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A4TBR2 (APT_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7
Gene names
Name:apt
Ordered Locus Names:Mflv_3813
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004

Subunit structure

Homodimer By similarity. HAMAP MF_00004

Subcellular location

Cytoplasm By similarity HAMAP MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processadenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Adenine phosphoribosyltransferase HAMAP MF_00004
PRO_0000329357

Sequences

Sequence LengthMass (Da)Tools
A4TBR2 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: 63A68C446AFC2BD8

FASTA17918,078
        10         20         30         40         50         60 
MSGEPGTDIA EVIRSLMREV PDFPEPGVHF KDLTPVLADA YGLAEVSRAI ADSARGADLV 

        70         80         90        100        110        120 
AGVDARGFLL GGAVAVTLGI GVLAVRKGGK LPPPVLGETY TLEYGSATLE VPADGVELAG 

       130        140        150        160        170 
RSVVVIDDVL ATGGTLAAAH QLLTKAGANV TGAVVMMELT ALGGRAAVDP LEVTSLYSV

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP46285.1.
RefSeqYP_001135073.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4TBR2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4TBR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000024638; EBMYCP00000024300; EBMYCG00000024633.
GeneID4975129.
GenomeReviewsGene locus Mflv_3813 in contig CP000656_GR.
KEGGmgi:Mflv_3813.
PATRIC18035801. VBIMycGil17082_3875.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
GeneTreeEBGT00050000016328.
HOGENOMHBG703830.
OMAGMEARGF.
ProtClustDBPRK02304.

Enzyme and pathway databases

BioCycMGIL350054:MFLV_3813-MONOMER.

Family and domain databases

HAMAPMF_00004. Aden_phosphoribosyltr.
[Tree]
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase.
[Graphical view]
KOK00759.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT_MYCGI
AccessionPrimary (citable) accession number: A4TBR2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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