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A4TM82

- FADJ_YERPP

UniProt

A4TM82 - FADJ_YERPP

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Protein

Fatty acid oxidation complex subunit alpha

Gene

fadJ

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei152 – 1521Important for catalytic activityUniRule annotation
Sitei174 – 1741Important for catalytic activityUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-HAMAP
  2. 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB-HAMAP
  3. enoyl-CoA hydratase activity Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid degradation, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciYPES386656:GKD7-2049-MONOMER.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alphaUniRule annotation
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimeraseUniRule annotation (EC:4.2.1.17UniRule annotation, EC:5.1.2.3UniRule annotation)
3-hydroxyacyl-CoA dehydrogenaseUniRule annotation (EC:1.1.1.35UniRule annotation)
Gene namesi
Name:fadJUniRule annotation
Ordered Locus Names:YPDSF_2013
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000236: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 774774Fatty acid oxidation complex subunit alphaPRO_0000323533Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi386656.YPDSF_2013.

Structurei

3D structure databases

ProteinModelPortaliA4TM82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224Enoyl-CoA hydrataseUniRule annotationAdd
BLAST
Regioni340 – 7744353-hydroxyacyl-CoA dehydrogenaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000261346.
KOiK01782.
OMAiPFRYMDT.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01617. FadJ.
InterProiIPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR02440. FadJ. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TM82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKENIVTRE NTAVSENAVS EPTVNNDVGA SATNSVTHPA FTLNVRPDNI
60 70 80 90 100
GIITIDVVGD KVNTLKAEFA DQIATILQQA HALPKLQGLV IVSGKPDSFI
110 120 130 140 150
AGADITMIAA CRTAHDARVL AQKGQSILAQ IAAFPVPVVA AIHGACLGGG
160 170 180 190 200
LELALACHSR ICSLDDKTVL GLPEVQLGLL PGSGGTQRLP RLVGVSKALD
210 220 230 240 250
MILTGKQIRP RQALKMGLVD DVVPRDILLD VAIQRAKAGW LNRRALPWQE
260 270 280 290 300
RLLSGPLGKA LLFRIVRKKT LAKTRGHYPA AERIIDVVRK GLDQGGPSGY
310 320 330 340 350
EAEARAFGEL AMSPQSAALR SLFFATTSLK KETGSAATAR AIHRVGVLGG
360 370 380 390 400
GLMGGGIANV TATRAGLPVR IKDINPQGIN QALKYTWDAL GKRVRSKRMR
410 420 430 440 450
PTEQQRQMML ISGSTDYRGF ERVDIVVEAV FEDLSLKQQM VADIERFGAA
460 470 480 490 500
HTIFASNTSS LPISQIAALA QRPEQVIGLH YFSPVDKMPL VEVIPHEKTS
510 520 530 540 550
EETIATTVAL ARKQGKTAIV VADRAGFYVN RILAPYINEA ARCLLDGEPI
560 570 580 590 600
ESVDNALVDF GFPVGPMMLL DEVGIDVATK IMPILVEQLG PRFAAPPSFD
610 620 630 640 650
VILKDGRKGR KNGRGFYLYS NPTKNSSPTK NGNSPAKRNS FKWRKNKVKP
660 670 680 690 700
VDASIYTLLG VTPKAHLGAG VITQRCTMLM LNEAVRCLDE SIIRNPRDGD
710 720 730 740 750
IGAVFGIGFP PFLGGPFRYL DSLGADKVVQ ALRLLVQQYG ERFEPCQRLV
760 770
TMAEQQQQFY PVDANIDEVT DVAS
Length:774
Mass (Da):83,594
Last modified:May 15, 2007 - v1
Checksum:iD10D346111BFD403
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40394.1.
RefSeqiYP_001163367.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP40394; ABP40394; YPDSF_2013.
GeneIDi5065641.
KEGGiypp:YPDSF_2013.
PATRICi18613436. VBIYerPes122972_2620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40394.1 .
RefSeqi YP_001163367.1. NC_009381.1.

3D structure databases

ProteinModelPortali A4TM82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386656.YPDSF_2013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP40394 ; ABP40394 ; YPDSF_2013 .
GeneIDi 5065641.
KEGGi ypp:YPDSF_2013.
PATRICi 18613436. VBIYerPes122972_2620.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000261346.
KOi K01782.
OMAi PFRYMDT.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

UniPathwayi UPA00659 .
BioCyci YPES386656:GKD7-2049-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPi MF_01617. FadJ.
InterProi IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR02440. FadJ. 1 hit.
PROSITEi PS00067. 3HCDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides F.

Entry informationi

Entry nameiFADJ_YERPP
AccessioniPrimary (citable) accession number: A4TM82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3