Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-3434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Mflv_3398
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000232: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 952952Glycine dehydrogenase (decarboxylating)PRO_1000083209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi350054.Mflv_3398.

Structurei

3D structure databases

ProteinModelPortaliA4TA90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A4TA90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDQTPAPSV LRFVDRHIGP DDQAVETLLN TIGVPSLDEL AAKALPDVIL
60 70 80 90 100
DRLSTDGVAP GLEHLPAAAT EHEALAELRA LAQSNTVAVS MIGQGYYDTL
110 120 130 140 150
TPPVLRRNII ENPAWYTAYT PYQPEISQGR LEALLNFQTM VTDLTGLEVA
160 170 180 190 200
NASMLDEGTA AAEAMTLMHR AVRGPATRLA VDADVYPQTA AILATRAEPL
210 220 230 240 250
GIEIVTADLR QGLPDGDFFG VIVQLPGASG VVHDWSALVE QAHERGALVA
260 270 280 290 300
VGADLLAATM ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLAVHSKHA
310 320 330 340 350
RQLPGRLVGV SVDADGSRAY RLALQTREQH IRRDKATSNI CTAQVLLAVL
360 370 380 390 400
AAMYASYHGP DGLRGIAQRV HGHARALAAG LADAGVEVVH DSFFDTVLAH
410 420 430 440 450
VPGRADEVRA AAKERGINVW AVDADHVSVA CDEATTAEHV ADVLAAFGAA
460 470 480 490 500
PSGADFAGPA VATRTSEFLT HPAFSDYRTE TSMMRYLRSL ADKDIALDRS
510 520 530 540 550
MIPLGSCTMK LNAAAEMEAI TWAEFGRQHP FAPASDTPGL RRLIADLQSW
560 570 580 590 600
LTGITGYDEI SLQPNAGSQG EYAGLLAIQA YHHARGDSGR TVCLIPSSAH
610 620 630 640 650
GTNAASAAMV GMKVVVVACR ANGDVDLDDL RAKVTEHADR LSALMITYPS
660 670 680 690 700
THGVYEHDIA DICAAVHDAG GQVYVDGANL NALVGLARPG RFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPVA VRAHLAPYLP GHPLAAELSD DHTVSAAPYG
760 770 780 790 800
SASILPITWA YIRMMGAAGL RSATLVAIAS ANYIARRLDE YYPVLYTGEN
810 820 830 840 850
GMVAHECILD LRGITKATGV TVDDVAKRLA DYGFHAPTMS FPVAGTLMVE
860 870 880 890 900
PTESESLSEI DAFCDAMIAI RAEIDRVGSG EWPVDDNPLR GAPHTAESLL
910 920 930 940 950
VEEWTHPYTR EQAAYPLGKG FRPKVWPPVR RIDGAYGDRN LVCSCPPVEA

FA
Length:952
Mass (Da):100,876
Last modified:May 15, 2007 - v1
Checksum:iCBB4069F4EFB2A68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP45874.1.
RefSeqiYP_001134662.1. NC_009338.1.

Genome annotation databases

EnsemblBacteriaiABP45874; ABP45874; Mflv_3398.
GeneIDi4974718.
KEGGimgi:Mflv_3398.
PATRICi18034942. VBIMycGil17082_3452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA. Translation: ABP45874.1.
RefSeqiYP_001134662.1. NC_009338.1.

3D structure databases

ProteinModelPortaliA4TA90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi350054.Mflv_3398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP45874; ABP45874; Mflv_3398.
GeneIDi4974718.
KEGGimgi:Mflv_3398.
PATRICi18034942. VBIMycGil17082_3452.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciMGIL350054:GHK8-3434-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PYR-GCK.

Entry informationi

Entry nameiGCSP_MYCGI
AccessioniPrimary (citable) accession number: A4TA90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.