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A4TLP0

- PEPT_YERPP

UniProt

A4TLP0 - PEPT_YERPP

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Protein
Peptidase T
Gene
pepT, YPDSF_1817
Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides By similarity.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1 By similarity
Active sitei80 – 801 By similarity
Metal bindingi140 – 1401Zinc 1 By similarity
Metal bindingi140 – 1401Zinc 2 By similarity
Active sitei173 – 1731Proton acceptor By similarity
Metal bindingi174 – 1741Zinc 2 By similarity
Metal bindingi196 – 1961Zinc 1 By similarity
Metal bindingi379 – 3791Zinc 2 By similarity

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPES386656:GKD7-1853-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase T (EC:3.4.11.4)
Alternative name(s):
Aminotripeptidase
Short name:
Tripeptidase
Tripeptide aminopeptidase
Gene namesi
Name:pepT
Ordered Locus Names:YPDSF_1817
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000236: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Peptidase TUniRule annotation
PRO_1000017857Add
BLAST

Proteomic databases

PRIDEiA4TLP0.

Interactioni

Protein-protein interaction databases

STRINGi386656.YPDSF_1817.

Structurei

3D structure databases

ProteinModelPortaliA4TLP0.
SMRiA4TLP0. Positions 1-408.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiDCYIEVT.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TLP0-1 [UniParc]FASTAAdd to Basket

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MDKLLDRFFN YVSFDTQAKA NVKSVPSTQG QRKLAQALQQ ELLTLGFSHV    50
TLSDHGCVMA TLPANVSWPV PTIGFIAHLD TSPDFSGKNV NPQIVENYRG 100
GDIALGIGDE VLSPVMFPVL HQLLGHTLIT TDGKTLLGAD DKAGIAEIIT 150
AMVRLKHRNV PHGDIRIAFT PDEEVGKGAQ FFNVAEFDAQ WAYTVDGGGI 200
GELEFENFNA ASVAIKIVGN NVHPGSAKGV MVNALSLATR YHQELPVDET 250
PECTEGYDGF YHLQSIKGTV ERAEMHYIVR DFNRDSFEAR KKNMVDIAKR 300
VGKGLHRDCY IEIVIDDSYY NMREQIIKHP HIIELAQQAM LDCDITPIMK 350
PIRGGTDGAQ LSFKGLPCPN IFTGGYNYHG KHEFITLEGM EKAVAVIMRI 400
SELTAKRAKE S 411
Length:411
Mass (Da):45,387
Last modified:May 15, 2007 - v1
Checksum:i2D6E4D50923FC555
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1.
RefSeqiYP_001163175.1. NC_009381.1.

Genome annotation databases

EnsemblBacteriaiABP40202; ABP40202; YPDSF_1817.
GeneIDi5064268.
KEGGiypp:YPDSF_1817.
PATRICi18612966. VBIYerPes122972_2385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000668 Genomic DNA. Translation: ABP40202.1 .
RefSeqi YP_001163175.1. NC_009381.1.

3D structure databases

ProteinModelPortali A4TLP0.
SMRi A4TLP0. Positions 1-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386656.YPDSF_1817.

Protein family/group databases

MEROPSi M20.003.

Proteomic databases

PRIDEi A4TLP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABP40202 ; ABP40202 ; YPDSF_1817 .
GeneIDi 5064268.
KEGGi ypp:YPDSF_1817.
PATRICi 18612966. VBIYerPes122972_2385.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
KOi K01258.
OMAi DCYIEVT.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci YPES386656:GKD7-1853-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pestoides F.

Entry informationi

Entry nameiPEPT_YERPP
AccessioniPrimary (citable) accession number: A4TLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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