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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi527MagnesiumUniRule annotation1
Metal bindingi533MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mflv_4023
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000879931 – 756Polyribonucleotide nucleotidyltransferaseAdd BLAST756

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_4023

Structurei

3D structure databases

ProteinModelPortaliA4TCH6
SMRiA4TCH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini593 – 652KHUniRule annotationAdd BLAST60
Domaini664 – 733S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A4TCH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVEIEEGV FESTATIDNG SFGTRTIRFE TGRLARQAAG AVVAYLDDET
60 70 80 90 100
MLLSATTASK QPKEHFDFFP LTIDVEERMY AAGRIPGSFF RREGRPSTDA
110 120 130 140 150
ILTCRLIDRP LRPTFISGLR NEIQVVVTVL SLDPKDLYDV LAINAASAST
160 170 180 190 200
QISGIPFNGP VGGVRVALID GQWVAFPTVE QLEKAVFDMV VAGRKVGDAG
210 220 230 240 250
NEDVAIMMVE AEATDKVIEL VAGGAGAPTE AVVAEGLEAA KPFIAALCDA
260 270 280 290 300
QAALAGAAGK ETAEYPVFPD YAEDVYYSVA SVATDALSEA LTIAGKEARD
310 320 330 340 350
DRTNEIKAEV VERLAEQYAG REKEIGAAYR SLTKKLVRQR ILTDHFRIDG
360 370 380 390 400
RGVTDIRALS AEVAVIPRAH GSALFERGET QIMGVTTLDM VKMAQQIDSL
410 420 430 440 450
GPETSKRYMH HYNFPPYSTG ETGRVGSPKR REIGHGALAE RALMPVLPSV
460 470 480 490 500
EEFPYAIRQV SEALSSNGST SMGSVCASTL SLLNAGVPLK APVAGIAMGL
510 520 530 540 550
VSDDVEVEGG GVERRFVTLT DILGAEDAFG DMDFKCAGTK DFVTALQLDT
560 570 580 590 600
KLDGIPSQVL AGALAQAKDA RITILEVMAE AIDEPDEMSP YAPRITTIKV
610 620 630 640 650
PVDKIGEVIG PKGKMINSIT EETGASISIE DDGTVFVGAS NGEAAQAAID
660 670 680 690 700
KINAIANPQL PKVGERFLGT VVKTTDFGAF VSLLPGRDGL VHISKLGRGK
710 720 730 740 750
RINKVEDVAK VGDKLRVEIA DIDNRGKISL VLVAEEEAGA ATPEAPAPAD

AATSSS
Length:756
Mass (Da):80,174
Last modified:May 15, 2007 - v1
Checksum:i647CDA4F2E7D515D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP46493.1
RefSeqiWP_011894873.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP46493; ABP46493; Mflv_4023
KEGGimgi:Mflv_4023

Similar proteinsi

Entry informationi

Entry nameiPNP_MYCGI
AccessioniPrimary (citable) accession number: A4TCH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health