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Protein

8-amino-7-oxononanoate synthase

Gene

Mflv_3628

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.By similarity

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].

Cofactori

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei175Pyridoxal phosphateBy similarity1
Binding sitei345SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBiotin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-3704-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthase (EC:2.3.1.47)
Short name:
AONS
Alternative name(s):
7-keto-8-amino-pelargonic acid synthase
Short name:
7-KAP synthase
Short name:
KAPA synthase
8-amino-7-ketopelargonate synthase
Alpha-oxoamine synthase
Gene namesi
Ordered Locus Names:Mflv_3628
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex
Proteomesi
  • UP000000232 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003810351 – 3808-amino-7-oxononanoate synthaseAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiA4T9L3

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi350054.Mflv_3628

Structurei

3D structure databases

ProteinModelPortaliA4T9L3
SMRiA4T9L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Pyridoxal phosphate bindingBy similarity2
Regioni200 – 203Pyridoxal phosphate bindingBy similarity4
Regioni232 – 235Pyridoxal phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221021
KOiK00652
OMAiFGTIGEN
OrthoDBiPOG091H024U

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4T9L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRAGLSPLA WLDEVETQRR AAGLRRSLRA RPPVGTVLDL ASNDYLGLSQ
60 70 80 90 100
HPRVIDGGVA ALRTWGAGAT GSRLVTGNTE LHEQFEDALA SFVGADSALV
110 120 130 140 150
FSSGYTANLG AVVALSGPGS LLVSDAYTHA SLVDACRLSR ARVVVTPHND
160 170 180 190 200
VAAVARALAT RDEERAVVVT DSVFSADGDL APLRELHDAC RRHGALMIVD
210 220 230 240 250
EAHGLGVRGD RGRGLLDEVG LAGAPDVVMT TTLSKALGSQ GGVVLGPAAV
260 270 280 290 300
RDHLIDAARP FIFDTGLAPA AVGAAHAALQ VLVEEPWRAQ RVLDHATTLA
310 320 330 340 350
QICGVADVPS SAVVSVILGE PEVALAAAMG CLERGVRVGC FRPPTVPAGT
360 370 380
SRLRLTARAS LSDDEMALAR EVLTDVLSRA
Length:380
Mass (Da):39,420
Last modified:May 15, 2007 - v1
Checksum:iC4C081B31E7BEB25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP46102.1
RefSeqiWP_011894485.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP46102; ABP46102; Mflv_3628
KEGGimgi:Mflv_3628

Similar proteinsi

Entry informationi

Entry nameiBIOF_MYCGI
AccessioniPrimary (citable) accession number: A4T9L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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