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A4U7A8

- M1_I51A0

UniProt

A4U7A8 - M1_I51A0

Protein

Matrix protein 1

Gene

M

Organism
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place By similarity.By similarity
    Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW
    2. structural constituent of virion Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host complement activation Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host complement factors by virus, Viral immunoevasion

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix protein 1
    Short name:
    M1
    Gene namesi
    Name:M
    OrganismiInfluenza A virus (strain A/USA:Albany/12/1951 H1N1)
    Taxonomic identifieri425580 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000007556: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus, Membrane, Viral matrix protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Matrix protein 1PRO_0000372907Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA4U7A8.
    SMRiA4U7A8. Positions 1-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 164164Membrane-bindingBy similarityAdd
    BLAST
    Regioni165 – 25288RNP-bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi101 – 1055Nuclear localization signalBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.10.180. 1 hit.
    1.20.91.10. 1 hit.
    InterProiIPR013188. Flu_matrix_M1_C.
    IPR001561. Flu_matrix_M1_N.
    IPR015423. Flu_matrix_M1_N_sub1.
    IPR015799. Flu_matrix_M1_N_sub2.
    [Graphical view]
    PfamiPF00598. Flu_M1. 1 hit.
    PF08289. Flu_M1_C. 1 hit.
    [Graphical view]
    ProDomiPD596253. Flu_matrix_M1_C. 1 hit.
    PD001061. Flu_matrix_M1_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00759. Flu_M1_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48145. SSF48145. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Only the first 9 residues are shared by the 2 isoforms.

    Isoform M1 (identifier: A4U7A8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MSLLTEVETY VLSIVPSGPL KAEIAQRLED VFAGKNTDLE ALMEWLKTRP    50
    ILSPLTKGIL GFVFTLTVPS ERGLQRRRFV QNALNGNGDP NNMDRAVKLY 100
    RKLKREITFH GAKEIALSYS AGALASCMGL IYNRMGAVTT EVAFGLVCAT 150
    CEQIADSQHR SHRQMVTTTN PLIRHENRMV LASTTAKAME QMAGSSEQAA 200
    EAMEVASQAR QMVQAMRAIG THPSSSAGLK DDLLENLQAY QKRMGVQMQR 250
    FK 252
    Length:252
    Mass (Da):27,834
    Last modified:May 15, 2007 - v1
    Checksum:i7317397B87CFD977
    GO
    Isoform M2 (identifier: A4U7A7-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry A4U7A7.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:97
    Mass (Da):11,178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY021822 Viral cRNA. Translation: ABP49482.1.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CY021822 Viral cRNA. Translation: ABP49482.1 .

    3D structure databases

    ProteinModelPortali A4U7A8.
    SMRi A4U7A8. Positions 1-158.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.10.180. 1 hit.
    1.20.91.10. 1 hit.
    InterProi IPR013188. Flu_matrix_M1_C.
    IPR001561. Flu_matrix_M1_N.
    IPR015423. Flu_matrix_M1_N_sub1.
    IPR015799. Flu_matrix_M1_N_sub2.
    [Graphical view ]
    Pfami PF00598. Flu_M1. 1 hit.
    PF08289. Flu_M1_C. 1 hit.
    [Graphical view ]
    ProDomi PD596253. Flu_matrix_M1_C. 1 hit.
    PD001061. Flu_matrix_M1_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00759. Flu_M1_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48145. SSF48145. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. The NIAID Influenza Genome Sequencing Consortium
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiM1_I51A0
    AccessioniPrimary (citable) accession number: A4U7A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3