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A4T9W3 (ARLY_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mflv_3523
OrganismMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]
Taxonomic identifier350054 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000073850

Sequences

Sequence LengthMass (Da)Tools
A4T9W3 [UniParc].

Last modified May 15, 2007. Version 1.
Checksum: D0759E7D9E2D5809

FASTA47050,020
        10         20         30         40         50         60 
MSTNEGSLWG GRFADGPADA LAALSKSTHF DWVLAPYDVV ASKAHARVLF RAGLLTEEQR 

        70         80         90        100        110        120 
DGLLAGLDSL GSDVADGSFG PLVSDEDVHG ALERGLIDRV GPELGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRLWLRDAV RRVADGVLEV VGALTTQAAA HPTAIMPGKT HLQSAQPVLL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVDRLAD FDKRAAVSPY GSGALAGSSL GLDPDAIAEE LGFAAAADNS IDATASRDFA 

       250        260        270        280        290        300 
AEAAFVFSMI GVDLSRLAED VILWSTTEFG YVELHDAWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLTG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL VATLRFDVDR 

       370        380        390        400        410        420 
MAELAPLGYT LATDVAEWLV RRGVPFRVAH EAAGAAVRAA EARGVGLEEL EDAELAGIHP 

       430        440        450        460        470 
ELTAEVRDVL STEGSVNSRD ARGGTAPIQV ARQLGAVRDT ADELRRRLRR

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PYR-GCK.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000656 Genomic DNA. Translation: ABP45997.1.
RefSeqYP_001134785.1. NC_009338.1.

3D structure databases

ProteinModelPortalA4T9W3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4T9W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000025338; EBMYCP00000025000; EBMYCG00000025333.
GeneID4974841.
GenomeReviewsGene locus Mflv_3523 in contig CP000656_GR.
KEGGmgi:Mflv_3523.
PATRIC18035210. VBIMycGil17082_3582.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMGIL350054:MFLV_3523-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCGI
AccessionPrimary (citable) accession number: A4T9W3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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