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A4TCB7 (A4TCB7_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Mflv_4083
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential EMBL ABP46553.1
Chain27 – 387361 Potential EMBL ABP46553.1
PRO_5000236308

Regions

Nucleotide binding10 – 3930NADP By similarity HAMAP MF_00183

Sites

Metal binding1431Divalent metal cation By similarity HAMAP MF_00183
Metal binding1451Divalent metal cation By similarity HAMAP MF_00183
Metal binding2141Divalent metal cation By similarity HAMAP MF_00183
Binding site1201Substrate By similarity HAMAP MF_00183
Binding site1451Substrate By similarity HAMAP MF_00183
Binding site1691Substrate By similarity HAMAP MF_00183
Binding site1921Substrate By similarity HAMAP MF_00183
Binding site2141Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A4TCB7 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 53736E7301682A18

FASTA38740,130
        10         20         30         40         50         60 
MNERLRVLIL GSTGSIGTQA LEVIAANPDR FEVVGLAAGG GNRDLLARQR AETGVTNIAV 

        70         80         90        100        110        120 
ADEAAAAALG EVTYSGPDAV TRLVEATEAD VVLNGLVGAL GLKPTLAALA TGARLALANK 

       130        140        150        160        170        180 
ESLVAGGPLV QKAAAPGQIV PVDSEHSALA QCLRGGSADE VATLVLTASG GPFRGWSVDR 

       190        200        210        220        230        240 
LEDVTPEQAG AHPTWSMGPM NTLNSASLVN KGLELIETHL LFGIDYDRID VVVHPQSIVH 

       250        260        270        280        290        300 
SMVTFTDGST LAQASPPDMK LPIALALGWP ARVAGAAAAC DFSTASRWDF EPLDDEVFPA 

       310        320        330        340        350        360 
VALAREAGKT GGCMTAIYNA ANEEAAEAFL AGRIRFPAIV RTVAEVLRAA DQWAAEPATV 

       370        380 
DDVLDAQNWA RDRARSAVER ESAGSRS

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP46553.1.
RefSeqYP_001135341.1. NC_009338.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4TCB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000023707; EBMYCP00000023369; EBMYCG00000023702.
GeneID4975397.
GenomeReviewsGene locus Mflv_4083 in contig CP000656_GR.
KEGGmgi:Mflv_4083.
PATRIC18036373. VBIMycGil17082_4157.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
GeneTreeEBGT00050000016490.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4TCB7_MYCGI
AccessionPrimary (citable) accession number: A4TCB7
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info