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Protein

Kynureninase

Gene

BNA5

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (BNA5)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei167Pyridoxal phosphateUniRule annotation1
Binding sitei278Pyridoxal phosphateUniRule annotation1
Binding sitei281Pyridoxal phosphateUniRule annotation1
Binding sitei303Pyridoxal phosphateUniRule annotation1
Binding sitei337Pyridoxal phosphateUniRule annotation1
Binding sitei365Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:MGG_10969
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
Proteomesi
  • UP000009058 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:MGG_10969

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003608701 – 497KynureninaseAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA4UBV5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi318829.MGG_10969T0

Structurei

3D structure databases

SMRiA4UBV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 197Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

InParanoidiA4UBV5
KOiK01556
OrthoDBiEOG092C20ON

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 3 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

A4UBV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATQKSLCA IPADPIEFPA DANTLDYARS EDAKCPIRHM REHFIFPTRA
60 70 80 90 100
SLKKKALDGR LPAYPPNHAK PGETATAQNG TSNTNDDNVT PAVYFCGNSL
110 120 130 140 150
GLQPKATRDH INAQLETWAS IGVHGHFTSW DNSPLKSWQD MAADCAAQSA
160 170 180 190 200
SVVGASPDEI AIMNTLTANL HFMMASFYRP TEKRHKIISE WKPFPSDTYA
210 220 230 240 250
IASQIQWHGF DTATSLVELH PDENYYISTE KILATIDEHA ESTALLLLPG
260 270 280 290 300
IQYWSGQLFD MPLITAHARA KGIVVGWDLA HAVGNVPLSL HDWDVDFAIW
310 320 330 340 350
CTYKYLNAGP GAIAGAFVHE RHGKVDSDGF KLRLSGWYGN NKATRFNMAK
360 370 380 390 400
DFDPTPGAQG WVVSNPSGID LASLGAALSV YNLTTPADLR KKSLWLTAYA
410 420 430 440 450
EHLLNGILKD EAASSAGDGK KPAFRIITPS NKNERGAQLS VLLREGLLDV
460 470 480 490
VGEKMEAAGV VCDRRKPDVM RVAPVPMYNS YEDVWRCVDA LRKAVMS
Length:497
Mass (Da):54,479
Last modified:January 25, 2012 - v2
Checksum:iF15D53786575CFDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA Translation: EHA48171.1
CM001235 Genomic DNA Translation: EHA48172.1
RefSeqiXP_003717755.1, XM_003717707.1
XP_003717756.1, XM_003717708.1

Genome annotation databases

EnsemblFungiiMGG_10969T0; MGG_10969T0; MGG_10969
MGG_10969T1; MGG_10969T1; MGG_10969
GeneIDi2677723
KEGGimgr:MGG_10969

Similar proteinsi

Entry informationi

Entry nameiKYNU_MAGO7
AccessioniPrimary (citable) accession number: A4UBV5
Secondary accession number(s): G4NBX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 25, 2012
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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