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Protein

Catalase-peroxidase

Gene

katG

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei109Transition state stabilizerUniRule annotation1
Active sitei113Proton acceptorUniRule annotation1
Metal bindingi280Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-3521-MONOMER

Protein family/group databases

PeroxiBasei3622 MgiCP01_PYR-GCK

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Mflv_3451
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548371 – 748Catalase-peroxidaseAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112 ↔ 239Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-265)UniRule annotation
Cross-linki239 ↔ 265Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-112)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA4TA35

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi350054.Mflv_3451

Structurei

3D structure databases

ProteinModelPortaliA4TA35
SMRiA4TA35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 2 hits

Sequencei

Sequence statusi: Complete.

A4TA35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTSDARPP HSDAKTASNS ESENPAIDSP EPKSHAPLTN RDWWPEQVDV
60 70 80 90 100
SVLHKQNEKG NPFGEDFDYA AEFAKLDVDA FKADVIDLIR TSQDWWPADY
110 120 130 140 150
GNYAGLFVRM SWHAAGTYRI FDGRGGAGQG SQRFAPLNSW PDNANLDKAR
160 170 180 190 200
RLLWPIKQKY GNKISWADLI AYAGNAALEQ SGFKTAGFAF GREDIWEPEE
210 220 230 240 250
MLWGQEDTWL GTDKRYGGSN DDKRELAEPF GATTMGLIYV NPEGPEGKPD
260 270 280 290 300
PLAAAHDIRE TFGRMAMNDE ETAALIVGGH TLGKTHGAAD VNVGPEPEGA
310 320 330 340 350
PMEQQGLGWK CPFGTGNGND TVTSGLEVIW TGTNSQWSNA FLENLYGNEW
360 370 380 390 400
ELTKSPAGAW QFEAKNAEAT IPDPFGGPPR KPTMLVTDVA MREDPIYGQI
410 420 430 440 450
TRRWLDHPEE MDAAFAKAWF KLMHRDMGPV SRYLGPWVPA EQEIWQDPVP
460 470 480 490 500
AVDHALIDES DIAALKSQVL QSGLSVPQLV KTAWASAASF RGTDKRGGAN
510 520 530 540 550
GARLRLEPQR NWEANEPAEL DKVLPVLEKI QQDFNSTATG GKKVSLADVI
560 570 580 590 600
VLAGSAAVEK AAKDGGYEIT VHFAPGRTDA TQESTDVESF AVLEPRTDGF
610 620 630 640 650
RNFFRPGDKN PLEQQLVERA YLLDLTAPEL TALIGGLRAL GANHGGSKHG
660 670 680 690 700
VFTDKPGVLS NDFFLNLLDM RTEWKPSELS ENVFDGKDRA TGETKWTATA
710 720 730 740
NDLVFGSNSV LRALAEVYAQ DDNQGKFVED FVAAWVKVMN NDRFDLKQ
Length:748
Mass (Da):82,278
Last modified:May 15, 2007 - v1
Checksum:i4576A542A1AD523E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP45926.1
RefSeqiWP_011894310.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP45926; ABP45926; Mflv_3451
KEGGimgi:Mflv_3451

Entry informationi

Entry nameiKATG_MYCGI
AccessioniPrimary (citable) accession number: A4TA35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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