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A4U7B6

- PB2_I51A0

UniProt

A4U7B6 - PB2_I51A0

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Protein

Polymerase basic protein 2

Gene
PB2
Organism
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: InterPro

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
  2. cap snatching Source: UniProtKB-KW
  3. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  4. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase basic protein 2
Gene namesi
Name:PB2
OrganismiInfluenza A virus (strain A/USA:Albany/12/1951 H1N1)
Taxonomic identifieri425580 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000007556: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell mitochondrion Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host mitochondrion, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Polymerase basic protein 2PRO_0000373035Add
BLAST

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.

Structurei

3D structure databases

ProteinModelPortaliA4U7B6.
SMRiA4U7B6. Positions 319-483, 685-759.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi736 – 7394Nuclear localization signal By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamiPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomiPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A4U7B6-1 [UniParc]FASTAAdd to Basket

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MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPSLRMKWM    50
MAMKYPITAD KRITEMIPER NEQGQTLWSK MNDAGSDRVM VSPLAVTWWN 100
RNGPMTSTVH YPKIYKTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG 150
HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLTITKEKK EELQDCKISP 200
LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQMYTPGGEV 250
RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GTRMVDILRQ 300
NPTEEQAVDI CKAAMGLRIS SSFSFGGFTF KRTSGSSVKR EEEVLTGNLQ 350
TLKIRVHEGY EEFTMVGKRA TAILRKATRR LIQLIVSGRD EQSIAEAIIV 400
AMVFSQEDCM IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKVLFQNWG 450
IEHIDNVMGM IGILPDMTPS TEMSMRGVRV SKMGVDEYSS AERVVVSIDR 500
FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN GPESVLVNTY 550
QWIIRNWETV KIQWSQNPTM LYNKMEFEPF QSLVPKAIRG QYSGFVRTLF 600
QQMRDVLGTF DTTQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILVR 650
GNSPVFNYNK TTKRLTVLGK DAGTLTEDPD EGTAGVESAV LRGFLILGKE 700
DRRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 750
TKRIRMAIN 759
Length:759
Mass (Da):86,071
Last modified:May 15, 2007 - v1
Checksum:i63FA70D0F3F3FD84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY021828 Viral cRNA. Translation: ABP49491.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY021828 Viral cRNA. Translation: ABP49491.1 .

3D structure databases

ProteinModelPortali A4U7B6.
SMRi A4U7B6. Positions 319-483, 685-759.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view ]
Pfami PF00604. Flu_PB2. 1 hit.
[Graphical view ]
ProDomi PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. The NIAID Influenza Genome Sequencing Consortium
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPB2_I51A0
AccessioniPrimary (citable) accession number: A4U7B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 15, 2007
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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