protein interaction databases
STRING	A4UZ51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0086008; FBpp0085349; FBgn0000546. FBtr0086009; FBpp0085350; FBgn0000546. FBtr0086010; FBpp0085351; FBgn0000546.
GeneID	35540.
KEGG	dme:Dmel_CG1765.
UCSC	CG1765-RE. d. melanogaster.
Organism-specific databases
CTD	35540.
FlyBase	FBgn0000546. EcR.
Phylogenomic databases
GeneTree	EMGT00070000025663.
InParanoid	A4UZ51.
OMA	MALMGVP.
Gene expression databases
Bgee	A4UZ51.
Family and domain databases
InterPro	IPR003069. Ecdystd_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 2 hits. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
KO	K14034.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01283. ECDYSTEROIDR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	793933.

Entry information

Entry name

A4UZ51_DROME

Accession

Primary (citable) accession number: A4UZ51

Entry history

Integrated into UniProtKB/TrEMBL:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)