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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:Mflv_4052
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000780331 – 518Probable malate:quinone oxidoreductaseAdd BLAST518

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_4052.

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiPOG091H0B7C.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TCE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAEKTDVL LVGAGIMSAT LCALLRLLEP NWSMTLVERL DGAAAESSDP
60 70 80 90 100
WNNAGTGHSA LCELNYTPAR PDGSIDIAKA VNVNEQFQVS RQFWTYAVEN
110 120 130 140 150
GVLPDVRSFL NPIPHVSFVT GADNVQYLRK RYEALVGNPL FGTMEFIDDA
160 170 180 190 200
GEFARRLPLM AEGRDLREPV GLNWTQDGTD VDFGALSRQL LGFGAQQGMD
210 220 230 240 250
TLFGHDVTNL SQNSDSTWTV KVVNRRTGRK RTFNAKFVFV GAGGGALPLL
260 270 280 290 300
QKAGIKEAKG FGGFPVGGQW LRTGNPELTA KHQAKVYGLP PLGAPPMSVP
310 320 330 340 350
HLDTRVINDK SWLLFGPFAG WSPKFLKQGK VTDLPFSVKP DNLVSMLGVG
360 370 380 390 400
LTEMGLLKYL IGQLLLSEAA RVENLREFAP SAKDSDWELD IAGQRVQVIR
410 420 430 440 450
KAKGKGGVLE FGTTVLSAAD GSIAGLLGAS PGASTAVPAM FDVMKRCFAD
460 470 480 490 500
RYPSWEPKLK EMVPSLGVTL SDEPKLFEEV WARGTKVLKL DKPAGAIPAT
510
TDGQSTAGTE HTPTAATV
Length:518
Mass (Da):55,788
Last modified:May 15, 2007 - v1
Checksum:iBD59AFE2E14F142E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP46522.1.
RefSeqiWP_011894902.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP46522; ABP46522; Mflv_4052.
KEGGimgi:Mflv_4052.

Similar proteinsi

Entry informationi

Entry nameiMQO_MYCGI
AccessioniPrimary (citable) accession number: A4TCE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families