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Protein

Peptidase T

Gene

pepT

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1UniRule annotation
Active sitei80 – 801UniRule annotation
Metal bindingi140 – 1401Zinc 1UniRule annotation
Metal bindingi140 – 1401Zinc 2UniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation
Metal bindingi174 – 1741Zinc 2UniRule annotation
Metal bindingi196 – 1961Zinc 1UniRule annotation
Metal bindingi379 – 3791Zinc 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPES386656:GKD7-1853-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:YPDSF_1817
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Peptidase TPRO_1000017857Add
BLAST

Proteomic databases

PRIDEiA4TLP0.

Structurei

3D structure databases

ProteinModelPortaliA4TLP0.
SMRiA4TLP0. Positions 1-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TLP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLLDRFFN YVSFDTQAKA NVKSVPSTQG QRKLAQALQQ ELLTLGFSHV
60 70 80 90 100
TLSDHGCVMA TLPANVSWPV PTIGFIAHLD TSPDFSGKNV NPQIVENYRG
110 120 130 140 150
GDIALGIGDE VLSPVMFPVL HQLLGHTLIT TDGKTLLGAD DKAGIAEIIT
160 170 180 190 200
AMVRLKHRNV PHGDIRIAFT PDEEVGKGAQ FFNVAEFDAQ WAYTVDGGGI
210 220 230 240 250
GELEFENFNA ASVAIKIVGN NVHPGSAKGV MVNALSLATR YHQELPVDET
260 270 280 290 300
PECTEGYDGF YHLQSIKGTV ERAEMHYIVR DFNRDSFEAR KKNMVDIAKR
310 320 330 340 350
VGKGLHRDCY IEIVIDDSYY NMREQIIKHP HIIELAQQAM LDCDITPIMK
360 370 380 390 400
PIRGGTDGAQ LSFKGLPCPN IFTGGYNYHG KHEFITLEGM EKAVAVIMRI
410
SELTAKRAKE S
Length:411
Mass (Da):45,387
Last modified:May 15, 2007 - v1
Checksum:i2D6E4D50923FC555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1.
RefSeqiWP_002210920.1. NC_009381.1.
YP_001163175.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP40202; ABP40202; YPDSF_1817.
KEGGiypp:YPDSF_1817.
PATRICi18612966. VBIYerPes122972_2385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1.
RefSeqiWP_002210920.1. NC_009381.1.
YP_001163175.1. NC_009381.1.

3D structure databases

ProteinModelPortaliA4TLP0.
SMRiA4TLP0. Positions 1-408.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM20.003.

Proteomic databases

PRIDEiA4TLP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP40202; ABP40202; YPDSF_1817.
KEGGiypp:YPDSF_1817.
PATRICi18612966. VBIYerPes122972_2385.

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVYATIP.
OrthoDBiEOG6SV59Q.

Enzyme and pathway databases

BioCyciYPES386656:GKD7-1853-MONOMER.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides F.

Entry informationi

Entry nameiPEPT_YERPP
AccessioniPrimary (citable) accession number: A4TLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: June 24, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.