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A4TIP9

- MDTK_YERPP

UniProt

A4TIP9 - MDTK_YERPP

Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciYPES386656:GKD7-770-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance protein MdtKUniRule annotation
    Alternative name(s):
    Multidrug-efflux transporterUniRule annotation
    Gene namesi
    Name:mdtKUniRule annotation
    Ordered Locus Names:YPDSF_0755
    OrganismiYersinia pestis (strain Pestoides F)
    Taxonomic identifieri386656 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000236: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000049616Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi386656.YPDSF_0755.

    Structurei

    3D structure databases

    ProteinModelPortaliA4TIP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei188 – 20821HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei283 – 30119HelicalUniRule annotationAdd
    BLAST
    Transmembranei316 – 33621HelicalUniRule annotationAdd
    BLAST
    Transmembranei357 – 37721HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000038538.
    KOiK03327.
    OMAiGGVGCGW.
    OrthoDBiEOG6423C5.

    Family and domain databases

    HAMAPiMF_00400. MdtK.
    InterProiIPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4TIP9-1 [UniParc]FASTAAdd to Basket

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    MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG    50
    TSIWLPAILF GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV 100
    LIMLVLYNSD HVIKQMDNID PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ 150
    CEGLSKTKPG MVIGFVGLLV NIPINYIFIY GKFGAPALGG VGCGVATASV 200
    YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG LGLPVALALF 250
    FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG 300
    FRLGQGAVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV 350
    VTMASHLMLL AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL 400
    PSGYLLGLTD YILPAMGPAG FWIGFIIGLT AAAILMVLRI RWLQKQPTAF 450
    ILQRAAH 457
    Length:457
    Mass (Da):49,401
    Last modified:May 15, 2007 - v1
    Checksum:iAF81A08BC3B47987
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000668 Genomic DNA. Translation: ABP39161.1.
    RefSeqiYP_001162134.1. NC_009381.1.

    Genome annotation databases

    EnsemblBacteriaiABP39161; ABP39161; YPDSF_0755.
    GeneIDi5061783.
    KEGGiypp:YPDSF_0755.
    PATRICi18610461. VBIYerPes122972_1150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000668 Genomic DNA. Translation: ABP39161.1 .
    RefSeqi YP_001162134.1. NC_009381.1.

    3D structure databases

    ProteinModelPortali A4TIP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386656.YPDSF_0755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP39161 ; ABP39161 ; YPDSF_0755 .
    GeneIDi 5061783.
    KEGGi ypp:YPDSF_0755.
    PATRICi 18610461. VBIYerPes122972_1150.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000038538.
    KOi K03327.
    OMAi GGVGCGW.
    OrthoDBi EOG6423C5.

    Enzyme and pathway databases

    BioCyci YPES386656:GKD7-770-MONOMER.

    Family and domain databases

    HAMAPi MF_00400. MdtK.
    InterProi IPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pestoides F.

    Entry informationi

    Entry nameiMDTK_YERPP
    AccessioniPrimary (citable) accession number: A4TIP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3