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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81Charge relay systemUniRule annotation1
Active sitei156Charge relay systemUniRule annotation1
Active sitei180Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-ADT subunit AUniRule annotation
Gene namesi
Name:gatAUniRule annotation
Ordered Locus Names:Mflv_4246
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000761351 – 494Glutamyl-tRNA(Gln) amidotransferase subunit AAdd BLAST494

Proteomic databases

PRIDEiA4TE06

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi350054.Mflv_4246

Structurei

3D structure databases

ProteinModelPortaliA4TE06
SMRiA4TE06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3P Bacteria
COG0154 LUCA
HOGENOMiHOG000116699
KOiK02433
OMAiPITQNVE
OrthoDBiPOG091H00O9

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
HAMAPiMF_00120 GatA, 1 hit
InterProiView protein in InterPro
IPR000120 Amidase
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf
IPR004412 GatA
PANTHERiPTHR11895 PTHR11895, 1 hit
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
TIGRFAMsiTIGR00132 gatA, 1 hit
PROSITEiView protein in PROSITE
PS00571 AMIDASES, 1 hit

Sequencei

Sequence statusi: Complete.

A4TE06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELIKLDAA TLADKISSKE VSSAEVTQAF LDQIAATDGD YHAFLHVGAE
60 70 80 90 100
QALAAAQTVD RAVAAGEHLP SPLAGVPLAL KDVFTTTDMP TTCGSKVLEG
110 120 130 140 150
WTSPYDATVT AKLRSAGIPI LGKTNMDEFA MGSSTENSAY GPTRNPWDTE
160 170 180 190 200
RVPGGSGGGS AAALAAFQAP LAIGTDTGGS IRQPAALTAT VGVKPTYGTV
210 220 230 240 250
SRYGLVACAS SLDQGGPCAR TVLDTALLHQ VIAGHDPLDS TSVEAPVPDV
260 270 280 290 300
VAAARTGAGG DLTGVRIGVV KQLRSGEGYQ AGVLASFNAA VDQLTALGAE
310 320 330 340 350
VTEVDCPHFD YSLPAYYLIL PSEVSSNLAK FDGMRYGLRA GDDGTHSAEE
360 370 380 390 400
VMALTRAAGF GPEVKRRIMI GAYALSAGYY DAYYNQAQKV RTLIARDLDA
410 420 430 440 450
AYQKVDVLVS PATPTTAFRL GEKVDDPLSM YLFDLCTLPL NLAGHCGMSV
460 470 480 490
PSGLSADDNL PVGLQIMAPA LADDRLYRVG AAYEAARGPL PTAL
Length:494
Mass (Da):51,222
Last modified:May 15, 2007 - v1
Checksum:iD3A44A7C7791CB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP46715.1
RefSeqiWP_011895090.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP46715; ABP46715; Mflv_4246
KEGGimgi:Mflv_4246

Similar proteinsi

Entry informationi

Entry nameiGATA_MYCGI
AccessioniPrimary (citable) accession number: A4TE06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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