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A4TLP0

- PEPT_YERPP

UniProt

A4TLP0 - PEPT_YERPP

Protein

Peptidase T

Gene

pepT

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi140 – 1401Zinc 1UniRule annotation
    Metal bindingi140 – 1401Zinc 2UniRule annotation
    Active sitei173 – 1731Proton acceptorUniRule annotation
    Metal bindingi174 – 1741Zinc 2UniRule annotation
    Metal bindingi196 – 1961Zinc 1UniRule annotation
    Metal bindingi379 – 3791Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPES386656:GKD7-1853-MONOMER.

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:YPDSF_1817
    OrganismiYersinia pestis (strain Pestoides F)
    Taxonomic identifieri386656 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000236: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Peptidase TPRO_1000017857Add
    BLAST

    Proteomic databases

    PRIDEiA4TLP0.

    Interactioni

    Protein-protein interaction databases

    STRINGi386656.YPDSF_1817.

    Structurei

    3D structure databases

    ProteinModelPortaliA4TLP0.
    SMRiA4TLP0. Positions 1-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiDCYIEVT.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4TLP0-1 [UniParc]FASTAAdd to Basket

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    MDKLLDRFFN YVSFDTQAKA NVKSVPSTQG QRKLAQALQQ ELLTLGFSHV    50
    TLSDHGCVMA TLPANVSWPV PTIGFIAHLD TSPDFSGKNV NPQIVENYRG 100
    GDIALGIGDE VLSPVMFPVL HQLLGHTLIT TDGKTLLGAD DKAGIAEIIT 150
    AMVRLKHRNV PHGDIRIAFT PDEEVGKGAQ FFNVAEFDAQ WAYTVDGGGI 200
    GELEFENFNA ASVAIKIVGN NVHPGSAKGV MVNALSLATR YHQELPVDET 250
    PECTEGYDGF YHLQSIKGTV ERAEMHYIVR DFNRDSFEAR KKNMVDIAKR 300
    VGKGLHRDCY IEIVIDDSYY NMREQIIKHP HIIELAQQAM LDCDITPIMK 350
    PIRGGTDGAQ LSFKGLPCPN IFTGGYNYHG KHEFITLEGM EKAVAVIMRI 400
    SELTAKRAKE S 411
    Length:411
    Mass (Da):45,387
    Last modified:May 15, 2007 - v1
    Checksum:i2D6E4D50923FC555
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000668 Genomic DNA. Translation: ABP40202.1.
    RefSeqiYP_001163175.1. NC_009381.1.

    Genome annotation databases

    EnsemblBacteriaiABP40202; ABP40202; YPDSF_1817.
    GeneIDi5064268.
    KEGGiypp:YPDSF_1817.
    PATRICi18612966. VBIYerPes122972_2385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000668 Genomic DNA. Translation: ABP40202.1 .
    RefSeqi YP_001163175.1. NC_009381.1.

    3D structure databases

    ProteinModelPortali A4TLP0.
    SMRi A4TLP0. Positions 1-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386656.YPDSF_1817.

    Protein family/group databases

    MEROPSi M20.003.

    Proteomic databases

    PRIDEi A4TLP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP40202 ; ABP40202 ; YPDSF_1817 .
    GeneIDi 5064268.
    KEGGi ypp:YPDSF_1817.
    PATRICi 18612966. VBIYerPes122972_2385.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi DCYIEVT.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci YPES386656:GKD7-1853-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pestoides F.

    Entry informationi

    Entry nameiPEPT_YERPP
    AccessioniPrimary (citable) accession number: A4TLP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3