Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fatty acid desaturase 1

Gene

FADS1

Organism
Papio anubis (Olive baboon)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively. Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.1 Publication

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Enzyme and pathway databases

UniPathwayiUPA00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid desaturase 1 (EC:1.14.19.-)
Alternative name(s):
Delta(5) fatty acid desaturase
Short name:
D5D
Short name:
Delta(5) desaturase
Short name:
Delta-5 desaturase
Gene namesi
Name:FADS1
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Unplaced

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 121CytoplasmicSequence analysisAdd BLAST121
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 146LumenalSequence analysis4
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 267CytoplasmicSequence analysisAdd BLAST100
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 305LumenalSequence analysisAdd BLAST17
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 444CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003070981 – 444Fatty acid desaturase 1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, liver and thymus (at protein level). Isoform 1 seems to be more abundant than isoform 2. Expression of isoform 2 is very low in spleen and not detectable in skeletal muscle.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA4UVI1.
SMRiA4UVI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 94Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 183Histidine box-15
Motifi216 – 220Histidine box-25
Motifi382 – 386Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002839.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4UVI1-1) [UniParc]FASTAAdd to basket
Also known as: FADS1CS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPDPVAAKT PVQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYDISEFTR
60 70 80 90 100
RHPGGSRVIS HYAGQDATDP FVAFHSNKGL VKKYMNSLLI GELSPEQPSF
110 120 130 140 150
EPTKNKELTD EFRELRATVE QMGLMKANHV FFLLYLLHIL LLDGAAWLTL
160 170 180 190 200
WIFGTSFLPF LLCAVLLTAA QIQAGWLQHD LGHLSVFSTS KWNHLVHHFV
210 220 230 240 250
IGHLKGVPAS WWNHMHFQHH AKPNCFGKDP DINMHPFFFA LGKILSVELG
260 270 280 290 300
KQKKKYMPYN HQHKYFFLIG PPALVPFFFQ WYVFYFVIQR KKWVDLAWMI
310 320 330 340 350
TFYIRLLLTY VPLLGLKAFL GLYFIVRFLE SNWFVWVTQM NHIPMHIDHD
360 370 380 390 400
RNMDWVSTQL QATCNVHKSA FNDWFSGHLN FQIEHHLFPM MPRHNYHKVA
410 420 430 440
PLVQSLCAKH GIEYQSKPLL SAFADIIHSL KESGQLWLDA YLHQ
Length:444
Mass (Da):51,869
Last modified:May 15, 2007 - v1
Checksum:i6D2BDD805FB38A8A
GO
Isoform 2 (identifier: A4UVI1-2) [UniParc]FASTAAdd to basket
Also known as: FADS1AT1

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:360
Mass (Da):42,351
Checksum:i90A6DA5558A90C2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti425D → N in AFC78250 (PubMed:22619218).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0534441 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ779578 mRNA. Translation: ABG77281.1.
EF531577 mRNA. Translation: ABP06289.1.
HQ440212 mRNA. Translation: ADQ89961.1.
JF518968 mRNA. Translation: AFC78250.1.
JF518969 mRNA. Translation: AFC78251.1.
JF518970 mRNA. Translation: AFC78252.1.
JF518971 mRNA. Translation: AFC78253.1.
JF518972 mRNA. Translation: AFC78254.1.
JF518974 mRNA. Translation: AFC78256.1.
RefSeqiNP_001106097.1. NM_001112627.1. [A4UVI1-1]
UniGeneiPan.11063.

Genome annotation databases

GeneIDi100126707.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ779578 mRNA. Translation: ABG77281.1.
EF531577 mRNA. Translation: ABP06289.1.
HQ440212 mRNA. Translation: ADQ89961.1.
JF518968 mRNA. Translation: AFC78250.1.
JF518969 mRNA. Translation: AFC78251.1.
JF518970 mRNA. Translation: AFC78252.1.
JF518971 mRNA. Translation: AFC78253.1.
JF518972 mRNA. Translation: AFC78254.1.
JF518974 mRNA. Translation: AFC78256.1.
RefSeqiNP_001106097.1. NM_001112627.1. [A4UVI1-1]
UniGeneiPan.11063.

3D structure databases

ProteinModelPortaliA4UVI1.
SMRiA4UVI1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100126707.

Organism-specific databases

CTDi3992.

Phylogenomic databases

HOVERGENiHBG002839.

Enzyme and pathway databases

UniPathwayiUPA00658.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFADS1_PAPAN
AccessioniPrimary (citable) accession number: A4UVI1
Secondary accession number(s): F1CNE5
, L7NWK4, L7NWR0, Q0PR60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.