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Protein

Thymidylate synthase ThyX

Gene

thyX

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-4047-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase ThyXUniRule annotation (EC:2.1.1.148UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyXUniRule annotation
Ordered Locus Names:Mflv_4001
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Thymidylate synthase ThyXPRO_1000184592Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350054.Mflv_4001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 233227ThyXUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi95 – 10511ThyX motifAdd
BLAST

Sequence similaritiesi

Belongs to the thymidylate synthase ThyX family.UniRule annotation
Contains 1 thyX (flavin-dependent thymidylate synthase) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SMJ. Bacteria.
COG1351. LUCA.
HOGENOMiHOG000047391.
KOiK03465.
OMAiACYQSWN.
OrthoDBiEOG6SFP8J.

Family and domain databases

HAMAPiMF_01408. ThyX.
InterProiIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
PfamiPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMiSSF69796. SSF69796. 1 hit.
TIGRFAMsiTIGR02170. thyX. 1 hit.
PROSITEiPS51331. THYX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4TCJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIAPLRVQ LIAKTEFSAP PDVEWSTDAD GGAALVEFAG RACYQSWSKP
60 70 80 90 100
NPRTATNATY VRHIIDVGHF SVLEHASVSF YITGLSRSCT HELIRHRHFS
110 120 130 140 150
YSQLSQRYVP ENDAEVVAPP GIEDDPELLA LFTAATDASR AAYTELLNRL
160 170 180 190 200
EAKLADQGTS TLRRKQARQA ARAVLPNATE TRIVVTGNYR AWRHFIAMRA
210 220 230 240 250
SEHADVEIRR LAIECLRRLV AVAPQVFSDF EITALADGTE VATSPLATEV
Length:250
Mass (Da):27,604
Last modified:May 15, 2007 - v1
Checksum:iBE6306C7C8A16BFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP46472.1.
RefSeqiWP_011894852.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP46472; ABP46472; Mflv_4001.
KEGGimgi:Mflv_4001.
PATRICi18036205. VBIMycGil17082_4073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP46472.1.
RefSeqiWP_011894852.1. NC_009338.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350054.Mflv_4001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP46472; ABP46472; Mflv_4001.
KEGGimgi:Mflv_4001.
PATRICi18036205. VBIMycGil17082_4073.

Phylogenomic databases

eggNOGiENOG4107SMJ. Bacteria.
COG1351. LUCA.
HOGENOMiHOG000047391.
KOiK03465.
OMAiACYQSWN.
OrthoDBiEOG6SFP8J.

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-4047-MONOMER.

Family and domain databases

HAMAPiMF_01408. ThyX.
InterProiIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
PfamiPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMiSSF69796. SSF69796. 1 hit.
TIGRFAMsiTIGR02170. thyX. 1 hit.
PROSITEiPS51331. THYX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PYR-GCK.

Entry informationi

Entry nameiTHYX_MYCGI
AccessioniPrimary (citable) accession number: A4TCJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 15, 2007
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.