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Protein

Cysteine synthase

Gene

cysM

Organism
Yersinia pestis (strain Pestoides F)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. cysteine synthase activity Source: UniProtKB-EC
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. cysteine biosynthetic process from serine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciYPES386656:GKD7-2160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine synthaseUniRule annotation (EC:2.5.1.47UniRule annotation)
Gene namesi
Name:cysMImported
Ordered Locus Names:YPDSF_2118Imported
ORF Names:BZ18_3435Imported
OrganismiYersinia pestis (strain Pestoides F)Imported
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000236 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi386656.YPDSF_2118.

Structurei

3D structure databases

ProteinModelPortaliA4TMI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0031.
HOGENOMiHOG000217394.
KOiK12339.
OMAiDITECIG.
OrthoDBiEOG6Q2SP8.

Family and domain databases

InterProiIPR005856. Cys_synthKM.
IPR005858. CysM.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01136. cysKM. 1 hit.
TIGR01138. cysM. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TMI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLEHCIGH TPLVKLQRLS QGLNAEIWVK LEGNNPAGSV KDRAALAMIQ
60 70 80 90 100
QAELRGDIAP GDVLIEATSG NTGIALAMIA AMKGYHLKLL MPENMSQERQ
110 120 130 140 150
AAMRAYGAEL ILVSREQGME GARDLALTMQ ENGEGNVLDQ FNNADNPYAH
160 170 180 190 200
FTGTGPEIWQ QTAGKVSHFV SSMGTTGTIT GVSQYLKSQN PQVKVIGLQP
210 220 230 240 250
AEGSSIPGIR RWSAEYIPGI FRPELVDQVL DITQSVAEQT MRRLAKEEGI
260 270 280 290
FCGVSSGGAV AGALRIAADN PDAVIVAIIC DRGDRYLSTG VF
Length:292
Mass (Da):31,279
Last modified:May 14, 2007 - v1
Checksum:i569CDEA6B4BE6721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP40497.1.
CP009715 Genomic DNA. Translation: AJI97768.1.
RefSeqiYP_001163470.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP40497; ABP40497; YPDSF_2118.
KEGGiypp:YPDSF_2118.
PATRICi18613690. VBIYerPes122972_2741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP40497.1.
CP009715 Genomic DNA. Translation: AJI97768.1.
RefSeqiYP_001163470.1. NC_009381.1.

3D structure databases

ProteinModelPortaliA4TMI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386656.YPDSF_2118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP40497; ABP40497; YPDSF_2118.
KEGGiypp:YPDSF_2118.
PATRICi18613690. VBIYerPes122972_2741.

Phylogenomic databases

eggNOGiCOG0031.
HOGENOMiHOG000217394.
KOiK12339.
OMAiDITECIG.
OrthoDBiEOG6Q2SP8.

Enzyme and pathway databases

BioCyciYPES386656:GKD7-2160-MONOMER.

Family and domain databases

InterProiIPR005856. Cys_synthKM.
IPR005858. CysM.
IPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01136. cysKM. 1 hit.
TIGR01138. cysM. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides FImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Pestoides FImported.

Entry informationi

Entry nameiA4TMI5_YERPP
AccessioniPrimary (citable) accession number: A4TMI5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 14, 2007
Last sequence update: May 14, 2007
Last modified: March 31, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.