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Protein

Pantothenate kinase

Gene

coaA

Organism
Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Mflv_3738)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Mflv_3738)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGIL350054:G1G8L-2093-MONOMER
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaAUniRule annotation
Ordered Locus Names:Mflv_2058
OrganismiMycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK))
Taxonomic identifieri350054 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000000232 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000780581 – 312Pantothenate kinaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi350054.Mflv_2058

Structurei

3D structure databases

ProteinModelPortaliA4T9A9
SMRiA4T9A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS9 Bacteria
COG1072 LUCA
HOGENOMiHOG000248571
KOiK00867
OMAiLMQRKGF
OrthoDBiPOG091H073G

Family and domain databases

CDDicd02025 PanK, 1 hit
HAMAPiMF_00215 Pantothen_kinase_1, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004566 PanK
IPR006083 PRK/URK
PANTHERiPTHR10285:SF7 PTHR10285:SF7, 1 hit
PfamiView protein in Pfam
PF00485 PRK, 1 hit
PIRSFiPIRSF000545 Pantothenate_kin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00554 panK_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A4T9A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLSEPSPY VEFDRAQWRA LRMSTPLKLT EDELVRLRGI GEKIDLLEVE
60 70 80 90 100
EVYLPLARLI HLQVAARQAL FATTADFLGE PQQNPDRPVP FVIGVAGSVA
110 120 130 140 150
VGKSTTARVL QALLARWEHH PRVDLVTTDG FLYSNSELSR RNLMHRKGFP
160 170 180 190 200
ESYDRRGLMR FVTTVKSGSD VACAPVYSHL LYDIVPGEKQ IIEHPDILIL
210 220 230 240 250
EGLNVLQTGP ALMVSDLFDF SVYVDARIED IENWYISRFL KMREGAFADP
260 270 280 290 300
ASHFHHYSTL TDEQAVFAAR DIWHSINRPN LIENILPTRP RATLVLRKDS
310
DHSINRLRLR KL
Length:312
Mass (Da):35,589
Last modified:May 15, 2007 - v1
Checksum:i96BB65FE24715A33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000656 Genomic DNA Translation: ABP44536.1
RefSeqiWP_011892947.1, NC_009338.1

Genome annotation databases

EnsemblBacteriaiABP44536; ABP44536; Mflv_2058
KEGGimgi:Mflv_2058

Similar proteinsi

Entry informationi

Entry nameiCOAA_MYCGI
AccessioniPrimary (citable) accession number: A4T9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 15, 2007
Last modified: June 20, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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