A4UGR9 (XIRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xin actin-binding repeat-containing protein 2

Alternative name(s):
Beta-xin
Cardiomyopathy-associated protein 3
Xeplin

Gene names

Name:	XIRP2
Synonyms:	CMYA3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3374 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protects actin filaments from depolymerization. Ref.7
Subunit structure	Interacts with ACTN2 By similarity. Interacts with F-actin. Ref.7
Subcellular location	Cell junction. Note: Colocalizes with actin stress fibers By similarity. Ref.7
Domain	Xin repeats bind F-actin.
Miscellaneous	'Xin' means 'heart' in Chinese.
Sequence similarities	Belongs to the Xin family. Contains 28 Xin repeats.
Sequence caution	The sequence AAH18673.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAY24138.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAD38624.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence CAD89958.1 differs from that shown. Reason: Contaminating sequence. The sequence CAD91141.2 differs from that shown. Reason: Contaminating sequence.

Ontologies

Keywords
Cellular component	Cell junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A4UGR9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A4UGR9-2) The sequence of this isoform differs from the canonical sequence as follows:      1-47: Missing.
Isoform 3 (identifier: A4UGR9-3) The sequence of this isoform differs from the canonical sequence as follows:      3344-3345: EA → GK      3346-3374: Missing.
Isoform 4 (identifier: A4UGR9-4) The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MFPMQKGSLN...KGKETSFDKM      218-771: TESEYEETFK...LEEVDRGDVK → KLLLQDKEIC...KRNRCYSDTE      772-3374: Missing.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	757	1	R → G. Corresponds to variant rs3749005 [ dbSNP | Ensembl ].
	Natural variant	885	1	V → G. Corresponds to variant rs3749006 [ dbSNP | Ensembl ].
	Natural variant	905	1	E → Q. Corresponds to variant rs16853344 [ dbSNP | Ensembl ].
Isoform 5 (identifier: A4UGR9-5) The sequence of this isoform differs from the canonical sequence as follows:      218-771: TESEYEETFK...LEEVDRGDVK → KLLLQDKEIC...KRNRCYSDTE      772-3374: Missing.
Isoform 6 (identifier: A4UGR9-6) The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MFPMQKGSLN...KGKETSFDKM      13-13: A → AVFSTDQAQILRLHLHPKLTKTPKNSLKSSTYIS      218-771: TESEYEETFK...LEEVDRGDVK → KLLLQDKEIC...KRNRCYSDTE      772-3374: Missing.
Isoform 7 (identifier: A4UGR9-7) The sequence of this isoform differs from the canonical sequence as follows:      1-47: Missing.      218-771: TESEYEETFK...LEEVDRGDVK → KLLLQDKEIC...KRNRCYSDTE      772-3374: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3374	3374	Xin actin-binding repeat-containing protein 2		PRO_0000316987
Regions
	Repeat	362 – 377	16	Xin 1
	Repeat	397 – 412	16	Xin 2
	Repeat	437 – 452	16	Xin 3
	Repeat	474 – 489	16	Xin 4
	Repeat	512 – 527	16	Xin 5
	Repeat	552 – 567	16	Xin 6
	Repeat	590 – 605	16	Xin 7
	Repeat	628 – 643	16	Xin 8
	Repeat	661 – 676	16	Xin 9
	Repeat	695 – 710	16	Xin 10
	Repeat	732 – 747	16	Xin 11
	Repeat	768 – 783	16	Xin 12
	Repeat	799 – 814	16	Xin 13
	Repeat	837 – 852	16	Xin 14
	Repeat	875 – 890	16	Xin 15
	Repeat	914 – 929	16	Xin 16
	Repeat	947 – 962	16	Xin 17
	Repeat	985 – 1000	16	Xin 18
	Repeat	1020 – 1035	16	Xin 19
	Repeat	1059 – 1074	16	Xin 20
	Repeat	1095 – 1110	16	Xin 21
	Repeat	1132 – 1147	16	Xin 22
	Repeat	1170 – 1185	16	Xin 23
	Repeat	1207 – 1222	16	Xin 24
	Repeat	1241 – 1256	16	Xin 25
	Repeat	1272 – 1287	16	Xin 26
	Repeat	1310 – 1325	16	Xin 27
	Repeat	1345 – 1360	16	Xin 28
	Coiled coil	1736 – 1763	28	Potential
	Coiled coil	2369 – 2394	26	Potential
	Coiled coil	2768 – 2792	25	Potential
	Coiled coil	2823 – 2849	27	Potential
	Compositional bias	278 – 282	5	Poly-Pro
	Compositional bias	1036 – 1041	6	Poly-Ser
	Compositional bias	2113 – 2201	89	Pro-rich
Natural variations
	Alternative sequence	1 – 47	47	Missing in isoform 2 and isoform 7.		VSP_030846
	Alternative sequence	1	1	M → MFPMQKGSLNLLRQKWESCD YQRSECHPRDSHCTIFQPQE SKLLAPEGEVVSAPQSLDPT SLPYSTGEEMWSSKPEEKDS VDKSNNTREYGRPEVLKEDS LSSRRRIERFSIALDELRSV FEAPKSGNKPAEYGGKEVEI ERSLCSPAFKSHPGSQLEDS VKDSDKKGKETSFDKM in isoform 4 and isoform 6.		VSP_035717
	Alternative sequence	13	1	A → AVFSTDQAQILRLHLHPKLT KTPKNSLKSSTYIS in isoform 6.		VSP_035718
	Alternative sequence	218 – 771	554	TESEY…RGDVK → KLLLQDKEICILCQKTVYPM ECLVADKQNFHKSCFRCHHC NSKLSLGNYASLHGQIYCKP HFKQLFKSKGNYDEGFGHKQ HKDRWNCKNQSRSVDFIPNE EPNMCKNIAENTLVPGDRNE HLDAGNSEGQRNDLRKLGER GKLKVIWPPSKEIPKKTLPF EEELKMSKPKWPPEMTTLLS PEFKSESLLEDVRTPENKGQ RQDHFPFLQPYLQSTHVCQK EDVIGIKEMKMPEGRKDEKK EGRKNVQDRPSEAEDTKSNR KSAMDLNDNNNVIVQSAEKE KNEKTNQTNGAEVLQVTNTD DEMMPENHKENLNKNNNNNY VAVSYLNNCRQKTSILEFLD LLPLSSEANDTANEYEIEKL ENTSRISELLGIFESEKTYS RNVLAMALKKQTDRAAAGSP VQPAPKPSLSRGLMVKGGSS IISPDTNLLNIKGSHSKSKN LHFFFSNTVKITAFSKKNEN IFNCDLIDSVDQIKNMPCLD LREFGKDVKPWHVETTEAAR NNENTGFDALSHECTAKPLF PRVEVQSEQLTVEEQIKRNR CYSDTE in isoform 4, isoform 5, isoform 6 and isoform 7.		VSP_035719
	Alternative sequence	772 – 3374	2603	Missing in isoform 4, isoform 5, isoform 6 and isoform 7.		VSP_035720
	Alternative sequence	3344 – 3345	2	EA → GK in isoform 3.		VSP_030847
	Alternative sequence	3346 – 3374	29	Missing in isoform 3.		VSP_030848
	Natural variant	450	1	P → A. Corresponds to variant rs16853305 [ dbSNP | Ensembl ].		VAR_038449
	Natural variant	457	1	Y → H. Corresponds to variant rs16853306 [ dbSNP | Ensembl ].		VAR_038450
	Natural variant	1397	1	I → T. Corresponds to variant rs7588159 [ dbSNP | Ensembl ].		VAR_038451
	Natural variant	1488	1	I → T. Corresponds to variant rs7591107 [ dbSNP | Ensembl ].		VAR_038452
	Natural variant	1626	1	R → H. Corresponds to variant rs16853309 [ dbSNP | Ensembl ].		VAR_038453
	Natural variant	1833	1	N → S. Corresponds to variant rs7607246 [ dbSNP | Ensembl ].		VAR_038454
	Natural variant	2423	1	L → R. Corresponds to variant rs16853326 [ dbSNP | Ensembl ].		VAR_038455
	Natural variant	2553	1	S → N. Corresponds to variant rs16853328 [ dbSNP | Ensembl ].		VAR_038456
	Natural variant	2595	1	H → Y. Corresponds to variant rs16853329 [ dbSNP | Ensembl ].		VAR_038457
	Natural variant	2607	1	V → I. Corresponds to variant rs16853330 [ dbSNP | Ensembl ].		VAR_038458
	Natural variant	2728	1	G → D. Corresponds to variant rs3749002 [ dbSNP | Ensembl ].		VAR_038459
	Natural variant	2910	1	A → T. Corresponds to variant rs16853331 [ dbSNP | Ensembl ].		VAR_038460
	Natural variant	2975	1	Y → C. Corresponds to variant rs3749003 [ dbSNP | Ensembl ].		VAR_038461
	Natural variant	3022	1	I → V. Corresponds to variant rs3749004 [ dbSNP | Ensembl ].		VAR_038462
	Natural variant	3202	1	G → E. Corresponds to variant rs16853333 [ dbSNP | Ensembl ].		VAR_038463
Experimental info
	Sequence conflict	112	1	E → G in AAH18673. Ref.6
	Sequence conflict	926	1	Q → L in CAF25193. Ref.7
	Sequence conflict	926	1	Q → L in CAD38624. Ref.8
	Sequence conflict	1144	1	Q → R in CAF25193. Ref.7
	Sequence conflict	1144	1	Q → R in CAD38624. Ref.8
	Sequence conflict	2318	1	S → P in CAD91137. Ref.8
	Sequence conflict	2522	1	H → P in CAD91146. Ref.8
	Sequence conflict	2661	1	I → M in CAD91139. Ref.8
	Sequence conflict	2665	1	K → N in CAD89958. Ref.8
	Sequence conflict	2713	1	Q → R in CAD89919. Ref.8
	Sequence conflict	2967	1	S → A in CAD91141. Ref.8
	Sequence conflict	2996	1	S → P in CAD89919. Ref.8
	Sequence conflict	3013	1	T → A in CAD91154. Ref.8
	Sequence conflict	3079	1	E → G in CAD91137. Ref.8
	Sequence conflict	3121	1	I → T in CAD89958. Ref.8
	Sequence conflict	3166	1	E → G in CAD91141. Ref.8
	Sequence conflict	3259	1	M → V in CAD91139. Ref.8
	Sequence conflict	3264	1	S → L in CAD91141. Ref.8
	Sequence conflict	3329	1	T → A in CAD91146. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: F02A01BD2D621F45	FASTA	3,374	382,300
	10 20 30 40 50 60 MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC 70 80 90 100 110 120 RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG 130 140 150 160 170 180 TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE 190 200 210 220 230 240 EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKTES EYEETFKPSS VVSTSSTSCV 250 260 270 280 290 300 STSQRKETST TRYSDHSVTS STLAQINATS SGMTEEFPPP PPDVLQTSVD VTAFSQSPEL 310 320 330 340 350 360 PSPPRRLPVP KDVYSKQRNL YELNRLYKHI HPELRKNLEK DYISEVSEIV SSQMNSGSSV 370 380 390 400 410 420 SADVQQARYV FENTNDSSQK DLNSEREYLE WDEILKGEVQ SIRWIFENQP LDSINNGSPD 430 440 450 460 470 480 EGDISRGIAD QEIIAGGDVK YTTWMFETQP IDTLGAYSSD TVENAEKIPE LARGDVCTAR 490 500 510 520 530 540 WMFETRPLDS MNKMHQSQEE SAVTISKDIT GGDVKTVRYM FETQHLDQLG QLHSVDEVHL 550 560 570 580 590 600 LQLRSELKEI KGNVKRSIKC FETQPLYVIR DGSGQMLEIK TVHREDVEKG DVRTARWMFE 610 620 630 640 650 660 TQPLDTINKD ITEIKVVRGI SMEENVKGGV SKAKWLFETQ PLEKIKESEE VIIEKEKIIG 670 680 690 700 710 720 TDVSRKCWMF ETQPLDILKE VPDADSLQRE EIIGGDVQTT KHLFETLPIE ALKDSPDIGK 730 740 750 760 770 780 LQKITASEEE KGDVRHQKWI FETQPLEDIR KDKKEYTRTV KLEEVDRGDV KNYTHIFESN 790 800 810 820 830 840 NLIKFDASHK IEVEGVTRGA VELNKSLFET TPLYAIQDPL GKYHQVKTVQ QEEIVRGDVR 850 860 870 880 890 900 SCRWLFETRP IDQFDESIHK FQIIRGISAQ EIQTGNVKSA KWLFETQPLD SIKYFSDVEE 910 920 930 940 950 960 TESKTEQTRD IVKGDVKTCK WLFETQPMES LYEKVSLMTS SEEIHKGDVK TCTWLFETQP 970 980 990 1000 1010 1020 LDTIKDDSET AVKLQTVKQE EIQGGDVRTA CFLFETENLD SIQGEEVKEI KPVEMDIQAG 1030 1040 1050 1060 1070 1080 DVSSMRYKFE NQSLDSISSS SEEVLKKIKT LKTEDIQKGN VLNCRWLFEN QPIDKIKESQ 1090 1100 1110 1120 1130 1140 EGDECVKTVT DIQGGDVRKG CFIFETFSLD EIKEESDYIS TKKTITEEVI QGDVKSYRML 1150 1160 1170 1180 1190 1200 FETQPLYAIQ DREGSYHEVT TVKKEEVIHG DVRGTRWLFE TKPLDSINKS ETVYVIKSVT 1210 1220 1230 1240 1250 1260 QEDIQKGDVS SVRYRFETQP LDQISEESHN IMPSIDHIQG GNVKTSRQFF ESENFDKNNY 1270 1280 1290 1300 1310 1320 IRTVSVNEIQ KGNVKTSTWL FETHTMDELR GEGLEYENIK TVTQEDVQKG DVKQAVWLFE 1330 1340 1350 1360 1370 1380 NRTFDSIMEA HKGITKMTKE EIPPSDVKTT TWLFETTPLH EFNETRVEKI EIIGKSIKET 1390 1400 1410 1420 1430 1440 LEDLYSQKVI QAPGIIIEAD EIGDVRMAKY KLMNQASPEI QKEEIIRADL RNIMVNLLSK 1450 1460 1470 1480 1490 1500 RDCTEREILI SEEEKGNVNL TKTQLLNRST EFHAEKEEIV KGDVQQAIKN LFSEERSVKK 1510 1520 1530 1540 1550 1560 GILIQEDEKG DINMTIYCLL HENDGDTIER EEVIGGDVKR TIHNLLSSTS NNKISERAKI 1570 1580 1590 1600 1610 1620 DASERGNVQF FTTCIEAGAL DYLKQLHTES NETLTAKKQE GEKEIIGGDV EGTKLLLKKR 1630 1640 1650 1660 1670 1680 QSLVERTVSE TDIIPGDVHN TVKVFMTEPQ STFGKIPKEE IIKGDLTSTL NSLSQAVNQK 1690 1700 1710 1720 1730 1740 TVTKTEEIIK GNMLATLKSL KESSHRWKES KQPDAIPGDI EKAIECLEKA TNTKTEILKK 1750 1760 1770 1780 1790 1800 ELLKDDLETS LRSLKEAQRS FKEVHKEGVI KKDAKAVMAG SSGEQKTDIH QVAVQRNKNS 1810 1820 1830 1840 1850 1860 LLQPKPGPFE PAAKWQGGAD TLSQTMGKSC HGNLVEERTE VNLPKAPKGT VKIVIDREQN 1870 1880 1890 1900 1910 1920 NDALEKSLRR LSNSHHKSNV LESGDKTGVW TDTTGEQHLR DEYMSRQLTS TVSVKNNLTT 1930 1940 1950 1960 1970 1980 KESDRAVREL KKDDVFNSIQ SAGKTVGKQQ TYELRNDHQK MEGFHIKSPK KTKNIKILTD 1990 2000 2010 2020 2030 2040 TQSSKPSPTQ HPVSMPVGGT YDLSGDFQKQ TLLKQETKYS NKDIKKKNIN LQPMWQLLPV 2050 2060 2070 2080 2090 2100 EQDTSNVTEM KVSEKSHNTF KATNKKRETD VHLKSQDFLM KTNTSTGLKM AMERSLNPIN 2110 2120 2130 2140 2150 2160 FNPENNVKES ECPLPPPSPP PPPPSNASSE IEFPLPPPPP LMMFPEKNGF LPSLSTEKIK 2170 2180 2190 2200 2210 2220 AEFESFPGLP LPPPPVDEKS ERESSSMFLP PPPPPTPSQK PAHLLSSSAP EKHSGDFMQQ 2230 2240 2250 2260 2270 2280 YSQKEASNSQ NSQAKIITGK TGVLPPPTLP KPKLPKHIKD NKNDFSPKVE LATSLSDMEC 2290 2300 2310 2320 2330 2340 KITTSKDQKK VMVMTSSEHT ETKQNVISKS LDERKQLSID SANCLSHTVP GTSAPRKKQI 2350 2360 2370 2380 2390 2400 APLIKSHSFP ESSGQQNPKP YMRKFKTPLM IAEEKYRQQK EEIEKQKQES SYYNIVKTQS 2410 2420 2430 2440 2450 2460 QNQHITEVEK EMPLQKTNEE VSLSGIDSEC TVVQPSPGSQ SNARILGVCS DNQLSTTSPE 2470 2480 2490 2500 2510 2520 TVAAKRLHHV LAASEDKDKM KKEVLQSSRD IMQSKSACEI KQSHQECSTQ QTQQKKYLEQ 2530 2540 2550 2560 2570 2580 LHLPQSKPIS PNFKVKTIKL PTLDHTLNET DHSYESHKQQ SEIDVQTFTK KQYLKTKKTE 2590 2600 2610 2620 2630 2640 ASTECSHKQS LAERHYQLPK KEKRVTVQLP TESIQKNQED KLKMVPRKQR EFSGSDRGKL 2650 2660 2670 2680 2690 2700 PGSEEKNQGP SMIGRKEERL ITERKHEHLK NKSAPKVVKQ KVIDAHLDSQ TQNFQQTQIQ 2710 2720 2730 2740 2750 2760 TAESKAEHKK LPQPYNSLQE EKCLEVKGIQ EKQVFSNTKD SKQEITQNKS FFSSVKESQR 2770 2780 2790 2800 2810 2820 DDGKGALNIV EFLRKREELQ QILSRVKQFE AEPNKSGLKT FQTLLNTIPG WLISEDKREY 2830 2840 2850 2860 2870 2880 AVHIAMENNL EKVKEEITHI KTQAEDMLVS YENIIQTAMM SSKTGKPGNK PTSLDETSSK 2890 2900 2910 2920 2930 2940 VSNVHVSNNK NSEQKENKIA KEKTVQHQVA AHHEATVRSH VKTHQEIKLD DSNIPPPSLK 2950 2960 2970 2980 2990 3000 TRPPSPTFIT IESTARRTEN PTKNELSQSP KKDSYVEPPP RRPMSQKSEI HRANTSPSPP 3010 3020 3030 3040 3050 3060 RSRSEQLVRL KDTTAKLSKG AIPCPAATPV PIVEKRSEII MSPATLRRQI KIETRGRDSP 3070 3080 3090 3100 3110 3120 PTITIPVNIN HAASGSFRES VDAQEEIRKV EKRATYVHKD GLNSTDHMVP DTESYDAVEI 3130 3140 3150 3160 3170 3180 IRKVAVPPRL SEHTQRYEAA NRTVQMAENF VNDPENEINR WFREFEHGPV SEAKSNRRVY 3190 3200 3210 3220 3230 3240 AKGETNHNIQ QESRTFCKEE FGLTSLGNTS FTDFSCKHPR ELREKIPVKQ PRICSETRSL 3250 3260 3270 3280 3290 3300 SEHFSGMDAF ESQIVESKMK TSSSHSSEAG KSGCDFKHAP PTYEDVIAGH ILDISDSPKE 3310 3320 3330 3340 3350 3360 VRKNFQKTWQ ESGRVFKGLG YATADASATE MRTTFQEESA FISEAAAPRQ GNMYTLSKDS 3370 LSNGVPSGRQ AEFS
	Isoform 2 [UniParc]. Checksum: DAC9F3BDE6D3EDE9	FASTA	3,327	377,347
	10 20 30 40 50 60 MARYQAAVSR GDCRSFSANM MEESEMCAVP GGLAKVKKQF EDEITSSRNT FAQYQYQHQN 70 80 90 100 110 120 RSEQEAIHSS QVGTSRSSQE MARNEQEGSK VQKIDVHGTE MVSHLEKHTE EVNQASQFHQ 130 140 150 160 170 180 YVQETVIDTP EDEEIPKVST KLLKEQFEKS AQEKILYSDK EMTTPAKQIK TESEYEETFK 190 200 210 220 230 240 PSSVVSTSST SCVSTSQRKE TSTTRYSDHS VTSSTLAQIN ATSSGMTEEF PPPPPDVLQT 250 260 270 280 290 300 SVDVTAFSQS PELPSPPRRL PVPKDVYSKQ RNLYELNRLY KHIHPELRKN LEKDYISEVS 310 320 330 340 350 360 EIVSSQMNSG SSVSADVQQA RYVFENTNDS SQKDLNSERE YLEWDEILKG EVQSIRWIFE 370 380 390 400 410 420 NQPLDSINNG SPDEGDISRG IADQEIIAGG DVKYTTWMFE TQPIDTLGAY SSDTVENAEK 430 440 450 460 470 480 IPELARGDVC TARWMFETRP LDSMNKMHQS QEESAVTISK DITGGDVKTV RYMFETQHLD 490 500 510 520 530 540 QLGQLHSVDE VHLLQLRSEL KEIKGNVKRS IKCFETQPLY VIRDGSGQML EIKTVHREDV 550 560 570 580 590 600 EKGDVRTARW MFETQPLDTI NKDITEIKVV RGISMEENVK GGVSKAKWLF ETQPLEKIKE 610 620 630 640 650 660 SEEVIIEKEK IIGTDVSRKC WMFETQPLDI LKEVPDADSL QREEIIGGDV QTTKHLFETL 670 680 690 700 710 720 PIEALKDSPD IGKLQKITAS EEEKGDVRHQ KWIFETQPLE DIRKDKKEYT RTVKLEEVDR 730 740 750 760 770 780 GDVKNYTHIF ESNNLIKFDA SHKIEVEGVT RGAVELNKSL FETTPLYAIQ DPLGKYHQVK 790 800 810 820 830 840 TVQQEEIVRG DVRSCRWLFE TRPIDQFDES IHKFQIIRGI SAQEIQTGNV KSAKWLFETQ 850 860 870 880 890 900 PLDSIKYFSD VEETESKTEQ TRDIVKGDVK TCKWLFETQP MESLYEKVSL MTSSEEIHKG 910 920 930 940 950 960 DVKTCTWLFE TQPLDTIKDD SETAVKLQTV KQEEIQGGDV RTACFLFETE NLDSIQGEEV 970 980 990 1000 1010 1020 KEIKPVEMDI QAGDVSSMRY KFENQSLDSI SSSSEEVLKK IKTLKTEDIQ KGNVLNCRWL 1030 1040 1050 1060 1070 1080 FENQPIDKIK ESQEGDECVK TVTDIQGGDV RKGCFIFETF SLDEIKEESD YISTKKTITE 1090 1100 1110 1120 1130 1140 EVIQGDVKSY RMLFETQPLY AIQDREGSYH EVTTVKKEEV IHGDVRGTRW LFETKPLDSI 1150 1160 1170 1180 1190 1200 NKSETVYVIK SVTQEDIQKG DVSSVRYRFE TQPLDQISEE SHNIMPSIDH IQGGNVKTSR 1210 1220 1230 1240 1250 1260 QFFESENFDK NNYIRTVSVN EIQKGNVKTS TWLFETHTMD ELRGEGLEYE NIKTVTQEDV 1270 1280 1290 1300 1310 1320 QKGDVKQAVW LFENRTFDSI MEAHKGITKM TKEEIPPSDV KTTTWLFETT PLHEFNETRV 1330 1340 1350 1360 1370 1380 EKIEIIGKSI KETLEDLYSQ KVIQAPGIII EADEIGDVRM AKYKLMNQAS PEIQKEEIIR 1390 1400 1410 1420 1430 1440 ADLRNIMVNL LSKRDCTERE ILISEEEKGN VNLTKTQLLN RSTEFHAEKE EIVKGDVQQA 1450 1460 1470 1480 1490 1500 IKNLFSEERS VKKGILIQED EKGDINMTIY CLLHENDGDT IEREEVIGGD VKRTIHNLLS 1510 1520 1530 1540 1550 1560 STSNNKISER AKIDASERGN VQFFTTCIEA GALDYLKQLH TESNETLTAK KQEGEKEIIG 1570 1580 1590 1600 1610 1620 GDVEGTKLLL KKRQSLVERT VSETDIIPGD VHNTVKVFMT EPQSTFGKIP KEEIIKGDLT 1630 1640 1650 1660 1670 1680 STLNSLSQAV NQKTVTKTEE IIKGNMLATL KSLKESSHRW KESKQPDAIP GDIEKAIECL 1690 1700 1710 1720 1730 1740 EKATNTKTEI LKKELLKDDL ETSLRSLKEA QRSFKEVHKE GVIKKDAKAV MAGSSGEQKT 1750 1760 1770 1780 1790 1800 DIHQVAVQRN KNSLLQPKPG PFEPAAKWQG GADTLSQTMG KSCHGNLVEE RTEVNLPKAP 1810 1820 1830 1840 1850 1860 KGTVKIVIDR EQNNDALEKS LRRLSNSHHK SNVLESGDKT GVWTDTTGEQ HLRDEYMSRQ 1870 1880 1890 1900 1910 1920 LTSTVSVKNN LTTKESDRAV RELKKDDVFN SIQSAGKTVG KQQTYELRND HQKMEGFHIK 1930 1940 1950 1960 1970 1980 SPKKTKNIKI LTDTQSSKPS PTQHPVSMPV GGTYDLSGDF QKQTLLKQET KYSNKDIKKK 1990 2000 2010 2020 2030 2040 NINLQPMWQL LPVEQDTSNV TEMKVSEKSH NTFKATNKKR ETDVHLKSQD FLMKTNTSTG 2050 2060 2070 2080 2090 2100 LKMAMERSLN PINFNPENNV KESECPLPPP SPPPPPPSNA SSEIEFPLPP PPPLMMFPEK 2110 2120 2130 2140 2150 2160 NGFLPSLSTE KIKAEFESFP GLPLPPPPVD EKSERESSSM FLPPPPPPTP SQKPAHLLSS 2170 2180 2190 2200 2210 2220 SAPEKHSGDF MQQYSQKEAS NSQNSQAKII TGKTGVLPPP TLPKPKLPKH IKDNKNDFSP 2230 2240 2250 2260 2270 2280 KVELATSLSD MECKITTSKD QKKVMVMTSS EHTETKQNVI SKSLDERKQL SIDSANCLSH 2290 2300 2310 2320 2330 2340 TVPGTSAPRK KQIAPLIKSH SFPESSGQQN PKPYMRKFKT PLMIAEEKYR QQKEEIEKQK 2350 2360 2370 2380 2390 2400 QESSYYNIVK TQSQNQHITE VEKEMPLQKT NEEVSLSGID SECTVVQPSP GSQSNARILG 2410 2420 2430 2440 2450 2460 VCSDNQLSTT SPETVAAKRL HHVLAASEDK DKMKKEVLQS SRDIMQSKSA CEIKQSHQEC 2470 2480 2490 2500 2510 2520 STQQTQQKKY LEQLHLPQSK PISPNFKVKT IKLPTLDHTL NETDHSYESH KQQSEIDVQT 2530 2540 2550 2560 2570 2580 FTKKQYLKTK KTEASTECSH KQSLAERHYQ LPKKEKRVTV QLPTESIQKN QEDKLKMVPR 2590 2600 2610 2620 2630 2640 KQREFSGSDR GKLPGSEEKN QGPSMIGRKE ERLITERKHE HLKNKSAPKV VKQKVIDAHL 2650 2660 2670 2680 2690 2700 DSQTQNFQQT QIQTAESKAE HKKLPQPYNS LQEEKCLEVK GIQEKQVFSN TKDSKQEITQ 2710 2720 2730 2740 2750 2760 NKSFFSSVKE SQRDDGKGAL NIVEFLRKRE ELQQILSRVK QFEAEPNKSG LKTFQTLLNT 2770 2780 2790 2800 2810 2820 IPGWLISEDK REYAVHIAME NNLEKVKEEI THIKTQAEDM LVSYENIIQT AMMSSKTGKP 2830 2840 2850 2860 2870 2880 GNKPTSLDET SSKVSNVHVS NNKNSEQKEN KIAKEKTVQH QVAAHHEATV RSHVKTHQEI 2890 2900 2910 2920 2930 2940 KLDDSNIPPP SLKTRPPSPT FITIESTARR TENPTKNELS QSPKKDSYVE PPPRRPMSQK 2950 2960 2970 2980 2990 3000 SEIHRANTSP SPPRSRSEQL VRLKDTTAKL SKGAIPCPAA TPVPIVEKRS EIIMSPATLR 3010 3020 3030 3040 3050 3060 RQIKIETRGR DSPPTITIPV NINHAASGSF RESVDAQEEI RKVEKRATYV HKDGLNSTDH 3070 3080 3090 3100 3110 3120 MVPDTESYDA VEIIRKVAVP PRLSEHTQRY EAANRTVQMA ENFVNDPENE INRWFREFEH 3130 3140 3150 3160 3170 3180 GPVSEAKSNR RVYAKGETNH NIQQESRTFC KEEFGLTSLG NTSFTDFSCK HPRELREKIP 3190 3200 3210 3220 3230 3240 VKQPRICSET RSLSEHFSGM DAFESQIVES KMKTSSSHSS EAGKSGCDFK HAPPTYEDVI 3250 3260 3270 3280 3290 3300 AGHILDISDS PKEVRKNFQK TWQESGRVFK GLGYATADAS ATEMRTTFQE ESAFISEAAA 3310 3320 PRQGNMYTLS KDSLSNGVPS GRQAEFS
	Isoform 3 [UniParc]. Checksum: BA1BAC0E92843A1E	FASTA	3,345	379,233
	10 20 30 40 50 60 MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC 70 80 90 100 110 120 RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG 130 140 150 160 170 180 TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE 190 200 210 220 230 240 EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKTES EYEETFKPSS VVSTSSTSCV 250 260 270 280 290 300 STSQRKETST TRYSDHSVTS STLAQINATS SGMTEEFPPP PPDVLQTSVD VTAFSQSPEL 310 320 330 340 350 360 PSPPRRLPVP KDVYSKQRNL YELNRLYKHI HPELRKNLEK DYISEVSEIV SSQMNSGSSV 370 380 390 400 410 420 SADVQQARYV FENTNDSSQK DLNSEREYLE WDEILKGEVQ SIRWIFENQP LDSINNGSPD 430 440 450 460 470 480 EGDISRGIAD QEIIAGGDVK YTTWMFETQP IDTLGAYSSD TVENAEKIPE LARGDVCTAR 490 500 510 520 530 540 WMFETRPLDS MNKMHQSQEE SAVTISKDIT GGDVKTVRYM FETQHLDQLG QLHSVDEVHL 550 560 570 580 590 600 LQLRSELKEI KGNVKRSIKC FETQPLYVIR DGSGQMLEIK TVHREDVEKG DVRTARWMFE 610 620 630 640 650 660 TQPLDTINKD ITEIKVVRGI SMEENVKGGV SKAKWLFETQ PLEKIKESEE VIIEKEKIIG 670 680 690 700 710 720 TDVSRKCWMF ETQPLDILKE VPDADSLQRE EIIGGDVQTT KHLFETLPIE ALKDSPDIGK 730 740 750 760 770 780 LQKITASEEE KGDVRHQKWI FETQPLEDIR KDKKEYTRTV KLEEVDRGDV KNYTHIFESN 790 800 810 820 830 840 NLIKFDASHK IEVEGVTRGA VELNKSLFET TPLYAIQDPL GKYHQVKTVQ QEEIVRGDVR 850 860 870 880 890 900 SCRWLFETRP IDQFDESIHK FQIIRGISAQ EIQTGNVKSA KWLFETQPLD SIKYFSDVEE 910 920 930 940 950 960 TESKTEQTRD IVKGDVKTCK WLFETQPMES LYEKVSLMTS SEEIHKGDVK TCTWLFETQP 970 980 990 1000 1010 1020 LDTIKDDSET AVKLQTVKQE EIQGGDVRTA CFLFETENLD SIQGEEVKEI KPVEMDIQAG 1030 1040 1050 1060 1070 1080 DVSSMRYKFE NQSLDSISSS SEEVLKKIKT LKTEDIQKGN VLNCRWLFEN QPIDKIKESQ 1090 1100 1110 1120 1130 1140 EGDECVKTVT DIQGGDVRKG CFIFETFSLD EIKEESDYIS TKKTITEEVI QGDVKSYRML 1150 1160 1170 1180 1190 1200 FETQPLYAIQ DREGSYHEVT TVKKEEVIHG DVRGTRWLFE TKPLDSINKS ETVYVIKSVT 1210 1220 1230 1240 1250 1260 QEDIQKGDVS SVRYRFETQP LDQISEESHN IMPSIDHIQG GNVKTSRQFF ESENFDKNNY 1270 1280 1290 1300 1310 1320 IRTVSVNEIQ KGNVKTSTWL FETHTMDELR GEGLEYENIK TVTQEDVQKG DVKQAVWLFE 1330 1340 1350 1360 1370 1380 NRTFDSIMEA HKGITKMTKE EIPPSDVKTT TWLFETTPLH EFNETRVEKI EIIGKSIKET 1390 1400 1410 1420 1430 1440 LEDLYSQKVI QAPGIIIEAD EIGDVRMAKY KLMNQASPEI QKEEIIRADL RNIMVNLLSK 1450 1460 1470 1480 1490 1500 RDCTEREILI SEEEKGNVNL TKTQLLNRST EFHAEKEEIV KGDVQQAIKN LFSEERSVKK 1510 1520 1530 1540 1550 1560 GILIQEDEKG DINMTIYCLL HENDGDTIER EEVIGGDVKR TIHNLLSSTS NNKISERAKI 1570 1580 1590 1600 1610 1620 DASERGNVQF FTTCIEAGAL DYLKQLHTES NETLTAKKQE GEKEIIGGDV EGTKLLLKKR 1630 1640 1650 1660 1670 1680 QSLVERTVSE TDIIPGDVHN TVKVFMTEPQ STFGKIPKEE IIKGDLTSTL NSLSQAVNQK 1690 1700 1710 1720 1730 1740 TVTKTEEIIK GNMLATLKSL KESSHRWKES KQPDAIPGDI EKAIECLEKA TNTKTEILKK 1750 1760 1770 1780 1790 1800 ELLKDDLETS LRSLKEAQRS FKEVHKEGVI KKDAKAVMAG SSGEQKTDIH QVAVQRNKNS 1810 1820 1830 1840 1850 1860 LLQPKPGPFE PAAKWQGGAD TLSQTMGKSC HGNLVEERTE VNLPKAPKGT VKIVIDREQN 1870 1880 1890 1900 1910 1920 NDALEKSLRR LSNSHHKSNV LESGDKTGVW TDTTGEQHLR DEYMSRQLTS TVSVKNNLTT 1930 1940 1950 1960 1970 1980 KESDRAVREL KKDDVFNSIQ SAGKTVGKQQ TYELRNDHQK MEGFHIKSPK KTKNIKILTD 1990 2000 2010 2020 2030 2040 TQSSKPSPTQ HPVSMPVGGT YDLSGDFQKQ TLLKQETKYS NKDIKKKNIN LQPMWQLLPV 2050 2060 2070 2080 2090 2100 EQDTSNVTEM KVSEKSHNTF KATNKKRETD VHLKSQDFLM KTNTSTGLKM AMERSLNPIN 2110 2120 2130 2140 2150 2160 FNPENNVKES ECPLPPPSPP PPPPSNASSE IEFPLPPPPP LMMFPEKNGF LPSLSTEKIK 2170 2180 2190 2200 2210 2220 AEFESFPGLP LPPPPVDEKS ERESSSMFLP PPPPPTPSQK PAHLLSSSAP EKHSGDFMQQ 2230 2240 2250 2260 2270 2280 YSQKEASNSQ NSQAKIITGK TGVLPPPTLP KPKLPKHIKD NKNDFSPKVE LATSLSDMEC 2290 2300 2310 2320 2330 2340 KITTSKDQKK VMVMTSSEHT ETKQNVISKS LDERKQLSID SANCLSHTVP GTSAPRKKQI 2350 2360 2370 2380 2390 2400 APLIKSHSFP ESSGQQNPKP YMRKFKTPLM IAEEKYRQQK EEIEKQKQES SYYNIVKTQS 2410 2420 2430 2440 2450 2460 QNQHITEVEK EMPLQKTNEE VSLSGIDSEC TVVQPSPGSQ SNARILGVCS DNQLSTTSPE 2470 2480 2490 2500 2510 2520 TVAAKRLHHV LAASEDKDKM KKEVLQSSRD IMQSKSACEI KQSHQECSTQ QTQQKKYLEQ 2530 2540 2550 2560 2570 2580 LHLPQSKPIS PNFKVKTIKL PTLDHTLNET DHSYESHKQQ SEIDVQTFTK KQYLKTKKTE 2590 2600 2610 2620 2630 2640 ASTECSHKQS LAERHYQLPK KEKRVTVQLP TESIQKNQED KLKMVPRKQR EFSGSDRGKL 2650 2660 2670 2680 2690 2700 PGSEEKNQGP SMIGRKEERL ITERKHEHLK NKSAPKVVKQ KVIDAHLDSQ TQNFQQTQIQ 2710 2720 2730 2740 2750 2760 TAESKAEHKK LPQPYNSLQE EKCLEVKGIQ EKQVFSNTKD SKQEITQNKS FFSSVKESQR 2770 2780 2790 2800 2810 2820 DDGKGALNIV EFLRKREELQ QILSRVKQFE AEPNKSGLKT FQTLLNTIPG WLISEDKREY 2830 2840 2850 2860 2870 2880 AVHIAMENNL EKVKEEITHI KTQAEDMLVS YENIIQTAMM SSKTGKPGNK PTSLDETSSK 2890 2900 2910 2920 2930 2940 VSNVHVSNNK NSEQKENKIA KEKTVQHQVA AHHEATVRSH VKTHQEIKLD DSNIPPPSLK 2950 2960 2970 2980 2990 3000 TRPPSPTFIT IESTARRTEN PTKNELSQSP KKDSYVEPPP RRPMSQKSEI HRANTSPSPP 3010 3020 3030 3040 3050 3060 RSRSEQLVRL KDTTAKLSKG AIPCPAATPV PIVEKRSEII MSPATLRRQI KIETRGRDSP 3070 3080 3090 3100 3110 3120 PTITIPVNIN HAASGSFRES VDAQEEIRKV EKRATYVHKD GLNSTDHMVP DTESYDAVEI 3130 3140 3150 3160 3170 3180 IRKVAVPPRL SEHTQRYEAA NRTVQMAENF VNDPENEINR WFREFEHGPV SEAKSNRRVY 3190 3200 3210 3220 3230 3240 AKGETNHNIQ QESRTFCKEE FGLTSLGNTS FTDFSCKHPR ELREKIPVKQ PRICSETRSL 3250 3260 3270 3280 3290 3300 SEHFSGMDAF ESQIVESKMK TSSSHSSEAG KSGCDFKHAP PTYEDVIAGH ILDISDSPKE 3310 3320 3330 3340 VRKNFQKTWQ ESGRVFKGLG YATADASATE MRTTFQEESA FISGK
	Isoform 4 [UniParc]. Checksum: 07F5488631088491	FASTA	938	106,597
	10 20 30 40 50 60 MFPMQKGSLN LLRQKWESCD YQRSECHPRD SHCTIFQPQE SKLLAPEGEV VSAPQSLDPT 70 80 90 100 110 120 SLPYSTGEEM WSSKPEEKDS VDKSNNTREY GRPEVLKEDS LSSRRRIERF SIALDELRSV 130 140 150 160 170 180 FEAPKSGNKP AEYGGKEVEI ERSLCSPAFK SHPGSQLEDS VKDSDKKGKE TSFDKMSPES 190 200 210 220 230 240 GHSRIFEATA GPNKPESGFA EDSAARGEGV SDLHEVVSLK ERMARYQAAV SRGDCRSFSA 250 260 270 280 290 300 NMMEESEMCA VPGGLAKVKK QFEDEITSSR NTFAQYQYQH QNRSEQEAIH SSQVGTSRSS 310 320 330 340 350 360 QEMARNEQEG SKVQKIDVHG TEMVSHLEKH TEEVNQASQF HQYVQETVID TPEDEEIPKV 370 380 390 400 410 420 STKLLKEQFE KSAQEKILYS DKEMTTPAKQ IKKLLLQDKE ICILCQKTVY PMECLVADKQ 430 440 450 460 470 480 NFHKSCFRCH HCNSKLSLGN YASLHGQIYC KPHFKQLFKS KGNYDEGFGH KQHKDRWNCK 490 500 510 520 530 540 NQSRSVDFIP NEEPNMCKNI AENTLVPGDR NEHLDAGNSE GQRNDLRKLG ERGKLKVIWP 550 560 570 580 590 600 PSKEIPKKTL PFEEELKMSK PKWPPEMTTL LSPEFKSESL LEDVRTPENK GQRQDHFPFL 610 620 630 640 650 660 QPYLQSTHVC QKEDVIGIKE MKMPEGRKDE KKEGRKNVQD RPSEAEDTKS NRKSAMDLND 670 680 690 700 710 720 NNNVIVQSAE KEKNEKTNQT NGAEVLQVTN TDDEMMPENH KENLNKNNNN NYVAVSYLNN 730 740 750 760 770 780 CRQKTSILEF LDLLPLSSEA NDTANEYEIE KLENTSRISE LLGIFESEKT YSRNVLAMAL 790 800 810 820 830 840 KKQTDRAAAG SPVQPAPKPS LSRGLMVKGG SSIISPDTNL LNIKGSHSKS KNLHFFFSNT 850 860 870 880 890 900 VKITAFSKKN ENIFNCDLID SVDQIKNMPC LDLREFGKDV KPWHVETTEA ARNNENTGFD 910 920 930 ALSHECTAKP LFPRVEVQSE QLTVEEQIKR NRCYSDTE
	Isoform 5 [UniParc]. Checksum: 9C40EB72B01F0750	FASTA	763	86,782
	10 20 30 40 50 60 MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC 70 80 90 100 110 120 RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG 130 140 150 160 170 180 TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE 190 200 210 220 230 240 EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKKLL LQDKEICILC QKTVYPMECL 250 260 270 280 290 300 VADKQNFHKS CFRCHHCNSK LSLGNYASLH GQIYCKPHFK QLFKSKGNYD EGFGHKQHKD 310 320 330 340 350 360 RWNCKNQSRS VDFIPNEEPN MCKNIAENTL VPGDRNEHLD AGNSEGQRND LRKLGERGKL 370 380 390 400 410 420 KVIWPPSKEI PKKTLPFEEE LKMSKPKWPP EMTTLLSPEF KSESLLEDVR TPENKGQRQD 430 440 450 460 470 480 HFPFLQPYLQ STHVCQKEDV IGIKEMKMPE GRKDEKKEGR KNVQDRPSEA EDTKSNRKSA 490 500 510 520 530 540 MDLNDNNNVI VQSAEKEKNE KTNQTNGAEV LQVTNTDDEM MPENHKENLN KNNNNNYVAV 550 560 570 580 590 600 SYLNNCRQKT SILEFLDLLP LSSEANDTAN EYEIEKLENT SRISELLGIF ESEKTYSRNV 610 620 630 640 650 660 LAMALKKQTD RAAAGSPVQP APKPSLSRGL MVKGGSSIIS PDTNLLNIKG SHSKSKNLHF 670 680 690 700 710 720 FFSNTVKITA FSKKNENIFN CDLIDSVDQI KNMPCLDLRE FGKDVKPWHV ETTEAARNNE 730 740 750 760 NTGFDALSHE CTAKPLFPRV EVQSEQLTVE EQIKRNRCYS DTE
	Isoform 6 [UniParc]. Checksum: D7D81097B20E3582	FASTA	971	110,333
	10 20 30 40 50 60 MFPMQKGSLN LLRQKWESCD YQRSECHPRD SHCTIFQPQE SKLLAPEGEV VSAPQSLDPT 70 80 90 100 110 120 SLPYSTGEEM WSSKPEEKDS VDKSNNTREY GRPEVLKEDS LSSRRRIERF SIALDELRSV 130 140 150 160 170 180 FEAPKSGNKP AEYGGKEVEI ERSLCSPAFK SHPGSQLEDS VKDSDKKGKE TSFDKMSPES 190 200 210 220 230 240 GHSRIFEAVF STDQAQILRL HLHPKLTKTP KNSLKSSTYI STAGPNKPES GFAEDSAARG 250 260 270 280 290 300 EGVSDLHEVV SLKERMARYQ AAVSRGDCRS FSANMMEESE MCAVPGGLAK VKKQFEDEIT 310 320 330 340 350 360 SSRNTFAQYQ YQHQNRSEQE AIHSSQVGTS RSSQEMARNE QEGSKVQKID VHGTEMVSHL 370 380 390 400 410 420 EKHTEEVNQA SQFHQYVQET VIDTPEDEEI PKVSTKLLKE QFEKSAQEKI LYSDKEMTTP 430 440 450 460 470 480 AKQIKKLLLQ DKEICILCQK TVYPMECLVA DKQNFHKSCF RCHHCNSKLS LGNYASLHGQ 490 500 510 520 530 540 IYCKPHFKQL FKSKGNYDEG FGHKQHKDRW NCKNQSRSVD FIPNEEPNMC KNIAENTLVP 550 560 570 580 590 600 GDRNEHLDAG NSEGQRNDLR KLGERGKLKV IWPPSKEIPK KTLPFEEELK MSKPKWPPEM 610 620 630 640 650 660 TTLLSPEFKS ESLLEDVRTP ENKGQRQDHF PFLQPYLQST HVCQKEDVIG IKEMKMPEGR 670 680 690 700 710 720 KDEKKEGRKN VQDRPSEAED TKSNRKSAMD LNDNNNVIVQ SAEKEKNEKT NQTNGAEVLQ 730 740 750 760 770 780 VTNTDDEMMP ENHKENLNKN NNNNYVAVSY LNNCRQKTSI LEFLDLLPLS SEANDTANEY 790 800 810 820 830 840 EIEKLENTSR ISELLGIFES EKTYSRNVLA MALKKQTDRA AAGSPVQPAP KPSLSRGLMV 850 860 870 880 890 900 KGGSSIISPD TNLLNIKGSH SKSKNLHFFF SNTVKITAFS KKNENIFNCD LIDSVDQIKN 910 920 930 940 950 960 MPCLDLREFG KDVKPWHVET TEAARNNENT GFDALSHECT AKPLFPRVEV QSEQLTVEEQ 970 IKRNRCYSDT E
	Isoform 7 [UniParc]. Checksum: 88B0CF8F625388C8	FASTA	716	81,830
	10 20 30 40 50 60 MARYQAAVSR GDCRSFSANM MEESEMCAVP GGLAKVKKQF EDEITSSRNT FAQYQYQHQN 70 80 90 100 110 120 RSEQEAIHSS QVGTSRSSQE MARNEQEGSK VQKIDVHGTE MVSHLEKHTE EVNQASQFHQ 130 140 150 160 170 180 YVQETVIDTP EDEEIPKVST KLLKEQFEKS AQEKILYSDK EMTTPAKQIK KLLLQDKEIC 190 200 210 220 230 240 ILCQKTVYPM ECLVADKQNF HKSCFRCHHC NSKLSLGNYA SLHGQIYCKP HFKQLFKSKG 250 260 270 280 290 300 NYDEGFGHKQ HKDRWNCKNQ SRSVDFIPNE EPNMCKNIAE NTLVPGDRNE HLDAGNSEGQ 310 320 330 340 350 360 RNDLRKLGER GKLKVIWPPS KEIPKKTLPF EEELKMSKPK WPPEMTTLLS PEFKSESLLE 370 380 390 400 410 420 DVRTPENKGQ RQDHFPFLQP YLQSTHVCQK EDVIGIKEMK MPEGRKDEKK EGRKNVQDRP 430 440 450 460 470 480 SEAEDTKSNR KSAMDLNDNN NVIVQSAEKE KNEKTNQTNG AEVLQVTNTD DEMMPENHKE 490 500 510 520 530 540 NLNKNNNNNY VAVSYLNNCR QKTSILEFLD LLPLSSEAND TANEYEIEKL ENTSRISELL 550 560 570 580 590 600 GIFESEKTYS RNVLAMALKK QTDRAAAGSP VQPAPKPSLS RGLMVKGGSS IISPDTNLLN 610 620 630 640 650 660 IKGSHSKSKN LHFFFSNTVK ITAFSKKNEN IFNCDLIDSV DQIKNMPCLD LREFGKDVKP 670 680 690 700 710 WHVETTEAAR NNENTGFDAL SHECTAKPLF PRVEVQSEQL TVEEQIKRNR CYSDTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene containing a Xin repeat." Luo J., Liu M., Wu X. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"bXin: genes, splice variants and cellular distribution of a family of proteins implicated." Wang K., Xie L., Tsai W.L., Gutierrez-Cruz G. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 6 AND 7). Tissue: Heart and Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 901-1683 (ISOFORMS 1/2/3). Tissue: Tongue.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-748 (ISOFORMS 1/2/3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3177-3374 (ISOFORMS 1/2). Tissue: Skeletal muscle.
[7]	"Xin repeats define a novel actin-binding motif." Pacholsky D., Vakeel P., Himmel M., Loewe T., Stradal T., Rottner K., Fuerst D.O., van der Ven P.F.M. J. Cell Sci. 117:5257-5268(2004) [PubMed: 15454575] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 361-1380 (ISOFORMS 1/2/3), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH F-ACTIN. Tissue: Skeletal muscle.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-3374 (ISOFORMS 1/2). Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY820969 mRNA. Translation: AAV87913.1. EF119717 mRNA. Translation: ABO69245.1. EF119718 mRNA. Translation: ABO69246.1. EF119719 mRNA. Translation: ABO69247.1. EF119720 mRNA. Translation: ABO69248.1. EF119721 mRNA. Translation: ABO69249.1. EF119722 mRNA. Translation: ABO69250.1. EF119711 mRNA. Translation: ABO69251.1. AK096430 mRNA. No translation available. AK122889 mRNA. Translation: BAG53782.1. AC093684 Genomic DNA. Translation: AAY24138.1. Sequence problems. AC108494 Genomic DNA. No translation available. AC133782 Genomic DNA. No translation available. AC092601 Genomic DNA. No translation available. CH471058 Genomic DNA. Translation: EAX11311.1. BC018673 mRNA. Translation: AAH18673.1. Sequence problems. BC022888 mRNA. No translation available. AJ626901 mRNA. Translation: CAF25193.1. AL832331 mRNA. Translation: CAD38624.1. Sequence problems. AL831970 mRNA. Translation: CAD89919.1. AL832452 mRNA. Translation: CAD89958.1. Sequence problems. AL832336 mRNA. Translation: CAD91137.1. AL831985 mRNA. Translation: CAD91139.1. AL833291 mRNA. Translation: CAD91141.2. Sequence problems. AL832011 mRNA. Translation: CAD91146.1. AL832360 mRNA. Translation: CAD91154.1. AL832382 mRNA. Translation: CAD91156.1.
IPI	IPI00167400. IPI00550232. IPI00885004. IPI00893002. IPI00915318. IPI00915341. IPI01015807.
RefSeq	NP_001073278.1. NM_001079810.3. NP_001186072.1. NM_001199143.1. NP_001186073.1. NM_001199144.1. NP_001186074.1. NM_001199145.1. NP_689594.4. NM_152381.5.
UniGene	Hs.73680.
3D structure databases
ProteinModelPortal	A4UGR9.
ModBase	Search...
Protein-protein interaction databases
IntAct	A4UGR9. 1 interaction.
STRING	A4UGR9.
PTM databases
PhosphoSite	A4UGR9.
Proteomic databases
PRIDE	A4UGR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295237; ENSP00000295237; ENSG00000163092. ENST00000409195; ENSP00000386840; ENSG00000163092. ENST00000413534; ENSP00000393625; ENSG00000163092.
GeneID	129446.
KEGG	hsa:129446.
UCSC	uc002udx.1. human. uc002udy.2. human.
Organism-specific databases
CTD	129446.
GeneCards	GC02P167744.
H-InvDB	HIX0002564.
HGNC	HGNC:14303. XIRP2.
HPA	HPA034813.
MIM	609778. gene.
neXtProt	NX_A4UGR9.
PharmGKB	PA162409337.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06833.
GeneTree	ENSGT00530000063779.
HOVERGEN	HBG108682.
InParanoid	A4UGR9.
Gene expression databases
Bgee	A4UGR9.
Genevestigator	A4UGR9.
Family and domain databases
InterPro	IPR012510. Actin-binding_Xin_repeat. [Graphical view]
Pfam	PF08043. Xin. 14 hits. [Graphical view]
PROSITE	PS51389. XIN. 28 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	82581.
SOURCE	Search...

Entry information

Entry name

XIRP2_HUMAN

Accession

Primary (citable) accession number: A4UGR9
Secondary accession number(s): A0PJ94 , B2BBS0, B2BBS1, B2BBS4, B3KVH0, Q53R52, Q5MJ67, Q702N7, Q86T36, Q86T38, Q86T46, Q86T51, Q86T53, Q86T55, Q86T79, Q86TB6, Q8N1M9, Q8N3R5, Q8TBV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.