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A4UBV5

- KYNU_MAGO7

UniProt

A4UBV5 - KYNU_MAGO7

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Protein

Kynureninase

Gene

BNA5

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei167 – 1671Pyridoxal phosphateUniRule annotation
Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation
Binding sitei281 – 2811Pyridoxal phosphateUniRule annotation
Binding sitei303 – 3031Pyridoxal phosphateUniRule annotation
Binding sitei337 – 3371Pyridoxal phosphateUniRule annotation
Binding sitei365 – 3651Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. mycelium development Source: PAMGO_MGG
  5. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  6. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:MGG_10969
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497KynureninasePRO_0000360870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi148305.A4UBV5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 1974Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
InParanoidiA4UBV5.
KOiK01556.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4UBV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATQKSLCA IPADPIEFPA DANTLDYARS EDAKCPIRHM REHFIFPTRA
60 70 80 90 100
SLKKKALDGR LPAYPPNHAK PGETATAQNG TSNTNDDNVT PAVYFCGNSL
110 120 130 140 150
GLQPKATRDH INAQLETWAS IGVHGHFTSW DNSPLKSWQD MAADCAAQSA
160 170 180 190 200
SVVGASPDEI AIMNTLTANL HFMMASFYRP TEKRHKIISE WKPFPSDTYA
210 220 230 240 250
IASQIQWHGF DTATSLVELH PDENYYISTE KILATIDEHA ESTALLLLPG
260 270 280 290 300
IQYWSGQLFD MPLITAHARA KGIVVGWDLA HAVGNVPLSL HDWDVDFAIW
310 320 330 340 350
CTYKYLNAGP GAIAGAFVHE RHGKVDSDGF KLRLSGWYGN NKATRFNMAK
360 370 380 390 400
DFDPTPGAQG WVVSNPSGID LASLGAALSV YNLTTPADLR KKSLWLTAYA
410 420 430 440 450
EHLLNGILKD EAASSAGDGK KPAFRIITPS NKNERGAQLS VLLREGLLDV
460 470 480 490
VGEKMEAAGV VCDRRKPDVM RVAPVPMYNS YEDVWRCVDA LRKAVMS
Length:497
Mass (Da):54,479
Last modified:January 25, 2012 - v2
Checksum:iF15D53786575CFDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA48171.1.
CM001235 Genomic DNA. Translation: EHA48172.1.
RefSeqiXP_003717755.1. XM_003717707.1.
XP_003717756.1. XM_003717708.1.

Genome annotation databases

EnsemblFungiiMGG_10969T0; MGG_10969T0; MGG_10969.
MGG_10969T1; MGG_10969T1; MGG_10969.
GeneIDi2677723.
KEGGimgr:MGG_10969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA48171.1 .
CM001235 Genomic DNA. Translation: EHA48172.1 .
RefSeqi XP_003717755.1. XM_003717707.1.
XP_003717756.1. XM_003717708.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 148305.A4UBV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_10969T0 ; MGG_10969T0 ; MGG_10969 .
MGG_10969T1 ; MGG_10969T1 ; MGG_10969 .
GeneIDi 2677723.
KEGGi mgr:MGG_10969.

Phylogenomic databases

eggNOGi COG3844.
InParanoidi A4UBV5.
KOi K01556.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiKYNU_MAGO7
AccessioniPrimary (citable) accession number: A4UBV5
Secondary accession number(s): G4NBX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 25, 2012
Last modified: November 26, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3