A4TEL0 (GLMM_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Mflv_4947

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000087770
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	240	1	Magnesium By similarity
	Metal binding	242	1	Magnesium By similarity
	Metal binding	244	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4TEL0 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: DF196783C60F7D98	FASTA	445	46,267
	10 20 30 40 50 60 MARLFGTDGV RGVANRELTP ELAMALGSAA ARRLGRAGAT RRRVAVVGRD PRASGEMLEA 70 80 90 100 110 120 AVIAGIAGEG VDTLRVGILP TPAVAYLTSA YDADFGVMIS ASHNPMPDNG IKIFGPGGHK 130 140 150 160 170 180 LDDATEDRIE ELVHQGPGER PTGAGIGRVV DAEDALERYL RHVGKAATTR LDPLTVVVDC 190 200 210 220 230 240 AHGAASVAAP RAYRAAGANV IPIHADPDGL NINDGCGSTH MESLRSAVVS YGADLGLAHD 250 260 270 280 290 300 GDADRCLAVD AHGRVIDGDA IMVVLALAMQ QSGELVSDTL VATVMSNMGL HLAMRSADIE 310 320 330 340 350 360 VRTTGVGDRY VLEELRAGQF SLGGEQSGHI VLPSFGTTGD GIVTGLRLMA RMAQTGRSLA 370 380 390 400 410 420 DLAQPMQTLP QVLINVEVAD KTTVADAPSV RDAVAQVEAE LGDTGRILLR PSGTEQVVRV 430 440 MVEAADEDTA RQMAVRVADS VSAES

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP47413.1.
RefSeq	YP_001136201.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4TEL0.
ModBase	Search...
Protein-protein interaction databases
STRING	A4TEL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000023718; EBMYCP00000023380; EBMYCG00000023713.
GeneID	4976258.
GenomeReviews	Gene locus Mflv_4947 in contig CP000656_GR.
KEGG	mgi:Mflv_4947.
PATRIC	18038152. VBIMycGil17082_5042.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
GeneTree	EBGT00050000015909.
HOGENOM	HBG644964.
OMA	GVGSTHL.
PhylomeDB	A4TEL0.
ProtClustDB	PRK14318.
Enzyme and pathway databases
BioCyc	MGIL350054:MFLV_4947-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_MYCGI

Accession

Primary (citable) accession number: A4TEL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program