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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Probable phosphoglycerate mutase GpmB (gpmB), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Active sitei89Proton donor/acceptorUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Sitei184Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:YPDSF_2564
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000641181 – 2502,3-bisphosphoglycerate-dependent phosphoglycerate mutaseAdd BLAST250

Proteomic databases

PRIDEiA4TNS2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4TNS2.
SMRiA4TNS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingUniRule annotation8
Regioni23 – 24Substrate bindingUniRule annotation2
Regioni89 – 92Substrate bindingUniRule annotation4
Regioni116 – 117Substrate bindingUniRule annotation2
Regioni185 – 186Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221682.
KOiK01834.
OMAiRMLPYWY.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiView protein in InterPro
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiView protein in Pfam
PF00300. His_Phos_1. 1 hit.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TNS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKLVLVR HGESQWNNEN RFTGWYDVDL SEKGRSEAKA AGKLLKDEGF
60 70 80 90 100
TFDFAYTSVL KRAIHTLWNI LDELDQAWLP TEKTWKLNER HYGALQGLNK
110 120 130 140 150
SETAEKYGDE QVKQWRRGFA ITPPALEKSD ERFPGHDPRY AKLTDAELPT
160 170 180 190 200
TESLALTIER VIPYWNDVIK PRIASGERVI IAAHGNSLRA LVKYLDDLGE
210 220 230 240 250
DEILELNIPT GVPLVYEFDE NFKPIKHYYL GNADEIAAKA AAVANQGKAK
Length:250
Mass (Da):28,358
Last modified:May 15, 2007 - v1
Checksum:i3AF66E98C0AA8FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP40934.1.
RefSeqiWP_002210746.1. NZ_CP009715.1.

Genome annotation databases

EnsemblBacteriaiABP40934; ABP40934; YPDSF_2564.
KEGGiypp:YPDSF_2564.
PATRICifig|386656.14.peg.4084.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPMA_YERPP
AccessioniPrimary (citable) accession number: A4TNS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 15, 2007
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families