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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mflv_4222
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986901 – 2142-phospho-L-lactate guanylyltransferaseAdd BLAST214

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_4222.

Structurei

3D structure databases

SMRiA4TE28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TE28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNSAPDADI GLVIAVKRLT AAKTRLAPVL SATNRESVVL AMLVDTIGAA
60 70 80 90 100
ITVPAVRSVL VVTPDDGAAS AARRLGARVL ADPTPAGHRD PLNNALSAAE
110 120 130 140 150
TAIREECSNI VVLQGDLPAL KSIELAEALH AARAHPRSFV TDRHGTGTAA
160 170 180 190 200
LFAFGVALQP RFGAGSAQRH RESGAVELTG DWPGLRSDID TPEDLVAACE
210
LGVGPATSQA ISAA
Length:214
Mass (Da):21,973
Last modified:May 15, 2007 - v1
Checksum:iE63FEC758DFC329A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP46691.1.
RefSeqiWP_011895066.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP46691; ABP46691; Mflv_4222.
KEGGimgi:Mflv_4222.

Similar proteinsi

Entry informationi

Entry nameiCOFC_MYCGI
AccessioniPrimary (citable) accession number: A4TE28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 15, 2007
Last modified: December 20, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families