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A4TA90 (GCSP_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Mflv_3398
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length952 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 952952Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083209

Amino acid modifications

Modified residue7031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A4TA90 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: CBB4069F4EFB2A68

FASTA952100,876
        10         20         30         40         50         60 
MPDQTPAPSV LRFVDRHIGP DDQAVETLLN TIGVPSLDEL AAKALPDVIL DRLSTDGVAP 

        70         80         90        100        110        120 
GLEHLPAAAT EHEALAELRA LAQSNTVAVS MIGQGYYDTL TPPVLRRNII ENPAWYTAYT 

       130        140        150        160        170        180 
PYQPEISQGR LEALLNFQTM VTDLTGLEVA NASMLDEGTA AAEAMTLMHR AVRGPATRLA 

       190        200        210        220        230        240 
VDADVYPQTA AILATRAEPL GIEIVTADLR QGLPDGDFFG VIVQLPGASG VVHDWSALVE 

       250        260        270        280        290        300 
QAHERGALVA VGADLLAATM ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLAVHSKHA 

       310        320        330        340        350        360 
RQLPGRLVGV SVDADGSRAY RLALQTREQH IRRDKATSNI CTAQVLLAVL AAMYASYHGP 

       370        380        390        400        410        420 
DGLRGIAQRV HGHARALAAG LADAGVEVVH DSFFDTVLAH VPGRADEVRA AAKERGINVW 

       430        440        450        460        470        480 
AVDADHVSVA CDEATTAEHV ADVLAAFGAA PSGADFAGPA VATRTSEFLT HPAFSDYRTE 

       490        500        510        520        530        540 
TSMMRYLRSL ADKDIALDRS MIPLGSCTMK LNAAAEMEAI TWAEFGRQHP FAPASDTPGL 

       550        560        570        580        590        600 
RRLIADLQSW LTGITGYDEI SLQPNAGSQG EYAGLLAIQA YHHARGDSGR TVCLIPSSAH 

       610        620        630        640        650        660 
GTNAASAAMV GMKVVVVACR ANGDVDLDDL RAKVTEHADR LSALMITYPS THGVYEHDIA 

       670        680        690        700        710        720 
DICAAVHDAG GQVYVDGANL NALVGLARPG RFGGDVSHLN LHKTFCIPHG GGGPGVGPVA 

       730        740        750        760        770        780 
VRAHLAPYLP GHPLAAELSD DHTVSAAPYG SASILPITWA YIRMMGAAGL RSATLVAIAS 

       790        800        810        820        830        840 
ANYIARRLDE YYPVLYTGEN GMVAHECILD LRGITKATGV TVDDVAKRLA DYGFHAPTMS 

       850        860        870        880        890        900 
FPVAGTLMVE PTESESLSEI DAFCDAMIAI RAEIDRVGSG EWPVDDNPLR GAPHTAESLL 

       910        920        930        940        950 
VEEWTHPYTR EQAAYPLGKG FRPKVWPPVR RIDGAYGDRN LVCSCPPVEA FA 

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000656 Genomic DNA. Translation: ABP45874.1.
RefSeqYP_001134662.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4TA90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING350054.Mflv_3398.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABP45874; ABP45874; Mflv_3398.
GeneID4974718.
KEGGmgi:Mflv_3398.
PATRIC18034942. VBIMycGil17082_3452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycMGIL350054:GHK8-3434-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_MYCGI
AccessionPrimary (citable) accession number: A4TA90
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families