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A4TLP0

- PEPT_YERPP

UniProt

A4TLP0 - PEPT_YERPP

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Protein

Peptidase T

Gene

pepT

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1UniRule annotation
Active sitei80 – 801UniRule annotation
Metal bindingi140 – 1401Zinc 1UniRule annotation
Metal bindingi140 – 1401Zinc 2UniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation
Metal bindingi174 – 1741Zinc 2UniRule annotation
Metal bindingi196 – 1961Zinc 1UniRule annotation
Metal bindingi379 – 3791Zinc 2UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPES386656:GKD7-1853-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:YPDSF_1817
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000236: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Peptidase TPRO_1000017857Add
BLAST

Proteomic databases

PRIDEiA4TLP0.

Interactioni

Protein-protein interaction databases

STRINGi386656.YPDSF_1817.

Structurei

3D structure databases

ProteinModelPortaliA4TLP0.
SMRiA4TLP0. Positions 1-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiDCYIEVT.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TLP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKLLDRFFN YVSFDTQAKA NVKSVPSTQG QRKLAQALQQ ELLTLGFSHV
60 70 80 90 100
TLSDHGCVMA TLPANVSWPV PTIGFIAHLD TSPDFSGKNV NPQIVENYRG
110 120 130 140 150
GDIALGIGDE VLSPVMFPVL HQLLGHTLIT TDGKTLLGAD DKAGIAEIIT
160 170 180 190 200
AMVRLKHRNV PHGDIRIAFT PDEEVGKGAQ FFNVAEFDAQ WAYTVDGGGI
210 220 230 240 250
GELEFENFNA ASVAIKIVGN NVHPGSAKGV MVNALSLATR YHQELPVDET
260 270 280 290 300
PECTEGYDGF YHLQSIKGTV ERAEMHYIVR DFNRDSFEAR KKNMVDIAKR
310 320 330 340 350
VGKGLHRDCY IEIVIDDSYY NMREQIIKHP HIIELAQQAM LDCDITPIMK
360 370 380 390 400
PIRGGTDGAQ LSFKGLPCPN IFTGGYNYHG KHEFITLEGM EKAVAVIMRI
410
SELTAKRAKE S
Length:411
Mass (Da):45,387
Last modified:May 15, 2007 - v1
Checksum:i2D6E4D50923FC555
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1.
RefSeqiYP_001163175.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP40202; ABP40202; YPDSF_1817.
GeneIDi5064268.
KEGGiypp:YPDSF_1817.
PATRICi18612966. VBIYerPes122972_2385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1 .
RefSeqi YP_001163175.1. NC_009381.1.

3D structure databases

ProteinModelPortali A4TLP0.
SMRi A4TLP0. Positions 1-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386656.YPDSF_1817.

Protein family/group databases

MEROPSi M20.003.

Proteomic databases

PRIDEi A4TLP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP40202 ; ABP40202 ; YPDSF_1817 .
GeneIDi 5064268.
KEGGi ypp:YPDSF_1817.
PATRICi 18612966. VBIYerPes122972_2385.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
KOi K01258.
OMAi DCYIEVT.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci YPES386656:GKD7-1853-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides F.

Entry informationi

Entry nameiPEPT_YERPP
AccessioniPrimary (citable) accession number: A4TLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3