A4T9N5 (TRPC_MYCGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Mflv_3600

Organism

Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) [Complete proteome] [HAMAP]

Taxonomic identifier

350054 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000076421

Sequences

	Sequence		Length	Mass (Da)
	A4T9N5 [UniParc]. Last modified May 15, 2007. Version 1. Checksum: 2B4DE9BF2407C571	FASTA	272	28,172
	10 20 30 40 50 60 MGSATVLDSI LEGVRADVAA REAVVSLAEV KARAERAPAP LDVMAALRAP GIAVIAEVKR 70 80 90 100 110 120 ASPSRGELAS IADPAELASA YESGGARAIS VLTEQRRFNG SLDDLDAVRA AVSIPVLRKD 130 140 150 160 170 180 FIVRPYQIHE ARAHGADLLL LIVAALEQPA LESLLERTES LGMTALVEVH TEEEADRALQ 190 200 210 220 230 240 AGASLIGVNA RNLKTLEVDR DCFARIAPGL PTNVIKIAES GVRGTADLLA YAGAGADGVL 250 260 270 VGEGLVTSGD PRSAVADLVT AGTHPSCPKP AR

References

[1]

"Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PYR-GCK.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000656 Genomic DNA. Translation: ABP46074.1.
RefSeq	YP_001134862.1. NC_009338.1.
3D structure databases
ProteinModelPortal	A4T9N5.
ModBase	Search...
Protein-protein interaction databases
STRING	A4T9N5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000026287; EBMYCP00000025949; EBMYCG00000026282.
GeneID	4974918.
GenomeReviews	Gene locus Mflv_3600 in contig CP000656_GR.
KEGG	mgi:Mflv_3600.
PATRIC	18035370. VBIMycGil17082_3660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	MRKDDVT.
PhylomeDB	A4T9N5.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MGIL350054:MFLV_3600-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCGI

Accession

Primary (citable) accession number: A4T9N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program