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A4U6W1 (PB1F2_I45A0) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PB1-F2
Gene names
Name:PB1-F2
OrganismInfluenza A virus (strain A/USA:Huston/AA/1945 H1N1) [Complete proteome]
Taxonomic identifier425551 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis By similarity.

Subunit structure

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 By similarity.

Subcellular location

Host mitochondrion inner membrane. Host nucleus. Host cytoplasmhost cytosol. Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol By similarity.

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Sequence similarities

Belongs to the influenza viruses PB1-F2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9090Protein PB1-F2
PRO_0000373017

Regions

Region65 – 8723Mitochondrial targeting sequence By similarity

Sites

Site661Important for pathogenicity, S is highly pathogenic whereas N is low pathogenic By similarity

Sequences

Sequence LengthMass (Da)Tools
A4U6W1 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 0EB01ABBC390B4E2

FASTA9010,720
        10         20         30         40         50         60 
MGQEQDIPWI LSTGHISTQK GENGQQTPKL EHHNSTRLMG HCQKTMNRVV MPKQIVYWKQ 

        70         80         90 
WLSLRNPTLV FLKTHALKRW RLFSKHEWTS 

« Hide

References

[1]"The NIAID influenza genome sequencing project."
Ghedin E., Spiro D., Miller N., Zaborsky J., Feldblyum T., Subbu V., Shumway M., Sparenborg J., Groveman L., Halpin R., Sitz J., Koo H., Salzberg S.L., Webster R.G., Hoffmann E., Krauss S., Naeve C., Bao Y. expand/collapse author list , Bolotov P., Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]The NIAID Influenza Genome Sequencing Consortium
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CY021715 Viral cRNA. Translation: ABP49336.1.

3D structure databases

ProteinModelPortalA4U6W1.
SMRA4U6W1. Positions 50-87.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR021045. Flu_proapoptotic_PB1-F2.
[Graphical view]
PfamPF11986. PB1-F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePB1F2_I45A0
AccessionPrimary (citable) accession number: A4U6W1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families