Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A4UBV5

- KYNU_MAGO7

UniProt

A4UBV5 - KYNU_MAGO7

Protein

Kynureninase

Gene

BNA5

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei166 – 1661Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei167 – 1671Pyridoxal phosphateUniRule annotation
    Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation
    Binding sitei281 – 2811Pyridoxal phosphateUniRule annotation
    Binding sitei303 – 3031Pyridoxal phosphateUniRule annotation
    Binding sitei337 – 3371Pyridoxal phosphateUniRule annotation
    Binding sitei365 – 3651Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. mycelium development Source: PAMGO_MGG
    5. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    6. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 5UniRule annotation
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:BNA5UniRule annotation
    ORF Names:MGG_10969
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 5

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497KynureninasePRO_0000360870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei304 – 3041N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi148305.A4UBV5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 1974Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    KOiK01556.
    OrthoDBiEOG7V1G0J.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4UBV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATQKSLCA IPADPIEFPA DANTLDYARS EDAKCPIRHM REHFIFPTRA    50
    SLKKKALDGR LPAYPPNHAK PGETATAQNG TSNTNDDNVT PAVYFCGNSL 100
    GLQPKATRDH INAQLETWAS IGVHGHFTSW DNSPLKSWQD MAADCAAQSA 150
    SVVGASPDEI AIMNTLTANL HFMMASFYRP TEKRHKIISE WKPFPSDTYA 200
    IASQIQWHGF DTATSLVELH PDENYYISTE KILATIDEHA ESTALLLLPG 250
    IQYWSGQLFD MPLITAHARA KGIVVGWDLA HAVGNVPLSL HDWDVDFAIW 300
    CTYKYLNAGP GAIAGAFVHE RHGKVDSDGF KLRLSGWYGN NKATRFNMAK 350
    DFDPTPGAQG WVVSNPSGID LASLGAALSV YNLTTPADLR KKSLWLTAYA 400
    EHLLNGILKD EAASSAGDGK KPAFRIITPS NKNERGAQLS VLLREGLLDV 450
    VGEKMEAAGV VCDRRKPDVM RVAPVPMYNS YEDVWRCVDA LRKAVMS 497
    Length:497
    Mass (Da):54,479
    Last modified:January 25, 2012 - v2
    Checksum:iF15D53786575CFDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48171.1.
    CM001235 Genomic DNA. Translation: EHA48172.1.
    RefSeqiXP_003717755.1. XM_003717707.1.
    XP_003717756.1. XM_003717708.1.

    Genome annotation databases

    EnsemblFungiiMGG_10969T0; MGG_10969T0; MGG_10969.
    MGG_10969T1; MGG_10969T1; MGG_10969.
    GeneIDi2677723.
    KEGGimgr:MGG_10969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001235 Genomic DNA. Translation: EHA48171.1 .
    CM001235 Genomic DNA. Translation: EHA48172.1 .
    RefSeqi XP_003717755.1. XM_003717707.1.
    XP_003717756.1. XM_003717708.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 148305.A4UBV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_10969T0 ; MGG_10969T0 ; MGG_10969 .
    MGG_10969T1 ; MGG_10969T1 ; MGG_10969 .
    GeneIDi 2677723.
    KEGGi mgr:MGG_10969.

    Phylogenomic databases

    eggNOGi COG3844.
    KOi K01556.
    OrthoDBi EOG7V1G0J.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

    Entry informationi

    Entry nameiKYNU_MAGO7
    AccessioniPrimary (citable) accession number: A4UBV5
    Secondary accession number(s): G4NBX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3