ID   A4TDH5_MYCGI            Unreviewed;      1361 AA.
AC   A4TDH5;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=Mflv_4423 {ECO:0000313|EMBL:ABP46892.1};
OS   Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS   PYR-GCK)).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350054 {ECO:0000313|EMBL:ABP46892.1};
RN   [1] {ECO:0000313|EMBL:ABP46892.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PYR-GCK {ECO:0000313|EMBL:ABP46892.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABP46892.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-GCK {ECO:0000313|EMBL:ABP46892.1};
RX   PubMed=23469141;
RA   Badejo A.C., Badejo A.O., Shin K.H., Chai Y.G.;
RT   "A Gene Expression Study of the Activities of Aromatic Ring-Cleavage
RT   Dioxygenases in Mycobacterium gilvum PYR-GCK to Changes in Salinity and pH
RT   during Pyrene Degradation.";
RL   PLoS ONE 8:E58066-E58066(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; CP000656; ABP46892.1; -; Genomic_DNA.
DR   STRING; 350054.Mflv_4423; -.
DR   KEGG; mgi:Mflv_4423; -.
DR   eggNOG; COG0745; Bacteria.
DR   eggNOG; COG2172; Bacteria.
DR   eggNOG; COG2205; Bacteria.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_000445_82_3_11; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 2.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR   PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 2.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Kinase {ECO:0000313|EMBL:ABP46892.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW   ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:ABP46892.1}.
FT   DOMAIN          328..544
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   DOMAIN          605..721
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          737..767
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   MOD_RES         654
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   1361 AA;  147938 MW;  62B0CF646B077716 CRC64;
     MNWAQTPLGP TSEWPQSLQT AANILLSSRF PMWMAWGPDL TFFCNDAYRN VTLGRKYPWA
     LGRPASEVWA EIWDDIGPRI ERVLSTGVAT WDTSLLLFLE RSGYTEESYH TFSYSPLRDD
     DGAVVGMLCV VSEDTLQVIG ERRMATLRDL GSDPSVVRTE GEILSFVDRQ LAQNLRDLPF
     TLTYLFDDDG SAHLAGMSGI TGDHPAAPDV LTGADGELWP VGPPAGGETV LLEVDTAPYP
     AMPTGDWREP PRQVLIVPLL QQGAAPTGFL VAGLNRYRVL DDAYRGFVAL VAGHIAAGIG
     LSRSYRTQQM RAEELAELDR AKTTFFSNIS HEFRTPLTLI LDPVSELRRA DTLGDAARQE
     LDVVWRNGLR LNKLVNTLLD FSRIEAGRTQ AHYQPVDLGA VTAELASVFR SAIERAGLVF
     DVDCPPLGEE AYVDLDMWEK VIFNLLSNAL KFTFEGSVSV TARRDGRGAV ITVSDTGTGV
     PADEMPRLFE RFHRIENTRA RSNEGSGIGL ALVKELVGLH GGTIEADSAE SRGTTFTIRL
     PWGAGHLPAD AVASQPRERR PGNTVDAYVE EALRWTPDGV REYVAESAQP TTGPEKPIGT
     GTLARVLVAD DNADMREYLG RLLRSDGYAV EAVVDGWQAL EAIRAEPPDL VISDVMMPRL
     DGLGLVAELR ADRRTAAVPV LLLSARAGQE ASISGLQAGA DDYLVKPFAA AELLARVRAN
     IQLARLREGH ARWRTALVDS LQEAFFVCDE HGAVVEINPA FTEILGYDST GLPYPLMHPW
     WPLKGSDAEA NRRVEEAFGS FMRDPHGTLT EVPVTHRDGH RLYVTVTFSH ADDPETGRDV
     IVGTLRDVTA ERYIVQRESA LASLNEKLAQ ADTLDDAVLA AAEEFSSIWS ARRVVAATWP
     DEPDGEHESD APSLTVVGAP ATWDGLPGSA RELILTLRRD HLLAPHTSDA GAAGVALRHP
     RGVLVLYVEL PEQRLFTAED DTLLTVLAGR LGQGLQRVHQ IDQQRETALA LQHAILGPSL
     SSAFAVRYQP ATRPLQVGGD WYDVVDLEDG RIGLIVGDCV GHGLAAATVM GQLRSACRAL
     LLEHPSPAAA LSALDRFAAR LPGARCTTAF CAVLDPRIGE VVYSCAGHPP PIMVTADRTT
     ELLEGARATP LGLKNPPHRT EARVTMPARA TLLLYTDGLV ERRRESIDDG IARATDVVQG
     NRATDLDQLA NVIMARLAPA DGYHDDVALL LYRQPEPLDL DFPADVAELA GSRTVLRGWL
     DSAGVPQDQA LDVLIAVGEA LANAIEHGHR DDPGGRVRLR AVALPDRVQL TIIDTGSWKA
     PDDVPALHRG RGIALMKALM QDVTIDSQTT GTTVHMNTRI A
//