A4TPA5 (HTPG_YERPP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HtpG

Alternative name(s):
Heat shock protein HtpG
High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	YPDSF_2755

Organism

Yersinia pestis (strain Pestoides F) [Complete proteome] [HAMAP]

Taxonomic identifier

386656 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	624 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity. HAMAP-Rule MF_00505
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the heat shock protein 90 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 624	624	Chaperone protein HtpG HAMAP-Rule MF_00505		PRO_1000014966
Regions
	Region	1 – 336	336	A; substrate-binding By similarity
	Region	337 – 552	216	B By similarity
	Region	553 – 624	72	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4TPA5 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 6E357E8B9C0F16F7	FASTA	624	71,031
	10 20 30 40 50 60 MNMKGQETRG FQSEVKQLLH LMIHSLYSNK EIFLRELISN ASDAADKLRF RALSNPELFE 70 80 90 100 110 120 GDGELRVRLS FDKEKRTLTL SDNGIGMTRD EVIDNLGTIA KSGTKAFLES IGSDQAKDSQ 130 140 150 160 170 180 LIGQFGVGFY SAFIVADKVT VRTRAAGAPA DTGVFWESAG EGDYTIADIT KDERGTEITL 190 200 210 220 230 240 HLREGEDEYL DDWRLRSVIS KYSDHIALPV EIQVKNEEDG TVTWEKINKA QALWTRGKAE 250 260 270 280 290 300 ISDDEYKAFY KHIAHDFTDP LSWSHNRVEG KQEYTSLLYI PAQAPWDMWN RDHKHGLKLY 310 320 330 340 350 360 VQRVFIMDEA EQFMPNYLRF VRGLIDSNDL PLNVSREILQ DSRITQNLRS ALTKRVLQML 370 380 390 400 410 420 EKLAKDDAEK YQQFWQQFGM ALKEGPAEDG SNKETIAKLL RFASTHTDSS AQTVSLEDYV 430 440 450 460 470 480 SRMAEGQEKI YYITADSYAA AKSSPHLELF RKKGIEVLLL SDRIDEWMMS YLTEFEGKAF 490 500 510 520 530 540 QSVSKADDSL NKLADEENPE QQEAEKALEP FVERVKTLLG ERVKDVRLTH RLTDTPAIVT 550 560 570 580 590 600 TDADEMSTQM AKLFAAAGQQ APEVKYIFEL NPDHGLVKRA AEVTDDTQFA QWVELLLDQA 610 620 LLAERGTLED PNQFIRRMNQ LLTA

References

[1]

"Complete sequence of chromosome of Yersinia pestis Pestoides F." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Di Bartolo G., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F. , Land M., Hauser L., Worsham P., Chu M., Bearden S., Garcia E., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pestoides F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000668 Genomic DNA. Translation: ABP41117.1.
RefSeq	YP_001164090.1. NC_009381.1.
3D structure databases
ProteinModelPortal	A4TPA5.
SMR	A4TPA5. Positions 3-624.
ModBase	Search...
Protein-protein interaction databases
STRING	386656.YPDSF_2755.
Proteomic databases
PRIDE	A4TPA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABP41117; ABP41117; YPDSF_2755.
GeneID	5063229.
KEGG	ypp:YPDSF_2755.
PATRIC	18615235. VBIYerPes122972_3501.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0326.
HOGENOM	HOG000031989.
KO	K04079.
OMA	LTDSPAC.
ProtClustDB	PRK05218.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
HAMAP	MF_00505. HSP90.
InterPro	IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit.
Pfam	PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPG_YERPP

Accession

Primary (citable) accession number: A4TPA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program