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A4TS14

- PUR9_YERPP

UniProt

A4TS14 - PUR9_YERPP

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, YPDSF_3726
Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciYPES386656:GKD7-3818-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:YPDSF_3726
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000236: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018993Add
BLAST

Proteomic databases

PRIDEiA4TS14.

Interactioni

Protein-protein interaction databases

STRINGi386656.YPDSF_3726.

Structurei

3D structure databases

ProteinModelPortaliA4TS14.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TS14-1 [UniParc]FASTAAdd to Basket

« Hide

MQQRRPIRRA LLSVSDKAGI IEFAQALSQR GIELLSTGGT ARLLADAGLP    50
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGQDDGIM AQHGIQPIDI 100
VVVNLYPFAQ TVARPDCSLE DAVENIDIGG PTMVRSAAKN HKDVAIVVKS 150
SDYPAIITEL DNNDGSLTYP TRFNLAIKAF EHTAAYDSMI ANYFGTLVPP 200
YHGDTEQPSG HFPRTLNLNY IKKQDMRYGE NSHQQAAFYI EEDVKEASVA 250
TAQQLQGKAL SYNNIADTDA ALECVKEFSE PACVIVKHAN PCGVAIGDSI 300
LAAYERAYQT DPTSAFGGII AFNRELDAAT ASAIISRQFV EVIIAPTVSS 350
DALALLAAKQ NVRVLTCGQW QARSAGLDFK RVNGGLLVQE RDLGMVTAAD 400
LRVVSKRQPT EQELRDALFC WKVAKFVKSN AIVYARDNMT IGIGAGQMSR 450
VYSAKIAGIK AADEGLEVAG SAMASDAFFP FRDGIDAAAA VGITCVIQPG 500
GSIRDDEVIA AADEHSIAMI FTDMRHFRH 529
Length:529
Mass (Da):57,154
Last modified:May 15, 2007 - v1
Checksum:i5A76A59B82F39BFE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP42076.1.
RefSeqiYP_001165049.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP42076; ABP42076; YPDSF_3726.
GeneIDi5063065.
KEGGiypp:YPDSF_3726.
PATRICi18617549. VBIYerPes122972_4626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP42076.1 .
RefSeqi YP_001165049.1. NC_009381.1.

3D structure databases

ProteinModelPortali A4TS14.
ModBasei Search...

Protein-protein interaction databases

STRINGi 386656.YPDSF_3726.

Proteomic databases

PRIDEi A4TS14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP42076 ; ABP42076 ; YPDSF_3726 .
GeneIDi 5063065.
KEGGi ypp:YPDSF_3726.
PATRICi 18617549. VBIYerPes122972_4626.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci YPES386656:GKD7-3818-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides F.

Entry informationi

Entry nameiPUR9_YERPP
AccessioniPrimary (citable) accession number: A4TS14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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