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A4TAC8 (A4TAC8_MYCGI) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:Mflv_3359
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding16 – 216NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding39 – 413NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding81 – 833NADP By similarity PIRSR PIRSR000109-3
Region135 – 1373Substrate binding By similarity PIRSR PIRSR000109-2
Region192 – 1932Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1891Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1961Proton donor By similarity PIRSR PIRSR000109-1
Binding site1091NADP By similarity PIRSR PIRSR000109-3
Binding site1091Substrate By similarity PIRSR PIRSR000109-2
Binding site1971Substrate By similarity PIRSR PIRSR000109-2
Binding site2671Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2941Substrate By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4581Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A4TAC8 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: AB938EB6B1019B25

FASTA48451,984
        10         20         30         40         50         60 
MSSSGTTGSA QIGVTGLAVM GSNIARNFAR HGYTVALHNR SVAKTDALLA EHGSDGNFVR 

        70         80         90        100        110        120 
SETIAEFLDA LEKPRRVLIM VKAGDPTDAV INELADAMEE GDIIIDGGNA LYTDTIRREK 

       130        140        150        160        170        180 
AIRERGLHFV GAGISGGEEG ALNGPSIMPG GPAESYASLG PLLEEISAHV DGVPCCTHIG 

       190        200        210        220        230        240 
PDGAGHFVKM VHNGIEYSDM QLIGEAYQLL RDGLGKSAPE IADVFDEWNA GDLDSFLVEI 

       250        260        270        280        290        300 
TAQVLRQTDA TTGTPLVDVI LDEAEQKGTG RWTVKSALDL GVPVTGIAEA VFARALSGSV 

       310        320        330        340        350        360 
AQRKATTGLA SGDLGEKPGD AEQFVEDIRQ ALYASKIIAY AQGFNQIQAG SDEYDWDIKP 

       370        380        390        400        410        420 
GDMARIWRGG CIIRAKFLNR ITDAFDNDPG LPTLIVDPYF RDAIEAAIDS WRRVVVKATE 

       430        440        450        460        470        480 
LGIPIPGFSS ALSYYDGLRT ERLPAALTQG LRDFFGAHTY GRIDTDRERR FHTLWSGDRT 


EVEA

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References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP45835.1.
RefSeqYP_001134623.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4TAC8.
SMRA4TAC8. Positions 10-476.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4TAC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000025568; EBMYCP00000025230; EBMYCG00000025563.
GeneID4974679.
GenomeReviewsGene locus Mflv_3359 in contig CP000656_GR.
KEGGmgi:Mflv_3359.
PATRIC18034864. VBIMycGil17082_3413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA4TAC8.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4TAC8_MYCGI
AccessionPrimary (citable) accession number: A4TAC8
Entry history
Integrated into UniProtKB/TrEMBL: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info