A4TBY0 (PYRB_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Mflv_3747

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000073733

Sequences

	Sequence		Length	Mass (Da)
	A4TBY0 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 784DBC8C9FDD7D2A	FASTA	315	33,793
	10 20 30 40 50 60 MKHLLTAADL SRDDATAILD NADRFREALV GREVKKLPTL RGRTIITMFY ENSTRTRVSF 70 80 90 100 110 120 EVAGKWMSAD VINVSASGSS VAKGESLRDT ALTLRAAGAD ALIIRHPASG APQQLAAWTL 130 140 150 160 170 180 DEHGGPSVIN AGDGTHEHPT QALLDALTIR QRLGSVEGKR VVIVGDVLHS RVARSNVALL 190 200 210 220 230 240 HTLGAEVVLV APPTLLPVGV TEWPVTVSHE LDAELPLADA VLMLRVQAER MNGGFFPSSR 250 260 270 280 290 300 EYSVRYGLSE KRQSTLADHA VVLHPGPMLR GMEIAYSVAD SSQSAVLQQV SNGVHVRMAV 310 LFHLLVGSEE EAISA

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP46219.1.
RefSeq	YP_001135007.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4TBY0.
ModBase	Search...
Protein-protein interaction databases
STRING	A4TBY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000023678; EBMYCP00000023340; EBMYCG00000023673.
GeneID	4975063.
GenomeReviews	Gene locus Mflv_3747 in contig CP000656_GR.
KEGG	mgi:Mflv_3747.
PATRIC	18035667. VBIMycGil17082_3808.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000016463.
HOGENOM	HBG579429.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	MGIL350054:MFLV_3747-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_MYCGI

Accession

Primary (citable) accession number: A4TBY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program