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A4TNP2 (BETA_YERPP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:YPDSF_2532
OrganismYersinia pestis (strain Pestoides F) [Complete proteome] [HAMAP]
Taxonomic identifier386656 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000046575

Regions

Nucleotide binding4 – 3330FAD By similarity

Sites

Active site4731 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4TNP2 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: F287B99E18166266

FASTA56762,492
        10         20         30         40         50         60 
MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA LAFPLQGKRY 

        70         80         90        100        110        120 
NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDFDHWASL SGLEDWSYLD 

       130        140        150        160        170        180 
CLPYFRKAET RDIGPNDFHG GEGPVSVTTP KIGNNPLFHA MVAAGVQAGY PRTDDLNGYQ 

       190        200        210        220        230        240 
QEGFGPMDRT VTPKGRRAST ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVRYLKG 

       250        260        270        280        290        300 
DAGTGQTAYA RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL 

       310        320        330        340        350        360 
EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR SRDAFTWPNI 

       370        380        390        400        410        420 
QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK SKDPRQHPSI LFNYMSSEQD 

       430        440        450        460        470        480 
WHEFRDAIRI TREIIAQPAL DPYRGREISP GANVQNDDEL DAFIREHAET AYHPSCSCKM 

       490        500        510        520        530        540 
GDDKMAVVDG QGRVHGVQGL RVVDASIMSQ IITGNLNATT IMIAEKIADR IRGCQPLAKS 

       550        560 
NAAYFIAGDT PARTSPVRHS LPVTSYP 

« Hide

References

[1]"Complete sequence of chromosome of Yersinia pestis Pestoides F."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Di Bartolo G., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Worsham P., Chu M., Bearden S., Garcia E., Richardson P.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pestoides F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000668 Genomic DNA. Translation: ABP40904.1.
RefSeqYP_001163877.1. NC_009381.1.

3D structure databases

ProteinModelPortalA4TNP2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING386656.YPDSF_2532.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP40904; ABP40904; YPDSF_2532.
GeneID5063464.
KEGGypp:YPDSF_2532.
PATRIC18614682. VBIYerPes122972_3236.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycYPES386656:GKD7-2579-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_YERPP
AccessionPrimary (citable) accession number: A4TNP2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways