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A4TA90

- GCSP_MYCGI

UniProt

A4TA90 - GCSP_MYCGI

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (15 May 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMGIL350054:GHK8-3434-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Mflv_3398
    OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
    Taxonomic identifieri350054 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000232: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_1000083209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi350054.Mflv_3398.

    Structurei

    3D structure databases

    ProteinModelPortaliA4TA90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4TA90-1 [UniParc]FASTAAdd to Basket

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    MPDQTPAPSV LRFVDRHIGP DDQAVETLLN TIGVPSLDEL AAKALPDVIL    50
    DRLSTDGVAP GLEHLPAAAT EHEALAELRA LAQSNTVAVS MIGQGYYDTL 100
    TPPVLRRNII ENPAWYTAYT PYQPEISQGR LEALLNFQTM VTDLTGLEVA 150
    NASMLDEGTA AAEAMTLMHR AVRGPATRLA VDADVYPQTA AILATRAEPL 200
    GIEIVTADLR QGLPDGDFFG VIVQLPGASG VVHDWSALVE QAHERGALVA 250
    VGADLLAATM ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLAVHSKHA 300
    RQLPGRLVGV SVDADGSRAY RLALQTREQH IRRDKATSNI CTAQVLLAVL 350
    AAMYASYHGP DGLRGIAQRV HGHARALAAG LADAGVEVVH DSFFDTVLAH 400
    VPGRADEVRA AAKERGINVW AVDADHVSVA CDEATTAEHV ADVLAAFGAA 450
    PSGADFAGPA VATRTSEFLT HPAFSDYRTE TSMMRYLRSL ADKDIALDRS 500
    MIPLGSCTMK LNAAAEMEAI TWAEFGRQHP FAPASDTPGL RRLIADLQSW 550
    LTGITGYDEI SLQPNAGSQG EYAGLLAIQA YHHARGDSGR TVCLIPSSAH 600
    GTNAASAAMV GMKVVVVACR ANGDVDLDDL RAKVTEHADR LSALMITYPS 650
    THGVYEHDIA DICAAVHDAG GQVYVDGANL NALVGLARPG RFGGDVSHLN 700
    LHKTFCIPHG GGGPGVGPVA VRAHLAPYLP GHPLAAELSD DHTVSAAPYG 750
    SASILPITWA YIRMMGAAGL RSATLVAIAS ANYIARRLDE YYPVLYTGEN 800
    GMVAHECILD LRGITKATGV TVDDVAKRLA DYGFHAPTMS FPVAGTLMVE 850
    PTESESLSEI DAFCDAMIAI RAEIDRVGSG EWPVDDNPLR GAPHTAESLL 900
    VEEWTHPYTR EQAAYPLGKG FRPKVWPPVR RIDGAYGDRN LVCSCPPVEA 950
    FA 952
    Length:952
    Mass (Da):100,876
    Last modified:May 15, 2007 - v1
    Checksum:iCBB4069F4EFB2A68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000656 Genomic DNA. Translation: ABP45874.1.
    RefSeqiYP_001134662.1. NC_009338.1.

    Genome annotation databases

    EnsemblBacteriaiABP45874; ABP45874; Mflv_3398.
    GeneIDi4974718.
    KEGGimgi:Mflv_3398.
    PATRICi18034942. VBIMycGil17082_3452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000656 Genomic DNA. Translation: ABP45874.1 .
    RefSeqi YP_001134662.1. NC_009338.1.

    3D structure databases

    ProteinModelPortali A4TA90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 350054.Mflv_3398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABP45874 ; ABP45874 ; Mflv_3398 .
    GeneIDi 4974718.
    KEGGi mgi:Mflv_3398.
    PATRICi 18034942. VBIMycGil17082_3452.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci MGIL350054:GHK8-3434-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PYR-GCK.

    Entry informationi

    Entry nameiGCSP_MYCGI
    AccessioniPrimary (citable) accession number: A4TA90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3