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Protein

Phosphoprotein

Gene

P

Organism
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion, Viral RNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoprotein
Short name:
Protein P
Alternative name(s):
Protein M1
Gene namesi
Name:P
OrganismiEuropean bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2)
Taxonomic identifieri453116 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiMammalia [TaxID: 40674]
Proteomesi
  • UP000007206 Componenti: Genome

Subcellular locationi

Isoform P3 :
Isoform P5 :

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990961 – 297PhosphoproteinAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210Phosphoserine; by host PKCBy similarity1
Modified residuei271Phosphoserine; by host PKCBy similarity1

Post-translational modificationi

Phosphorylated by host PKC and by an unknown kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA4UHQ4

Interactioni

Subunit structurei

Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host STAT1, STAT2, DYNLL1, DYNLL2 and PML. Isoform P3 binds host PML (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliA4UHQ4
SMRiA4UHQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 58Nuclear export signalBy similarity10
Motifi211 – 214Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the lyssavirus protein P family.Curated

Phylogenomic databases

OrthoDBiVOG090000H9

Family and domain databases

Gene3Di1.20.120.820, 1 hit
InterProiView protein in InterPro
IPR004259 PP_M1
IPR037199 PP_M1_C
PfamiView protein in Pfam
PF03012 PP_M1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004155 PP_M1, 1 hit
SUPFAMiSSF118173 SSF118173, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform P (identifier: A4UHQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKIFVNPSA IRAGLADLEM AEETVDLVNK NIEDNQAHLQ GEPIEVDALP
60 70 80 90 100
EDMSKLQISE RRPAQFTDNT GGKEEGSDED FYMAESEDPY IPLQSYLEGV
110 120 130 140 150
GIQLVRQMKT GERFFKIWSQ AVEEIISYVT VHFPMPLGKS TEDKSTQTPE
160 170 180 190 200
EKFKPSPQQA VTKKESQSSK IKTISQESSG PPALEWSTTN DEENASVEAE
210 220 230 240 250
IAHQIAESFS KKYKFPSRSS GIFLFNFEQL KMNLDDIVKE AKKIPGVVRL
260 270 280 290
AQDGFRLPLR CILGGVGSVN SKKFQLLVNS DKLGKIMQDD LNRYLAY
Length:297
Mass (Da):33,322
Last modified:November 11, 2015 - v2
Checksum:iA8859B461A175DB8
GO
Isoform P2 (identifier: A4UHQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:278
Mass (Da):31,307
Checksum:i0D12C61643E2D7A2
GO
Isoform P3 (identifier: A4UHQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:245
Mass (Da):27,648
Checksum:i53F71BD950260AFC
GO
Isoform P5 (identifier: A4UHQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:215
Mass (Da):24,230
Checksum:iE086E2CA5B5C307D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti153F → S in strain: Isolate Switzerland/V286/1992. 1
Natural varianti239K → R in strain: Isolate Switzerland/V286/1992. 1
Natural varianti253D → I in strain: Isolate Switzerland/V286/1992. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0275581 – 82Missing in isoform P5. CuratedAdd BLAST82
Alternative sequenceiVSP_0275591 – 52Missing in isoform P3. CuratedAdd BLAST52
Alternative sequenceiVSP_0275601 – 19Missing in isoform P2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049121 mRNA Translation: AAC04591.1
EF157977 Genomic RNA Translation: ABO65249.2
RefSeqiYP_001285394.2, NC_009528.2

Genome annotation databases

GeneIDi5219914
KEGGivg:5219914

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiPHOSP_EBLV2
AccessioniPrimary (citable) accession number: A4UHQ4
Secondary accession number(s): O56780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 11, 2015
Last modified: May 23, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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