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Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Yersinia pestis (strain Pestoides F)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtKUniRule annotation
Alternative name(s):
Multidrug-efflux transporterUniRule annotation
Gene namesi
Name:mdtKUniRule annotation
Ordered Locus Names:YPDSF_0755
OrganismiYersinia pestis (strain Pestoides F)
Taxonomic identifieri386656 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalUniRule annotationAdd BLAST21
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei188 – 208HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21
Transmembranei283 – 301HelicalUniRule annotationAdd BLAST19
Transmembranei316 – 336HelicalUniRule annotationAdd BLAST21
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21
Transmembranei387 – 407HelicalUniRule annotationAdd BLAST21
Transmembranei418 – 438HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000496161 – 457Multidrug resistance protein MdtKAdd BLAST457

Structurei

3D structure databases

ProteinModelPortaliA4TIP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.

Family and domain databases

HAMAPiMF_00400. MdtK. 1 hit.
InterProiIPR002528. MATE_fam.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TIP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG
60 70 80 90 100
TSIWLPAILF GHGLLLALTP TVAQLNGSGR RSQIAHQVRQ GFWLALCVSV
110 120 130 140 150
LIMLVLYNSD HVIKQMDNID PVLAQKAVGF LHAIMWGVPG YLFFQVLRNQ
160 170 180 190 200
CEGLSKTKPG MVIGFVGLLV NIPINYIFIY GKFGAPALGG VGCGVATASV
210 220 230 240 250
YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLSG LGLPVALALF
260 270 280 290 300
FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG
310 320 330 340 350
FRLGQGAVEQ AQVAAYTSMA VGLLLASVTA VFTIVFREHI ALLYNKTPEV
360 370 380 390 400
VTMASHLMLL AALYQLSDAV QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL
410 420 430 440 450
PSGYLLGLTD YILPAMGPAG FWIGFIIGLT AAAILMVLRI RWLQKQPTAF

ILQRAAH
Length:457
Mass (Da):49,401
Last modified:May 15, 2007 - v1
Checksum:iAF81A08BC3B47987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP39161.1.
RefSeqiWP_002210937.1. NZ_CP009715.1.

Genome annotation databases

EnsemblBacteriaiABP39161; ABP39161; YPDSF_0755.
KEGGiypp:YPDSF_0755.
PATRICi18610461. VBIYerPes122972_1150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000668 Genomic DNA. Translation: ABP39161.1.
RefSeqiWP_002210937.1. NZ_CP009715.1.

3D structure databases

ProteinModelPortaliA4TIP9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP39161; ABP39161; YPDSF_0755.
KEGGiypp:YPDSF_0755.
PATRICi18610461. VBIYerPes122972_1150.

Phylogenomic databases

HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.

Family and domain databases

HAMAPiMF_00400. MdtK. 1 hit.
InterProiIPR002528. MATE_fam.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
PIRSFiPIRSF006603. DinF. 1 hit.
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDTK_YERPP
AccessioniPrimary (citable) accession number: A4TIP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.