A4TAE5 (A4TAE5_MYCGI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate dehydrogenase RuleBase RU000422
EC=1.1.1.37 RuleBase RU000422

Gene names

Ordered Locus Names:

Mflv_3339

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU000422 SAAS SAAS010945
Subunit structure	Homodimer By similarity. SAAS SAAS010945
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU000422 SAAS SAAS010945
Ligand	NAD RuleBase RU000422 SAAS SAAS010945
Molecular function	Oxidoreductase RuleBase RU000421 EMBL ABP45815.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A4TAE5 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 16BE6B017EBC9699	FASTA	331	34,635
	10 20 30 40 50 60 MSSATPPVTV AVTGAAGQIG YAALFRIAAG AMLGHDTPVT LRLLELPDAV RAAEGVVMEL 70 80 90 100 110 120 DDGAFPLLAG TEIYDDPTRA FDGVDVALLI GAKPRTKGME RADLLSANAQ IFATSGRALN 130 140 150 160 170 180 AGAGRDVRIL VVGNPANTNA LVAAAHAPDI PRDRFTALTR LDHNRAVAAM ARHSGVPVTE 190 200 210 220 230 240 ISRMIIWGNH SPTQYPDIFH SVVGGRAGAD YAADTRWLTD DFIPTVARRG TAIIEARGAS 250 260 270 280 290 300 SAASAANGAI DHVDDWMHGT PDGDWTSVAL PSPGVYGVDE GLVCSFPCRS VDGRWEIVDG 310 320 330 LDVNPFSRAR IDASVAELRA ERDAVAALGL L

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP45815.1.
RefSeq	YP_001134603.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4TAE5.
ModBase	Search...
Protein-protein interaction databases
STRING	A4TAE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000026238; EBMYCP00000025900; EBMYCG00000026233.
GeneID	4974659.
GenomeReviews	Gene locus Mflv_3339 in contig CP000656_GR.
KEGG	mgi:Mflv_3339.
PATRIC	18034822. VBIMycGil17082_3392.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0039.
GeneTree	EBGT00050000018111.
HOGENOM	HBG289884.
OMA	DPNVAFK.
ProtClustDB	PRK05442.
Family and domain databases
HAMAP	MF_01517. Malate_dehydrog_2. [Tree]
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00024.
PANTHER	PTHR23382. MDH_SF1. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01759. MalateDH-SF1. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A4TAE5_MYCGI

Accession

Primary (citable) accession number: A4TAE5

Entry history

Integrated into UniProtKB/TrEMBL:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)