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A4TBR8 (A4TBR8_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase HAMAP-Rule MF_00127
EC=6.1.1.21 HAMAP-Rule MF_00127
Alternative name(s):
Histidyl-tRNA synthetase HAMAP-Rule MF_00127
Gene names
Name:hisS HAMAP-Rule MF_00127
Ordered Locus Names:Mflv_3809 EMBL ABP46281.1
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP] EMBL ABP46281.1
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127 SAAS SAAS015807

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00127 RuleBase RU003746

Sequences

Sequence LengthMass (Da)Tools
A4TBR8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 4FFC58B96CFAD901

FASTA42045,186
        10         20         30         40         50         60 
MTDSFKAPKG VPDYFPPDSA EFVAVRSGLL TAARRAGYGD IELPIFEDTA LFARGVGEST 

        70         80         90        100        110        120 
DVVSKEMYTF ADRGERSVTL RPEGTAGVMR AVIEHGLDRG QLPVKLCYSG PFFRYERPQA 

       130        140        150        160        170        180 
GRYRQLQQVG IEAIGVDDPA LDAEVMAVAD AGFRSLGLDG FRLEITSLGD DSCRPQYREL 

       190        200        210        220        230        240 
LQEFLFKLDL DEETRQRAQL NPLRVLDDKR PHVREMTANA PVMLDHLSDA AKEHFDTVLA 

       250        260        270        280        290        300 
HLDALSVPYV INPRMVRGLD YYTKTTFEFV HDGLGAQSGI GGGGRYDGLM AQLGGRDLSG 

       310        320        330        340        350        360 
IGFGLGVDRT LLALRAEGKA AGETARVDVY AVPLGADAKV RLAVLAAQLR AAGVRVDVAY 

       370        380        390        400        410        420 
GDRSLKGAMK GADRSGASIA LVAGDRDLEA GTVGVKSMAT GEQVDVASDD VVAEVLSRLT

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK EMBL ABP46281.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP46281.1.
RefSeqYP_001135069.1. NC_009338.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING350054.Mflv_3809.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP46281; ABP46281; Mflv_3809.
GeneID4975125.
KEGGmgi:Mflv_3809.
PATRIC18035793. VBIMycGil17082_3871.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018072.
KOK01892.
OMACGGGNFK.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycMGIL350054:GHK8-4206-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4TBR8_MYCGI
AccessionPrimary (citable) accession number: A4TBR8
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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