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A4TBX9 (A4TBX9_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:Mflv_3746
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
A4TBX9 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: A78E9E9217F10C8D

FASTA42745,048
        10         20         30         40         50         60 
MSVVLKSVRL YGEGDAVDVL VRDGIIAEIG TGLSADETID CTGRVLLPGF VDLHTHLREP 

        70         80         90        100        110        120 
GREYAEDIET GSAAAALGGY TAVFAMANTD PVADSVVVTD HVWQRGQQVG LVDVHPVGAV 

       130        140        150        160        170        180 
TVGLAGKQLT EMGLMAAGTG RVRMFSDDGV CVDDPLLMRR ALEYASGLGV LIAQHAEEPR 

       190        200        210        220        230        240 
LTVGAVAHEG PNAARLGLAG WPRAAEESIV ARDALLARDA GARVHICHAS TAGTVELVRW 

       250        260        270        280        290        300 
AKEQGIAITA EVTPHHLLLD DTRLETYDGR NRVNPPLREV SDTLALRQAL ADGVIDCVAT 

       310        320        330        340        350        360 
DHAPHGEHEK MCEFANARPG MLGLQTALSV VVETMVQPGP LTWRDVARVM SEAPARIVGL 

       370        380        390        400        410        420 
PDQGRPLEVG EPANLTVVDP DARWTVSGPA LASRSDNTPY EAMELPGVVT ATLLRGTVTA 


RDGKAGA

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP46218.1.
RefSeqYP_001135006.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4TBX9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4TBX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000027451; EBMYCP00000027113; EBMYCG00000027446.
GeneID4975062.
GenomeReviewsGene locus Mflv_3746 in contig CP000656_GR.
KEGGmgi:Mflv_3746.
PATRIC18035665. VBIMycGil17082_3807.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
GeneTreeEBGT00050000016208.
HOGENOMHBG724623.
OMACDVHPVG.
PhylomeDBA4TBX9.
ProtClustDBPRK09357.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4TBX9_MYCGI
AccessionPrimary (citable) accession number: A4TBX9
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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